公开(公告)号：US11660012B2

公开(公告)日：2023-05-30

申请号：US16093930

申请日：2017-04-17

Applicant: The Regents of the University of California

Inventor： Bryan Nowroozi ,  Warren S. Grundfest ,  Zachary Taylor ,  James Garritano ,  Priyamvada Tewari ,  Shijun Sung ,  Neha Bajwa

IPC: A61B5/0507 ,  A61B5/00 ,  A61B5/05 ,  G01B11/24 ,  A61B5/055

CPC classification number: A61B5/0507 ,  A61B5/00 ,  A61B5/0035 ,  A61B5/0077 ,  A61B5/05 ,  A61B5/445 ,  A61B5/0002 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/055 ,  A61B5/4878 ,  G01B11/24

Abstract: Systems, methods and apparatuses for performing wound analysis using THz imaging are provided. Due to the large complex component of water's dielectric constant in the THz regime, and the relative frequency invariance of non-aqueous tissue constituents, this modality is highly sensitive to the water content of tissue. It has been found that using THz imaging turns the presence of edema into a contrast mechanism, and allows for the use of the spatial distributions of edema to assess wound status immediately. Apparatus and methods enable earlier diagnosis of wound status which could result in accelerated treatment and shorter overall hospital stays.

公开(公告)号：US20190082998A1

公开(公告)日：2019-03-21

申请号：US16093930

申请日：2017-04-17

Applicant: The Regents of the University of California

Inventor： Bryan Nowroozi ,  Warren S. Grundfest ,  Zachary Taylor ,  James Garritano ,  Priyamvada Tewari ,  Shijun Sung ,  Neha Bajwa

IPC: A61B5/05 ,  A61B5/00

Abstract: Systems, methods and apparatuses for performing wound analysis using THz imaging are provided. Due to the large complex component of water's dielectric constant in the THz regime, and the relative frequency invariance of non-aqueous tissue constituents, this modality is highly sensitive to the water content of tissue. It has been found that using THz imaging turns the presence of edema into a contrast mechanism, and allows for the use of the spatial distributions of edema to assess wound status immediately. Apparatus and methods enable earlier diagnosis of wound status which could result in accelerated treatment and shorter overall hospital stays.

公开(公告)号：US20190117109A1

公开(公告)日：2019-04-25

申请号：US16093953

申请日：2017-04-17

Applicant: The Regents of the University of California

Inventor： Warren S. Grundfest ,  Zachary Taylor ,  James Garritano ,  Bryan Nowroozi ,  Neha Bajwa ,  Shijun Sung

IPC: A61B5/05 ,  A61B5/00 ,  A61B3/10 ,  A61B3/00

Abstract: Methods and apparatus for corneal imaging and sensing are provided. Apparatus capable of utilizing single or multiple frequency emissions at terahertz (THz) wavelengths to create reflectivity maps of the cornea in either a contact or non-contact modes are also provided. Methods of obtaining data from THz imaging and sensing apparatus about the corneal tissue-aqueous humor system, including information about the corneal tissue water content (CTWC) and/or the central corneal thickness (CCT) are likewise provided. Methodologies may use multiple transfer functions (frequencies) in obtaining simultaneous data about CTWC and CCT. Methods using frequency sweeping to allow for determination of CTWC and CCT may also be utilized. Methods may also be used to assess CTWC using multiple bandwidths at the same frequency, or multiple frequencies at the same bandwidth. Methods may use data from CTWC measurements to aid in the diagnosis of various corneal and brain disorders.

公开(公告)号：US10939844B2

公开(公告)日：2021-03-09

申请号：US16093953

申请日：2017-04-17

Applicant: The Regents of the University of California

Inventor： Warren S. Grundfest ,  Zachary Taylor ,  James Garritano ,  Bryan Nowroozi ,  Neha Bajwa ,  Shijun Sung

IPC: A61B3/10 ,  A61B3/14 ,  A61B3/02 ,  A61B3/00 ,  A61B5/0507 ,  A61B5/00 ,  G01B11/24 ,  A61B8/10

Abstract: Methods and apparatus for corneal imaging and sensing are provided. Apparatus capable of utilizing single or multiple frequency emissions at terahertz (THz) wavelengths to create reflectivity maps of the cornea in either a contact or non-contact modes are also provided. Methods of obtaining data from THz imaging and sensing apparatus about the corneal tissue-aqueous humor system, including information about the corneal tissue water content (CTWC) and/or the central corneal thickness (CCT) are likewise provided. Methodologies may use multiple transfer functions (frequencies) in obtaining simultaneous data about CTWC and CCT. Methods using frequency sweeping to allow for determination of CTWC and CCT may also be utilized. Methods may also be used to assess CTWC using multiple bandwidths at the same frequency, or multiple frequencies at the same bandwidth. Methods may use data from CTWC measurements to aid in the diagnosis of various corneal and brain disorders.

公开(公告)号：US20190029756A1

公开(公告)日：2019-01-31

申请号：US16072979

申请日：2017-01-26

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Shyam Natarajan ,  Alan Martin Priester ,  James Garritano ,  Leonard Marks ,  Warren Grundfest ,  Rory Geoghegan

IPC: A61B18/24 ,  A61B5/055 ,  A61B5/00 ,  A61B10/02 ,  A61B34/10 ,  A61B8/12 ,  A61B8/08

Abstract: The present invention provides methods of determining cancer margins indicating the location and breadth of treatment necessary for the elimination of cancerous tissue during focal laser therapy. The present invention also provides systems and devices for focal laser therapy, and methods for using the same. The present invention does not rely on MRI thermometry, improving accuracy of treatment while also reducing treatment time and cost.