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1.发明申请AN AUTOMATED, MULTI-POT HIGH-PRESSURE RADIO-SYNTHESIZER FOR PRODUCTION OF PET TRACERS 审中-公开用于生产PET拖拉机的自动多压高压无线电合成器公开(公告)号：US20160280734A1
公开(公告)日：2016-09-29
申请号：US14777973
申请日：2014-03-26
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Melissa Moore , R. Michael Van Dam , Kevin Quinn , Shane Claggett , Henry Herman , Mark Lazari
CPC classification number: C07H17/02 , B01J14/00 , B01J19/004 , B01J19/0093 , B01J2219/00799 , B01J2219/00801 , B01J2219/00813 , B01J2219/00815 , B01J2219/00817 , B01J2219/00831 , B01J2219/00873 , B01J2219/00889 , B01J2219/00909 , B01J2219/00918 , B01J2219/0097 , B01J2219/00986
Abstract: An automated radiosynthesizer device includes a plurality of reactor assemblies, each reactor assembly being operatively connected to a horizontal actuator for moving the reactor assembly in the horizontal direction and a vertical actuator for moving the reactor assembly in the vertical direction. A plurality of disposable cassettes are disposed above each of the plurality of reactor assemblies, each cassette comprising a lower surface comprising a plurality of sealed and un-sealed gaskets, wherein the un-sealed gaskets are connected to internal fluid paths within the cassette. The device includes a three-axis reagent and gas handling robot disposed above the plurality of cassettes and terminates in a vial gripper and a gas manifold having an inert gas port and a vacuum port. The device includes a control system configured to control the horizontal actuator and vertical actuator of each reactor assembly and the three-axis reagent and gas handling robot.
Abstract translation: 一种自动放射合成装置包括多个反应器组件，每个反应器组件可操作地连接到水平致动器，用于在水平方向上移动反应器组件;以及垂直致动器，用于沿垂直方向移动反应堆组件。 多个一次性盒被设置在多个反应器组件的每一个上方，每个盒包括下表面，该下表面包括多个密封和未密封的垫圈，其中未密封的垫片连接到盒内的内部流体路径。 该装置包括三轴试剂和气体处理机器人，其设置在多个盒的上方并且终止于小瓶夹持器和具有惰性气体端口和真空端口的气体歧管。 该装置包括控制系统，其配置成控制每个反应器组件和三轴试剂和气体处理机器人的水平致动器和垂直致动器。
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公开(公告)号：US10081005B2
公开(公告)日：2018-09-25
申请号：US14777973
申请日：2014-03-26
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Melissa Moore , R. Michael Van Dam , Kevin Quinn , Shane Claggett , Henry Herman , Mark Lazari
CPC classification number: B01J19/004 , B01J14/00 , B01J19/0093 , B01J2219/00799 , B01J2219/00801 , B01J2219/00813 , B01J2219/00815 , B01J2219/00817 , B01J2219/00831 , B01J2219/00873 , B01J2219/00889 , B01J2219/00909 , B01J2219/00918 , B01J2219/0097 , B01J2219/00986 , C07H17/02
Abstract: An automated radiosynthesizer device includes a plurality of reactor assemblies, each reactor assembly being operatively connected to a horizontal actuator for moving the reactor assembly in the horizontal direction and a vertical actuator for moving the reactor assembly in the vertical direction. A plurality of disposable cassettes are disposed above each of the plurality of reactor assemblies, each cassette comprising a lower surface comprising a plurality of sealed and un-sealed gaskets, wherein the un-sealed gaskets are connected to internal fluid paths within the cassette. The device includes a three-axis reagent and gas handling robot disposed above the plurality of cassettes and terminates in a vial gripper and a gas manifold having an inert gas port and a vacuum port. The device includes a control system configured to control the horizontal actuator and vertical actuator of each reactor assembly and the three-axis reagent and gas handling robot.
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