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公开(公告)号：US20220255356A1
公开(公告)日：2022-08-11
申请号：US17628868
申请日：2020-07-22
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Peter Tseng , Manik Dautta , Muhannad Alshetaiwi
Abstract: A sensor device includes an inner hydrogel layer, a first planar metallic structure adjacent to a first surface of the inner hydrogel layer, and a second planar metallic structure adjacent to a second surface of the inner hydrogel layer opposite to the first surface. A sensor device further includes an encasing layer at least partially enclosing at least one of the inner hydrogel layer, the first planar metallic structure, and the second planar metallic structure. A method for use of the sensor device includes receiving at least one environmental stimulus, modifying a capacitance of a hydrogel in response to the received environmental stimulus, and generating an electrical stimulus response based on the modified capacitance. The method further includes modifying the capacitance of the hydrogel by modifying a resonant frequency of the hydrogel.
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2.发明申请公开(公告)号：US20210018491A1
公开(公告)日：2021-01-21
申请号：US17033488
申请日：2020-09-25
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Dino Di Carlo , Peter Tseng , Ivan Pushkarsky
Abstract: A system for assaying forces applied by cells includes an optically transparent substrate comprising a soft material having a Young's modulus within the range of about 3 kPa to about 100 kPa. An array of molecular patterns is disposed on a surface of the optically transparent substrate, the molecular patterns include fluorophore-conjugated patterns adherent to cells. The system includes at least one light source configured to excite the fluorophore-conjugated patterns and an imaging device configured to capture fluorescent light emitted from the fluorophore-conjugated patterns. Dimensional changes in the size of the patterns are used to determine contractile forces imparted by cells located on the patterns.
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公开(公告)号：US20230314181A1
公开(公告)日：2023-10-05
申请号：US18021763
申请日：2021-08-20
Applicant: The Regents of the University of California
Inventor： Peter Tseng , Amirhossein Hajiaghajani
IPC: G01D5/22
Abstract: Systems and methods for passive and/or active wireless sensor networks with augmented telemetry using coupled magnetic resonances in accordance with embodiments of the invention are disclosed. In one embodiment, a wireless sensor network is provided, the wireless sensor network comprising a transmitter configured to couple with a reader, a receiver configured to couple with a sensor, wherein the sensor is configured to detect at least one parameter and generate sensor data, wherein the sensor data maps onto the receiver, and wherein the transmitter and the receiver are inductively coupled creating a link between the reader and the sensor.
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4.发明授权公开(公告)号：US10473644B2
公开(公告)日：2019-11-12
申请号：US16105627
申请日：2018-08-20
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Dino Di Carlo , Peter Tseng , Ivan Pushkarsky
Abstract: A system for assaying forces applied by cells includes an optically transparent substrate comprising a soft material having a Young's modulus within the range of about 3 kPa to about 100 kPa. An array of molecular patterns is disposed on a surface of the optically transparent substrate, the molecular patterns include fluorophore-conjugated patterns adherent to cells. The system includes at least one light source configured to excite the fluorophore-conjugated patterns and an imaging device configured to capture fluorescent light emitted from the fluorophore-conjugated patterns. Dimensional changes in the size of the patterns are used to determine contractile forces imparted by cells located on the patterns.
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5.发明授权公开(公告)号：US11592438B2
公开(公告)日：2023-02-28
申请号：US17496752
申请日：2021-10-07
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Dino Di Carlo , Peter Tseng , Ivan Pushkarsky
Abstract: A system for assaying forces applied by cells includes an optically transparent substrate comprising a soft material having a Young's modulus within the range of about 3 kPa to about 100 kPa. An array of molecular patterns is disposed on a surface of the optically transparent substrate, the molecular patterns include fluorophore-conjugated patterns adherent to cells. The system includes at least one light source configured to excite the fluorophore-conjugated patterns and an imaging device configured to capture fluorescent light emitted from the fluorophore-conjugated patterns. Dimensional changes in the size of the patterns are used to determine contractile forces imparted by cells located on the patterns.
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Patent Agency Ranking
6.发明授权公开(公告)号：US10816540B2
公开(公告)日：2020-10-27
申请号：US16584419
申请日：2019-09-26
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Dino Di Carlo , Peter Tseng , Ivan Pushkarsky
Abstract: A system for assaying forces applied by cells includes an optically transparent substrate comprising a soft material having a Young's modulus within the range of about 3 kPa to about 100 kPa. An array of molecular patterns is disposed on a surface of the optically transparent substrate, the molecular patterns include fluorophore-conjugated patterns adherent to cells. The system includes at least one light source configured to excite the fluorophore-conjugated patterns and an imaging device configured to capture fluorescent light emitted from the fluorophore-conjugated patterns. Dimensional changes in the size of the patterns are used to determine contractile forces imparted by cells located on the patterns.
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7.发明授权公开(公告)号：US11175280B2
公开(公告)日：2021-11-16
申请号：US17033488
申请日：2020-09-25
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Dino Di Carlo , Peter Tseng , Ivan Pushkarsky
Abstract: A system for assaying forces applied by cells includes an optically transparent substrate comprising a soft material having a Young's modulus within the range of about 3 kPa to about 100 kPa. An array of molecular patterns is disposed on a surface of the optically transparent substrate, the molecular patterns include fluorophore-conjugated patterns adherent to cells. The system includes at least one light source configured to excite the fluorophore-conjugated patterns and an imaging device configured to capture fluorescent light emitted from the fluorophore-conjugated patterns. Dimensional changes in the size of the patterns are used to determine contractile forces imparted by cells located on the patterns.
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8.发明申请公开(公告)号：US20200025745A1
公开(公告)日：2020-01-23
申请号：US16584419
申请日：2019-09-26
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Dino Di Carlo , Peter Tseng , Ivan Pushkarsky
Abstract: A system for assaying forces applied by cells includes an optically transparent substrate comprising a soft material having a Young's modulus within the range of about 3 kPa to about 100 kPa. An array of molecular patterns is disposed on a surface of the optically transparent substrate, the molecular patterns include fluorophore-conjugated patterns adherent to cells. The system includes at least one light source configured to excite the fluorophore-conjugated patterns and an imaging device configured to capture fluorescent light emitted from the fluorophore-conjugated patterns. Dimensional changes in the size of the patterns are used to determine contractile forces imparted by cells located on the patterns.
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9.发明申请公开(公告)号：US20170176415A1
公开(公告)日：2017-06-22
申请号：US15300021
申请日：2015-03-27
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Dino Di Carlo , Peter Tseng , Ivan Pushkarsky
IPC: G01N33/50 , B01L3/00 , G01N21/64 , G01N33/487
CPC classification number: G01N33/5026 , B01L3/5085 , B01L2300/0654 , B01L2300/0829 , B01L2300/168 , G01L1/247 , G01N21/6458 , G01N33/487 , G01N33/582 , G01N2021/6419 , G01N2021/6441
Abstract: A system for assaying forces applied by cells includes an optically transparent substrate comprising a soft material having a Young's modulus within the range of about 3 kPa to about 100 kPa. An array of molecular patterns is disposed on a surface of the optically transparent substrate, the molecular patterns include fluorophore-conjugated patterns adherent to cells. The system includes at least one light source configured to excite the fluorophore-conjugated patterns and an imaging device configured to capture fluorescent light emitted from the fluorophore-conjugated patterns. Dimensional changes in the size of the patterns are used to determine contractile forces imparted by cells located on the patterns.
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公开(公告)号：US20240319126A1
公开(公告)日：2024-09-26
申请号：US18579317
申请日：2022-05-13
Applicant: The Regents of the University of California
Inventor： Peter Tseng , Manik Dautta , Kazi Khurshidi Haque Dia , Amirhossein Hajiaghajani
CPC classification number: G01N27/221 , G01N27/227 , G01N33/02
Abstract: The present embodiments relate to the multi-scale engineering of silk biopolymer-interlayer sensors for co-monitoring of nutrients. By manipulating various nano- to meso-structural properties of such biosensors, obtained are sensors with programmable sensitivity and selectivity to salts, sugars, and oils/fats. Notably, this approach requires no specialized nanomaterials or delicate biomolecules. Programmable biosensors are further formatted for wireless readout, and characteristics of these passive, wireless nutrient monitors are studied in-vitro. It is anticipated that such sensors can be utilized in emerging dictary tools for applications across food tracking and human health. In addition, it is expected that such strategies in structural engineering of sensors can be adaptable to existing or emerging selective or partially-selective sensors.
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