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公开(公告)号：US20240416008A1
公开(公告)日：2024-12-19
申请号：US18443314
申请日：2024-02-16
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Dino Di Carlo , Westbrook Weaver , Tatiana Segura , Jaekyung Koh , Philip Scumpia , Donald R. Griffin
Abstract: A hydrogel material for use in a human subject or other mammal includes a collection of microgel particles having one or more network cross linker components, wherein the microgel particles, when exposed to an endogenous or exogenous annealing agent, links the microgel particles together in situ to form a covalently-stabilized scaffold of microgel particles having pores formed between the microgel particles wherein the pores are substantially devoid of hydrogel.
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公开(公告)号：US20190142965A1
公开(公告)日：2019-05-16
申请号：US16092202
申请日：2017-04-10
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Tatiana Segura , Donald Griffin , Philip Scumpia
IPC: A61K47/69 , A61K47/60 , A61P17/02 , A61K39/39 , A61K38/06 , A61K38/48 , A61K39/00 , A61K39/02 , A61K39/12
Abstract: An immune-modulating biomaterial comprising a hydrogel scaffold coupled to D-amino acid containing peptides having unexpected properties in vivo is described. For example, certain inflammatory reactions in vivo are significantly increased around the D-peptide containing particles of hydrogel scaffold as compared to particles that contain both L and D peptides or L peptides alone. In addition, these D-peptide compositions are further observed to enhance wound healing and improve the tensile strength of healed tissues. For these and other reasons, the D-amino acid hydrogel materials disclosed herein are useful in a number of methodologies that seek to modulate the immune response and/or wound healing.
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公开(公告)号：US11464886B2
公开(公告)日：2022-10-11
申请号：US17144158
申请日：2021-01-08
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Donald R. Griffin , Westbrook Weaver , Tatiana Segura , Dino Di Carlo , Philip Scumpia
IPC: A61L26/00 , A61L27/18 , A61L27/58 , A61K47/62 , A61K9/06 , A61K31/795 , A61L27/22 , A61L27/52 , A61L27/54 , A61L27/56
Abstract: A microporous gel system for certain applications, including biomedical applications, includes an aqueous solution containing plurality of microgel particles including a biodegradable crosslinker. In some aspects, the microgel particles act as gel building blocks that anneal to one another to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. In certain aspects, annealing of the microgel particles occurs after exposure to an annealing agent that is endogenously present or exogenously added. In some embodiments, annealing of the microgel particles requires the presence of an initiator such as exposure to light. In particular embodiments, the chemical and physical properties of the gel building blocks can be controlled to allow downstream control of the resulting assembled scaffold. In one or more embodiments, cells are able to quickly infiltrate the interstitial spaces of the assembled scaffold.
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公开(公告)号：US10849988B2
公开(公告)日：2020-12-01
申请号：US16092202
申请日：2017-04-10
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Tatiana Segura , Donald Griffin , Philip Scumpia
IPC: A61K38/00 , A61K39/00 , A61K39/12 , A61K47/69 , A61K39/39 , A61L27/38 , A61L27/18 , A61L27/54 , A61L27/58 , A61L27/50 , A61L26/00 , A61L27/20 , A61L27/52 , A61L27/56 , A61K47/60 , A61P17/02 , A61K38/06 , A61K38/48 , A61K39/02
Abstract: An immune-modulating biomaterial comprising a hydrogel scaffold coupled to D-amino acid containing peptides having unexpected properties in vivo is described. For example, certain inflammatory reactions in vivo are significantly increased around the D-peptide containing particles of hydrogel scaffold as compared to particles that contain both L and D peptides or L peptides alone. In addition, these D-peptide compositions are further observed to enhance wound healing and improve the tensile strength of healed tissues. For these and other reasons, the D-amino acid hydrogel materials disclosed herein are useful in a number of methodologies that seek to modulate the immune response and/or wound healing.
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公开(公告)号：US20170368224A1
公开(公告)日：2017-12-28
申请号：US15701113
申请日：2017-09-11
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Donald R. Griffin , Westbrook Weaver , Tatiana Segura , Dino Di Carlo , Philip Scumpia
CPC classification number: A61L26/008 , A61L26/0019 , A61L26/0047 , A61L26/0066 , A61L26/0085 , A61L26/009 , A61L27/18 , A61L27/227 , A61L27/52 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/252 , A61L2300/412 , A61L2400/06 , A61L2430/00 , A61L2430/34 , C08L71/02
Abstract: A microporous gel system for certain applications, including biomedical applications, includes an aqueous solution containing plurality of microgel particles including a biodegradable crosslinker. In some aspects, the microgel particles act as gel building blocks that anneal to one another to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. In certain aspects, annealing of the microgel particles occurs after exposure to an annealing agent that is endogenously present or exogenously added. In some embodiments, annealing of the microgel particles requires the presence of an initiator such as exposure to light. In particular embodiments, the chemical and physical properties of the gel building blocks can be controlled to allow downstream control of the resulting assembled scaffold. In one or more embodiments, cells are able to quickly infiltrate the interstitial spaces of the assembled scaffold.
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Patent Agency Ranking
公开(公告)号：US11931480B2
公开(公告)日：2024-03-19
申请号：US16077985
申请日：2017-02-14
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Dino Di Carlo , Westbrook Weaver , Tatiana Segura , Philip Scumpia , Donald R. Griffin
CPC classification number: A61L27/52 , A61K9/0019 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K39/39 , A61L27/54 , A61L27/56 , C08H1/00 , A61K2039/60 , A61K2039/6093 , A61L2300/426 , A61L2300/64 , A61L2400/06
Abstract: A hydrogel material for modulating an immune response in a human subject or other mammal includes a collection of microgel particles having one or more network cross linker components, wherein the microgel particles, when exposed to an endogenous or exogenous annealing agent, links the microgel particles together in situ to form a covalently-stabilized scaffold of microgel particles having interstitial spaces formed between the microgel particles and wherein the collection of microgel particles further includes at least one of an antigen and an adjuvant.
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公开(公告)号：US20190151497A1
公开(公告)日：2019-05-23
申请号：US16264466
申请日：2019-01-31
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Donald R. Griffin , Westbrook Weaver , Tatiana Segura , Dino Di Carlo , Philip Scumpia
Abstract: A microporous gel system for certain applications, including biomedical applications, includes an aqueous solution containing plurality of microgel particles including a biodegradable crosslinker. In some aspects, the microgel particles act as gel building blocks that anneal to one another to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. In certain aspects, annealing of the microgel particles occurs after exposure to an annealing agent that is endogenously present or exogenously added. In some embodiments, annealing of the microgel particles requires the presence of an initiator such as exposure to light. In particular embodiments, the chemical and physical properties of the gel building blocks can be controlled to allow downstream control of the resulting assembled scaffold. In one or more embodiments, cells are able to quickly infiltrate the interstitial spaces of the assembled scaffold.
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8.发明申请公开(公告)号：US20160279283A1
公开(公告)日：2016-09-29
申请号：US15179151
申请日：2016-06-10
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Donald R. Griffin , Westbrook Weaver , Tatiana Segura , Dino Di Carlo , Philip Scumpia
CPC classification number: A61L26/008 , A61L26/0019 , A61L26/0047 , A61L26/0066 , A61L26/0085 , A61L26/009 , A61L27/18 , A61L27/227 , A61L27/52 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/252 , A61L2300/412 , A61L2400/06 , A61L2430/00 , A61L2430/34 , C08L71/02
Abstract: A microporous gel system for certain applications, including biomedical applications, includes an aqueous solution containing plurality of microgel particles including a biodegradable crosslinker. In some aspects, the microgel particles act as gel building blocks that anneal to one another to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. In certain aspects, annealing of the microgel particles occurs after exposure to an annealing agent that is endogenously present or exogenously added. In some embodiments, annealing of the microgel particles requires the presence of an initiator such as exposure to light. In particular embodiments, the chemical and physical properties of the gel building blocks can be controlled to allow downstream control of the resulting assembled scaffold. In one or more embodiments, cells are able to quickly infiltrate the interstitial spaces of the assembled scaffold.
Abstract translation: 用于某些应用（包括生物医学应用）的微孔凝胶体系包括含有多个包含可生物降解交联剂的微凝胶颗粒的水溶液。 在一些方面，微凝胶颗粒作为凝胶结构单元，其彼此退火以形成其中具有间隙空间的微凝胶颗粒的共价稳定的支架。 在某些方面，微凝胶颗粒的退火在暴露于内源存在或外源添加的退火剂之后发生。 在一些实施方案中，微凝胶颗粒的退火需要引发剂的存在，例如暴露于光。 在具体实施方案中，可以控制凝胶结构单元的化学和物理性质以允许下游控制所得的组装的支架。 在一个或多个实施方案中，细胞能够快速渗透组装的支架的间隙空间。
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公开(公告)号：US20230190995A1
公开(公告)日：2023-06-22
申请号：US17935096
申请日：2022-09-24
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Donald R. Griffin , Westbrook Weaver , Tatiana Segura , Dino Di Carlo , Philip Scumpia
IPC: A61L26/00 , A61L27/18 , A61L27/58 , A61K47/62 , A61K9/06 , A61K31/795 , A61L27/22 , A61L27/52 , A61L27/54 , A61L27/56
CPC classification number: A61L26/008 , A61L26/0019 , A61L26/0085 , A61L26/009 , A61L27/18 , A61L27/58 , A61K47/62 , A61K9/06 , A61K31/795 , A61L26/0066 , A61L26/0047 , A61L27/227 , A61L27/52 , A61L27/54 , A61L27/56 , A61L2430/34 , A61L2300/252 , A61L2300/412 , A61L2400/06 , A61L2430/00
Abstract: A microporous gel system for certain applications, including biomedical applications, includes an aqueous solution containing plurality of microgel particles including a biodegradable crosslinker. In some aspects, the microgel particles act as gel building blocks that anneal to one another to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. In certain aspects, annealing of the microgel particles occurs after exposure to an annealing agent that is endogenously present or exogenously added. In some embodiments, annealing of the microgel particles requires the presence of an initiator such as exposure to light. In particular embodiments, the chemical and physical properties of the gel building blocks can be controlled to allow downstream control of the resulting assembled scaffold. In one or more embodiments, cells are able to quickly infiltrate the interstitial spaces of the assembled scaffold.
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公开(公告)号：US20210138105A1
公开(公告)日：2021-05-13
申请号：US17144158
申请日：2021-01-08
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Donald R. Griffin , Westbrook Weaver , Tatiana Segura , Dino Di Carlo , Philip Scumpia
IPC: A61L26/00 , A61L27/18 , A61L27/58 , A61K47/62 , A61K9/06 , A61K31/795 , A61L27/22 , A61L27/52 , A61L27/54 , A61L27/56
Abstract: A microporous gel system for certain applications, including biomedical applications, includes an aqueous solution containing plurality of microgel particles including a biodegradable crosslinker. In some aspects, the microgel particles act as gel building blocks that anneal to one another to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. In certain aspects, annealing of the microgel particles occurs after exposure to an annealing agent that is endogenously present or exogenously added. In some embodiments, annealing of the microgel particles requires the presence of an initiator such as exposure to light. In particular embodiments, the chemical and physical properties of the gel building blocks can be controlled to allow downstream control of the resulting assembled scaffold. In one or more embodiments, cells are able to quickly infiltrate the interstitial spaces of the assembled scaffold.
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