公开(公告)号：US20230145564A1

公开(公告)日：2023-05-11

申请号：US17911132

申请日：2021-03-23

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Alireza Khademhosseini ,  Wujin Sun ,  Xingwu Zhou

IPC: A61M37/00 ,  A61K9/00 ,  A61K9/70 ,  A61K47/42 ,  A61K47/40 ,  A61K31/12

CPC classification number: A61M37/0015 ,  A61K9/0021 ,  A61K9/7084 ,  A61K31/12 ,  A61K47/40 ,  A61K47/42 ,  A61M2037/0023 ,  A61M2037/0046

Abstract: A patch incorporates biodegradable microneedles (MNs) that are fabricated from naturally derived polymer conjugates of gelatin methacryloyl and β-cyclodextrin (GelMA-)β-CD). When curcumin, an unstable and water-insoluble anticancer therapeutic agent, is loaded as an example, its stability and solubility are improved due to the formation of inclusion complex. The polymer-drug complex GelMA-β-CD/CUR can be formulated into MN arrays with sufficient mechanical strength for skin penetration and tunable drug release profile. Anticancer efficacy of released curcumin is observed in three-dimensional (3D) B16F10 melanoma models. The GelMA-β-CD/CUR MN exhibits relatively higher therapeutic efficacy through more localized and deeper penetrated manner compared with a control non-transdermal patch. In vivo studies verify biocompatibility and degradability of the GelMA-β-CD MN-based patch. Other water-insoluble therapeutic agents may be loaded into the patch.