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1.发明公开公开(公告)号：US20230331935A1
公开(公告)日：2023-10-19
申请号：US18042598
申请日：2021-09-16
Inventor： Alireza Khademhosseini , Shiming Zhang , Sourav Saha , Mehmet R. Dokmeci , Lu Jiang
CPC classification number: C08J3/075 , A61B5/1477 , A61B5/14507 , A61B5/14546 , A61F9/0017 , G02B1/043 , G02C7/049 , B29D11/00048 , B29D11/00096 , C08J2333/10 , C08J2481/08 , B29K2105/0061
Abstract: Microchannels in hydrogels play an essential role in enabling a smart contact lens. A wearable contact lens is disclosed herein that uses microchannels and connected chambers located in poly-2-hydroxyethyl methacrylate (poly(HEMA)) hydrogel that is used in a commercial contact lens with three-dimensional (3D) printed mold. The corresponding capillary flow behaviors in these microchannels were investigated. Different capillary flow regimes were observed in these microchannels, depending on the hydration level of the hydrogel material. In particular, it was found that a peristaltic pressure could reinstate flow in a dehydrated microchannel, indicating the motion of eye-blinking may help tear flow in a microchannel-containing contact lens. Colorimetric pH and electrochemical Na+ sensing capabilities were demonstrated in these microchannels. Micro-engineered contact lenses formed using poly(HEMA) hydrogel can be used for various biomedical applications such as eye-care and wearable biosensing.
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公开(公告)号：US20230321419A1
公开(公告)日：2023-10-12
申请号：US17791452
申请日：2021-01-07
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Alireza Khademhosseini , Wujin Sun
IPC: A61M37/00
CPC classification number: A61M37/0015 , A61M2037/0061
Abstract: A gelatin-based (e.g., gelatin methacryloyl (GelMA)) patch is disclosed with an array of microneedles (MNs) for minimally invasive sampling of bodily fluids such as interstitial fluid (ISF). The properties of the patch can be tuned by altering the concentration of the GelMA prepolymer and the crosslinking time. The GelMA-based MN patch demonstrated efficient extraction of ISF. Furthermore, in experimental testing, the patch efficiently and quantitatively detects glucose and vancomycin in ISF in an in vivo study. This minimally invasive approach of extracting ISF with a GelMA microneedle enables to detection and analysis of target molecules from patients. The target molecules captured in the patch may be released and analyzed to detect the presence of and/or concentration of target molecules. In other embodiments, the patch itself may be analyzed directly to detect the presence of and/or concentration of target molecules.
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公开(公告)号：US20230277080A1
公开(公告)日：2023-09-07
申请号：US18040115
申请日：2021-08-17
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Alireza Khademhosseini , Shiming Zhang , Zhikang Li
CPC classification number: A61B5/053 , A61B5/024 , C08L89/06 , A61B5/681 , A61B2562/12 , A61B2562/0247
Abstract: A gelatin methacryloyl (GelMA)-based biosensor device for wearable biosensing applications is disclosed. An exemplary capacitive tactile sensor with GelMA used as the core dielectric layer is disclosed. A robust chemical bonding and a reliable encapsulation approach are introduced to overcome detachment and water-evaporation issues in hydrogel biosensors. The resultant GelMA tactile sensor shows a high-pressure sensitivity of 0.19 kPa−1 and one order of magnitude lower limit of detection (0.1 Pa) compared to previous hydrogel pressure sensors owing to its excellent mechanical and electrical properties (e.g., dielectric constant). Furthermore, it shows durability up to 3,000 test cycles because of tough chemical bonding, and long-term stability of three (3) days due to the inclusion of an encapsulation layer, which prevents water evaporation (e.g., 80% water content). Successful monitoring of various human physiological and motion signals demonstrates the potential of the GelMA biosensor device for wearable biosensing applications.
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公开(公告)号：US20230145564A1
公开(公告)日：2023-05-11
申请号：US17911132
申请日：2021-03-23
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Alireza Khademhosseini , Wujin Sun , Xingwu Zhou
CPC classification number: A61M37/0015 , A61K9/0021 , A61K9/7084 , A61K31/12 , A61K47/40 , A61K47/42 , A61M2037/0023 , A61M2037/0046
Abstract: A patch incorporates biodegradable microneedles (MNs) that are fabricated from naturally derived polymer conjugates of gelatin methacryloyl and β-cyclodextrin (GelMA-)β-CD). When curcumin, an unstable and water-insoluble anticancer therapeutic agent, is loaded as an example, its stability and solubility are improved due to the formation of inclusion complex. The polymer-drug complex GelMA-β-CD/CUR can be formulated into MN arrays with sufficient mechanical strength for skin penetration and tunable drug release profile. Anticancer efficacy of released curcumin is observed in three-dimensional (3D) B16F10 melanoma models. The GelMA-β-CD/CUR MN exhibits relatively higher therapeutic efficacy through more localized and deeper penetrated manner compared with a control non-transdermal patch. In vivo studies verify biocompatibility and degradability of the GelMA-β-CD MN-based patch. Other water-insoluble therapeutic agents may be loaded into the patch.
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公开(公告)号：US20230321316A1
公开(公告)日：2023-10-12
申请号：US18044357
申请日：2021-09-02
Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , BOSTON SCIENTIFIC SCIMED, INC.
Inventor： Rahmi Oklu , Alireza Khademhosseini , Ehsan Jabbarzadeh
CPC classification number: A61L24/0005 , A61L24/02 , A61L24/0068 , A61L24/001 , A61L2430/36 , A61L2400/12 , A61L2400/06
Abstract: This disclosure relates to methods and materials for embolization of one or more blood vessels (e.g., one or more arteries). For example, biomaterial compositions (e.g., BEM compositions containing PRF and one or more nanoclay materials) for embolization of one or more blood vessels (e.g., one or more arteries) within a mammal (e.g., a human) are provided.
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Patent Agency Ranking
公开(公告)号：US20210403649A1
公开(公告)日：2021-12-30
申请号：US17279283
申请日：2019-10-18
Applicant: The Regents of the University of California
Inventor： Amir Sheikhi , Dino Di Carlo , Alireza Khademhosseini , Joseph de Rutte
Abstract: Despite the significant advances in designing injectable bulk hydrogels, the inability to control the pore interconnectivity and decoupling it from the matrix stiffness has tremendously limited the applicability of stiff, flowable hydrogels for 3D cellular engineering. To address this problem, we developed a universal method to convert macromolecules and the like with orthogonal chemical and/or physical responsivity, e.g., thermosensitive macromolecules with chemically-crosslinkable moieties, into annealable building blocks, forming 3D microporous beaded scaffolds in a bottom-up approach. For example, gelatin methacryloyl (GelMA), a widely used biomaterial in tissue engineering, may be converted into physically-crosslinked microbeads using a facile microfluidic approach, followed by flow of the microbead slurry and chemical crosslinking in situ to fabricate microporous beaded GelMA (B-GelMA) scaffolds with interconnected pores, promoting cell functionality and rapid (within minutes) 3D seeding in stiff scaffolds, which are otherwise impossible in the bulk gel counterparts.
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7.发明公开公开(公告)号：US20230397853A1
公开(公告)日：2023-12-14
申请号：US18249716
申请日：2021-10-26
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Alireza Khademhosseini , Shiming Zhang
IPC: A61B5/1473 , H10K10/46 , G01N27/414 , A61B5/00
CPC classification number: A61B5/14735 , H10K10/484 , G01N27/4145 , A61B5/6852 , A61B5/685 , A61B5/6801 , A61B2562/164
Abstract: An organic electrochemical transistor (OECT)-based sensor device is disclosed that uses circular-shaped gate electrode and source and drain electrodes that at least partially surround the gate electrode and have an undulating pattern that is generally described as curvy and wavy (CW). The arrangement of the source and drain electrodes around the gate electrode provides the ability to obtain high-transconductance OECT (HT-OECT). With the HT-OECT sensor design, multiplexed OECT-based biosensors can be created for high-throughput screening applications of multiple biomarkers/biomolecules. This platform can be used for point-of-care applications, wearable biosensing, and minimally-invasive biosensing with microneedles or a catheter/probe as a carrier for HT-OECT(s).
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公开(公告)号：US20230256219A1
公开(公告)日：2023-08-17
申请号：US18007039
申请日：2021-07-28
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Alireza Khademhosseini , Wujin Sun
CPC classification number: A61M37/0015 , A61K9/0021 , A61K47/6949 , A61M2037/0023 , A61M2037/0061
Abstract: A biodegradable microneedle (MN) patch is disclosed for transdermal gene delivery. The MN patch, in one embodiment, is a gelatin methacryloyl (GelMA)-based MN platform for the local and controlled transdermal delivery of plasmid DNA (pDNA) (or other nucleic acid with high transfection efficiency both in vitro and in vivo. Intracellular delivery of the nucleic acid cargo is enabled by poly(β-amino ester) (PBAE). After being embedded in the GelMA MNs, sustained release of DNA-encapsulated PBAE nanoparticles (NPs) is achieved and the release profiles can be controlled by adjusting the degree of crosslinking of the GelMA. These results highlight the advantages and potential of using PBAE/DNA NPs embedded GelMA MN patches (MN/PBAE/DNA) for successful transdermal delivery of pDNA for tissue regeneration, cancer therapy, and other applications. The patch may also be used on other tissue types.
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公开(公告)号：US20220218867A1
公开(公告)日：2022-07-14
申请号：US17608706
申请日：2020-05-20
Applicant: The Regents of the University of California
Inventor： Amir Sheikhi , Nasim Annabi , Alireza Khademhosseini
Abstract: Naturally-derived biopolymers, such as proteins and polysaccharides are a promising platform for developing materials that readily adhere to tissues upon chemical crosslinking and provide a regenerative microenvironment. Here, we show that the sealing properties of a model biopolymer sealant, gelatin methacryloyl (GelMA), can be precisely controlled by adding a small amount of a synthetic polymer with identically reactive moieties, i.e., poly (ethylene glycol) diacrylate (PEG DA). For example, we have discovered a more than 300% improvement in tissue sealing capability of 20% (w/v) GelMA adhesive can be obtained by adding only 2-3% (v/v) PEGDA, without any significant effect on the sealant degradation time scale. These hybrid hydrogels with improved sealing properties are suitable for sealing stretchable organs, such as bladder, as well as for the anastomosis of tubular tissues/organs.
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公开(公告)号：US20210386985A1
公开(公告)日：2021-12-16
申请号：US17286443
申请日：2019-10-28
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Alireza Khademhosseini , Wujin Sun
Abstract: A microneedle patch is described that can be used for the sustained delivery of therapeutic agents into living tissue (e.g., skin). The polymer (gelatin methacryloyl (GelMA)) patch can adjust delivery rates based on the degree of crosslinking. The anticancer drug Doxorubicin (DOX) was loaded into GelMA microneedles using a molding fabrication technique. The GelMA microneedles efficiently penetrated the stratum corneum layer of a mouse cadaver skin. Mechanical properties and therapeutic agent release behavior of the GelMA microneedles can be adjusted by tuning the degree of crosslinking. The efficacy of the DOX released from the GelMA microneedles was tested and demonstrated the anticancer efficacy of the released drugs against melanoma cell line A375. Because GelMA is versatile material in engineering tissue scaffolds, GelMA microneedles can be used as a platform for the delivery of various types of therapeutic agents to tissue.
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