公开(公告)号：US20160280734A1

公开(公告)日：2016-09-29

申请号：US14777973

申请日：2014-03-26

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Melissa Moore ,  R. Michael Van Dam ,  Kevin Quinn ,  Shane Claggett ,  Henry Herman ,  Mark Lazari

IPC: C07H17/02 ,  B01J14/00

CPC classification number: C07H17/02 ,  B01J14/00 ,  B01J19/004 ,  B01J19/0093 ,  B01J2219/00799 ,  B01J2219/00801 ,  B01J2219/00813 ,  B01J2219/00815 ,  B01J2219/00817 ,  B01J2219/00831 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00909 ,  B01J2219/00918 ,  B01J2219/0097 ,  B01J2219/00986

Abstract: An automated radiosynthesizer device includes a plurality of reactor assemblies, each reactor assembly being operatively connected to a horizontal actuator for moving the reactor assembly in the horizontal direction and a vertical actuator for moving the reactor assembly in the vertical direction. A plurality of disposable cassettes are disposed above each of the plurality of reactor assemblies, each cassette comprising a lower surface comprising a plurality of sealed and un-sealed gaskets, wherein the un-sealed gaskets are connected to internal fluid paths within the cassette. The device includes a three-axis reagent and gas handling robot disposed above the plurality of cassettes and terminates in a vial gripper and a gas manifold having an inert gas port and a vacuum port. The device includes a control system configured to control the horizontal actuator and vertical actuator of each reactor assembly and the three-axis reagent and gas handling robot.

Abstract translation: 一种自动放射合成装置包括多个反应器组件，每个反应器组件可操作地连接到水平致动器，用于在水平方向上移动反应器组件;以及垂直致动器，用于沿垂直方向移动反应堆组件。 多个一次性盒被设置在多个反应器组件的每一个上方，每个盒包括下表面，该下表面包括多个密封和未密封的垫圈，其中未密封的垫片连接到盒内的内部流体路径。 该装置包括三轴试剂和气体处理机器人，其设置在多个盒的上方并且终止于小瓶夹持器和具有惰性气体端口和真空端口的气体歧管。 该装置包括控制系统，其配置成控制每个反应器组件和三轴试剂和气体处理机器人的水平致动器和垂直致动器。

公开(公告)号：US10473668B2

公开(公告)日：2019-11-12

申请号：US15315369

申请日：2015-06-05

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  SOFIE BIOSCIENCES, INC.

Inventor： R. Michael Van Dam ,  Melissa Moore ,  Brandon Maraglia ,  Daniel Thompson

IPC: G01N33/60 ,  A61B6/03 ,  A61B6/00 ,  G21H5/02 ,  G21G1/00 ,  G21F5/015

Abstract: A self-shielded, bench-top radiochemistry system, including a radioactive isotope dispensing module configured to draw an isotope out of a vial and dispense one or more metered doses of the isotope to a concentration module that concentrates the metered dose into a droplet amount of isotope and a synthesizer module that delivers the droplet amount of isotope along with one or more reagents to an electrowetting on dielectrics (EWOD) chip to produce a radiolabeled molecule.

公开(公告)号：US20170102391A1

公开(公告)日：2017-04-13

申请号：US15315369

申请日：2015-06-05

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  SOFIE BIOSCIENCES, INC.

Inventor： R. Michael Van Dam ,  Melissa Moore ,  Brandon Maraglia ,  Daniel Thompson

IPC: G01N33/60 ,  G21G1/00 ,  G21H5/02 ,  A61B6/03 ,  A61B6/00

CPC classification number: G01N33/60 ,  A61B6/037 ,  A61B6/48 ,  A61B6/542 ,  C07B59/00 ,  G21F5/015 ,  G21G1/0005 ,  G21H5/02

Abstract: A self-shielded, bench-top radiochemistry system, including a radioactive isotope dispensing module configured to draw an isotope out of a vial and dispense one or more metered doses of the isotope to a concentration module that concentrates the metered dose into a droplet amount of isotope and a synthesizer module that delivers the droplet amount of isotope along with one or more reagents to an electrowetting on dielectrics (EWOD) chip to produce a radiolabeled molecule.

公开(公告)号：US10081005B2

公开(公告)日：2018-09-25

申请号：US14777973

申请日：2014-03-26

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Melissa Moore ,  R. Michael Van Dam ,  Kevin Quinn ,  Shane Claggett ,  Henry Herman ,  Mark Lazari

IPC: B01J19/00 ,  B01J14/00 ,  C07H17/02

CPC classification number: B01J19/004 ,  B01J14/00 ,  B01J19/0093 ,  B01J2219/00799 ,  B01J2219/00801 ,  B01J2219/00813 ,  B01J2219/00815 ,  B01J2219/00817 ,  B01J2219/00831 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00909 ,  B01J2219/00918 ,  B01J2219/0097 ,  B01J2219/00986 ,  C07H17/02

Abstract: An automated radiosynthesizer device includes a plurality of reactor assemblies, each reactor assembly being operatively connected to a horizontal actuator for moving the reactor assembly in the horizontal direction and a vertical actuator for moving the reactor assembly in the vertical direction. A plurality of disposable cassettes are disposed above each of the plurality of reactor assemblies, each cassette comprising a lower surface comprising a plurality of sealed and un-sealed gaskets, wherein the un-sealed gaskets are connected to internal fluid paths within the cassette. The device includes a three-axis reagent and gas handling robot disposed above the plurality of cassettes and terminates in a vial gripper and a gas manifold having an inert gas port and a vacuum port. The device includes a control system configured to control the horizontal actuator and vertical actuator of each reactor assembly and the three-axis reagent and gas handling robot.

公开(公告)号：US20180065103A1

公开(公告)日：2018-03-08

申请号：US15698350

申请日：2017-09-07

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  SOFIE BIOSCIENCES, INC.

Inventor： Eric Schopf ,  Melissa Moore ,  R. Michael van Dam ,  Brandon Maraglia ,  Alexander Hsiao

IPC: B01J19/00 ,  B01J19/24

CPC classification number: B01J19/004 ,  A61K2121/00 ,  B01J19/24 ,  B01J2219/00164 ,  B01J2219/00191 ,  G21F7/04 ,  G21G1/0005 ,  G21G4/08

Abstract: A device for purifying and formulating a radiopharmaceutical compound includes an automated purification subsystem that automates the loading of a sample into a sample loop for downstream purification via HPLC. A column selector valve is provided to select from one of a plurality of columns. Fractions can be collected as well as the desired product. The device includes an automated formulation subsystem that first sends the product to a dilution reservoir prior to being pneumatically pushed onto a solid phase extraction (SPE) cartridge. Automated rinse, elution, and reconstitution are also performed with the automated formulation subsystem. The device may be directly coupled to the output of an automated radiosynthesizer.

公开(公告)号：US10589250B2

公开(公告)日：2020-03-17

申请号：US15698350

申请日：2017-09-07

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  SOFIE BIOSCIENCES, INC.

Inventor： Eric Schopf ,  Melissa Moore ,  R. Michael van Dam ,  Brandon Maraglia ,  Alexander Hsiao

IPC: B01J19/00 ,  B01J19/24 ,  G21G4/08 ,  G21G1/00 ,  G21F7/04

Abstract: A device for purifying and formulating a radiopharmaceutical compound includes an automated purification subsystem that automates the loading of a sample into a sample loop for downstream purification via HPLC. A column selector valve is provided to select from one of a plurality of columns. Fractions can be collected as well as the desired product. The device includes an automated formulation subsystem that first sends the product to a dilution reservoir prior to being pneumatically pushed onto a solid phase extraction (SPE) cartridge. Automated rinse, elution, and reconstitution are also performed with the automated formulation subsystem. The device may be directly coupled to the output of an automated radiosynthesizer.