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公开(公告)号：US20180065103A1
公开(公告)日：2018-03-08
申请号：US15698350
申请日：2017-09-07
Inventor： Eric Schopf , Melissa Moore , R. Michael van Dam , Brandon Maraglia , Alexander Hsiao
CPC classification number: B01J19/004 , A61K2121/00 , B01J19/24 , B01J2219/00164 , B01J2219/00191 , G21F7/04 , G21G1/0005 , G21G4/08
Abstract: A device for purifying and formulating a radiopharmaceutical compound includes an automated purification subsystem that automates the loading of a sample into a sample loop for downstream purification via HPLC. A column selector valve is provided to select from one of a plurality of columns. Fractions can be collected as well as the desired product. The device includes an automated formulation subsystem that first sends the product to a dilution reservoir prior to being pneumatically pushed onto a solid phase extraction (SPE) cartridge. Automated rinse, elution, and reconstitution are also performed with the automated formulation subsystem. The device may be directly coupled to the output of an automated radiosynthesizer.
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公开(公告)号：US20220401960A1
公开(公告)日：2022-12-22
申请号：US17622206
申请日：2020-08-07
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： R. Michael van Dam , Jia Wang , Alejandra Rios , Philip Chao , Jason Jones
Abstract: A radiosynthesis system is disclosed that leverages droplet microfluidic radiosynthesis and its inherent advantages including reduction of reagent consumption and the ability to achieve high molar activity even when using low starting radioactivity. The radiosynthesis system enables the parallel synthesis of radiolabeled compounds using droplet-sized reaction volumes. In some embodiments, a single heater is used to create multiple reaction or synthesis sites. In other embodiments, separate heaters are used to create independently-controlled heating conditions at the multiple reaction or synthesis sites. In one embodiment, a four-heater setup was developed that utilizes a multi-reaction microfluidic chip and was assessed for the suitability with high-throughput radiosynthesis optimization. Replicates of several radiochemical operations including the full synthesis of various PET tracers revealed the platform to have high repeatability (e.g., consistent fluorination efficiency). The system may also be used for synthesis optimization.
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公开(公告)号：US10589250B2
公开(公告)日：2020-03-17
申请号：US15698350
申请日：2017-09-07
Inventor： Eric Schopf , Melissa Moore , R. Michael van Dam , Brandon Maraglia , Alexander Hsiao
Abstract: A device for purifying and formulating a radiopharmaceutical compound includes an automated purification subsystem that automates the loading of a sample into a sample loop for downstream purification via HPLC. A column selector valve is provided to select from one of a plurality of columns. Fractions can be collected as well as the desired product. The device includes an automated formulation subsystem that first sends the product to a dilution reservoir prior to being pneumatically pushed onto a solid phase extraction (SPE) cartridge. Automated rinse, elution, and reconstitution are also performed with the automated formulation subsystem. The device may be directly coupled to the output of an automated radiosynthesizer.
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Patent Agency Ranking
公开(公告)号：US20220251025A1
公开(公告)日：2022-08-11
申请号：US17612206
申请日：2020-05-22
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： R. Michael van Dam , Jia Wang
IPC: C07C227/16 , B01L9/00 , C07B59/00 , B01J19/00 , B01L3/00
Abstract: A chemical synthesis platform based on a particularly simple chip is described herein, where reactions take place atop a hydrophobic substrate patterned with a circular hydrophilic liquid trap. The overall supporting hardware (heater, rotating carousel of reagent dispensers, etc.) can be packaged into a very compact format (about the size of a coffee cup). We demonstrate the consistent synthesis of [18F]fallypride with high yield, and show that protocols optimized using a high-throughput optimization platform we have developed can be readily translated to this device with no changes or reoptimization.
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公开(公告)号：US20190201560A1
公开(公告)日：2019-07-04
申请号：US16325376
申请日：2017-09-06
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Philip Hong-Sean Chao , R. Michael van Dam
CPC classification number: A61K51/02 , A61B6/037 , A61K51/0446 , A61K51/0459 , A61K51/0491 , B01L3/502753 , B01L2300/0681 , B01L2300/0883 , B01L2300/12 , C07B59/00
Abstract: A method of formulating or concentrating a radiolabeled molecule or compound includes providing a microfluidic device having a sample layer containing a microfluidic channel formed therein, a porous membrane having a pore size of less than 0.5 μm disposed on the sample layer and covering the microfluidic channel, and a gas flow layer having a gas-carrying channel formed therein, wherein the porous membrane is interposed between the sample layer and the gas flow layer. A fluid containing the radiolabeled molecule or compound is delivered into the microfluidic channel. Heat is applied to evaporate the fluid. A gas is passed through gas-carrying channel to remove evaporated fluid from the microfluidic device.
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公开(公告)号：US12078625B2
公开(公告)日：2024-09-03
申请号：US17605213
申请日：2020-04-15
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： R. Michael van Dam , Jia Wang , Alejandra Rios
Abstract: A method of performing high-throughput radio thin layer chromatography (radio-TLC) includes spotting a plurality of locations on one or more TLC plates with samples containing a radiochemical or a radiopharmaceutical, each location defining an individual lane on the one or more TLC plates for the respective samples. The one or more TLC plates are developed with a developing solution and dried. The TLC plates are imaged with an imaging device comprising a camera, wherein the image obtained from the camera comprises a field of view that contains regions of interest (ROIs) from the plurality of lanes. The ROIs in the images obtained from the camera may then be analyzed by the user. The ROIs may be used, for example, reaction optimization or for quality control check of the production of radiotracers.
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公开(公告)号：US11660571B2
公开(公告)日：2023-05-30
申请号：US16461272
申请日：2017-11-14
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： R. Michael van Dam , Noel S. Ha , Jason Jones , Jimmy Ly , Stephen Liu , Shilin Cheung
IPC: B01D57/02 , G01N27/447 , A61K51/00 , B01L3/00
CPC classification number: B01D57/02 , A61K51/00 , B01L3/502715 , B01L3/502738 , G01N27/44717 , G01N27/44721 , G01N27/44743 , G01N27/44791
Abstract: A microfluidic chip device for the purification of radiochemical compounds includes a chip having an injection channel and intersecting branch channels with a plurality of valves are located along the injection channel and branch channels and configured to retain a plug of solution containing the radiochemical compound. The chip further includes a serpentine channel segment (for separation) coupled to the output of the injection channel. A high voltage power source advances the plug of solution through the purification region and into the downstream fraction collection channel. The chip includes a downstream fraction collection channel coupled to the serpentine channel segment and having an optical and radiation detection regions. One or more branch fraction channels intersect with the fraction collection channel and include valves located therein so that the radiochemical compound that is detected using a radiation detector is directed into the desired branch fraction channel for subsequent use.
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公开(公告)号：US20200147548A1
公开(公告)日：2020-05-14
申请号：US16461272
申请日：2017-11-14
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： R. Michael van Dam , Noel S. Ha , Jason Jones , Jimmy Ly , Stephen Liu , Shilin Cheung
Abstract: A microfluidic chip device for the purification of radiochemical compounds includes a chip having an injection channel and intersecting branch channels with a plurality of valves are located along the injection channel and branch channels and configured to retain a plug of solution containing the radiochemical compound. The chip further includes a serpentine channel segment (for separation) coupled to the output of the injection channel. A high voltage power source advances the plug of solution through the purification region and into the downstream fraction collection channel. The chip includes a downstream fraction collection channel coupled to the serpentine channel segment and having an optical and radiation detection regions. One or more branch fraction channels intersect with the fraction collection channel and include valves located therein so that the radiochemical compound that is detected using a radiation detector is directed into the desired branch fraction channel for subsequent use.
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