公开(公告)号：US11660571B2

公开(公告)日：2023-05-30

申请号：US16461272

申请日：2017-11-14

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： R. Michael van Dam ,  Noel S. Ha ,  Jason Jones ,  Jimmy Ly ,  Stephen Liu ,  Shilin Cheung

IPC: B01D57/02 ,  G01N27/447 ,  A61K51/00 ,  B01L3/00

CPC classification number: B01D57/02 ,  A61K51/00 ,  B01L3/502715 ,  B01L3/502738 ,  G01N27/44717 ,  G01N27/44721 ,  G01N27/44743 ,  G01N27/44791

Abstract: A microfluidic chip device for the purification of radiochemical compounds includes a chip having an injection channel and intersecting branch channels with a plurality of valves are located along the injection channel and branch channels and configured to retain a plug of solution containing the radiochemical compound. The chip further includes a serpentine channel segment (for separation) coupled to the output of the injection channel. A high voltage power source advances the plug of solution through the purification region and into the downstream fraction collection channel. The chip includes a downstream fraction collection channel coupled to the serpentine channel segment and having an optical and radiation detection regions. One or more branch fraction channels intersect with the fraction collection channel and include valves located therein so that the radiochemical compound that is detected using a radiation detector is directed into the desired branch fraction channel for subsequent use.

公开(公告)号：US20200147548A1

公开(公告)日：2020-05-14

申请号：US16461272

申请日：2017-11-14

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： R. Michael van Dam ,  Noel S. Ha ,  Jason Jones ,  Jimmy Ly ,  Stephen Liu ,  Shilin Cheung

IPC: B01D57/02 ,  A61K51/00

Abstract: A microfluidic chip device for the purification of radiochemical compounds includes a chip having an injection channel and intersecting branch channels with a plurality of valves are located along the injection channel and branch channels and configured to retain a plug of solution containing the radiochemical compound. The chip further includes a serpentine channel segment (for separation) coupled to the output of the injection channel. A high voltage power source advances the plug of solution through the purification region and into the downstream fraction collection channel. The chip includes a downstream fraction collection channel coupled to the serpentine channel segment and having an optical and radiation detection regions. One or more branch fraction channels intersect with the fraction collection channel and include valves located therein so that the radiochemical compound that is detected using a radiation detector is directed into the desired branch fraction channel for subsequent use.