公开(公告)号：US20230277080A1

公开(公告)日：2023-09-07

申请号：US18040115

申请日：2021-08-17

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Alireza Khademhosseini ,  Shiming Zhang ,  Zhikang Li

IPC: A61B5/053 ,  A61B5/024 ,  C08L89/06 ,  A61B5/00

CPC classification number: A61B5/053 ,  A61B5/024 ,  C08L89/06 ,  A61B5/681 ,  A61B2562/12 ,  A61B2562/0247

Abstract: A gelatin methacryloyl (GelMA)-based biosensor device for wearable biosensing applications is disclosed. An exemplary capacitive tactile sensor with GelMA used as the core dielectric layer is disclosed. A robust chemical bonding and a reliable encapsulation approach are introduced to overcome detachment and water-evaporation issues in hydrogel biosensors. The resultant GelMA tactile sensor shows a high-pressure sensitivity of 0.19 kPa−1 and one order of magnitude lower limit of detection (0.1 Pa) compared to previous hydrogel pressure sensors owing to its excellent mechanical and electrical properties (e.g., dielectric constant). Furthermore, it shows durability up to 3,000 test cycles because of tough chemical bonding, and long-term stability of three (3) days due to the inclusion of an encapsulation layer, which prevents water evaporation (e.g., 80% water content). Successful monitoring of various human physiological and motion signals demonstrates the potential of the GelMA biosensor device for wearable biosensing applications.