公开(公告)号：US09784258B2

公开(公告)日：2017-10-10

申请号：US14029286

申请日：2013-09-17

Applicant: The Regents of The University of California

Inventor： Elliot E. Hui ,  Philip N. Duncan ,  Transon V. Nguyen

IPC: F04B19/00 ,  F16K99/00 ,  F04B43/12 ,  F04B53/10

CPC classification number: F04B19/006 ,  F04B43/12 ,  F04B53/10 ,  F16K99/0015 ,  F16K99/0034 ,  F16K99/0059 ,  F16K2099/0094

Abstract: Microfluidic oscillator circuits and pumps for microfluidic devices are provided. The microfluidic pump may include a plurality of fluid valves and a microfluidic oscillator circuit having an oscillation frequency. The fluid valves may be configured to move fluids. Each fluid valve may be connected to a node of the microfluidic oscillator circuit. The pumps may be driven by the oscillator circuits such that fluid movement is accomplished entirely by circuits on a microfluidic chip, without the need for off-chip controls.

公开(公告)号：US20210379592A1

公开(公告)日：2021-12-09

申请号：US17403513

申请日：2021-08-16

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Elliot En-Yu Hui ,  Erik Morgan Werner ,  Philip N. Duncan ,  Transon V. Nguyen ,  Siavash Ahrar

IPC: B01L3/00

Abstract: This invention describes a design for a multiwell plate that contains integrated pumps that are used to stir each well of the plate. The device employs microfluidic logic technology to drive each peristaltic pump. This enables the plates to run autonomously, requiring only a static vacuum supply for power. The devices are entirely constructed out of low-cost polymers, with no electronics, and yet contains simple digital logic circuits to control the pumps. A stack of these plates may be run continuously in a standard cell culture incubator, allowing high-throughput culture of organoids.

公开(公告)号：US20190153376A1

公开(公告)日：2019-05-23

申请号：US16254835

申请日：2019-01-23

Applicant: The Regents of the University of California

Inventor： Elliot En-Yu Hui ,  Erik Morgan Werner ,  Philip N. Duncan ,  Transon V. Nguyen ,  Siavash Ahrar

IPC: C12M1/02 ,  F04B43/12 ,  C12M3/06 ,  C12M1/32 ,  C12M1/00 ,  C12M1/34 ,  C12M1/36

Abstract: This invention describes a design for a multiwell plate that contains integrated pumps that are used to stir each well of the plate. The device employs microfluidic logic technology to drive each peristaltic pump. This enables the plates to run autonomously, requiring only a static vacuum supply for power. The devices are entirely constructed out of low-cost polymers, with no electronics, and yet contains simple digital logic circuits to control the pumps. A stack of these plates may be run continuously in a standard cell culture incubator, allowing high-throughput culture of organoids.

公开(公告)号：US20140079571A1

公开(公告)日：2014-03-20

申请号：US14029286

申请日：2013-09-17

Applicant: The Regents of the University of California

Inventor： Elliot E. Hui ,  Philip N. Duncan ,  Transon V. Nguyen

IPC: F04B19/00 ,  F16K99/00

CPC classification number: F04B19/006 ,  F04B43/12 ,  F04B53/10 ,  F16K99/0015 ,  F16K99/0034 ,  F16K99/0059 ,  F16K2099/0094

Abstract: Microfluidic oscillator circuits and pumps for microfluidic devices are provided. The microfluidic pump may include a plurality of fluid valves and a microfluidic oscillator circuit having an oscillation frequency. The fluid valves may be configured to move fluids. Each fluid valve may be connected to a node of the microfluidic oscillator circuit. The pumps may be driven by the oscillator circuits such that fluid movement is accomplished entirely by circuits on a microfluidic chip, without the need for off-chip controls.

Abstract translation: 提供微流体振荡器电路和用于微流体装置的泵。 微流体泵可以包括多个流体阀和具有振荡频率的微流体振荡器电路。 流体阀可以构造成移动流体。 每个流体阀可以连接到微流体振荡器电路的节点。 泵可以由振荡器电路驱动，使得流体运动完全由微流控芯片上的电路完成，而不需要片外控制。