公开(公告)号：US20240049483A1

公开(公告)日：2024-02-08

申请号：US18042197

申请日：2021-08-25

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Alireza Khademhosseini ,  Shiming Zhang

IPC: H10K10/46 ,  G01L1/00

CPC classification number: H10K10/471 ,  G01L1/005

Abstract: A low power-consumption iontronic pressure sensor is disclosed that is based on OECT where an ionic hydrogel is used as solid gating medium for pressure sensing transistor elements formed thereon. The pressure sensor includes a substrate containing one or more pressure sensing transistor elements with each transistor element including a source electrode, a drain electrode, and a channel formed from a material comprising an electrically conducting polymer. A microstructured solid gel electrolyte having a plurality of microstructures formed thereon serves as the gating medium and is disposed atop the channel. A gate electrode is disposed on the microstructured solid gel electrolyte. The resultant iontronic pressure sensor may be operated at voltages less than 1 V, with a power-consumption between ˜101-103 μW, while maintaining a tunable sensitivity between 1˜10 kPa−1.

公开(公告)号：US20230397853A1

公开(公告)日：2023-12-14

申请号：US18249716

申请日：2021-10-26

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Alireza Khademhosseini ,  Shiming Zhang

IPC: A61B5/1473 ,  H10K10/46 ,  G01N27/414 ,  A61B5/00

CPC classification number: A61B5/14735 ,  H10K10/484 ,  G01N27/4145 ,  A61B5/6852 ,  A61B5/685 ,  A61B5/6801 ,  A61B2562/164

Abstract: An organic electrochemical transistor (OECT)-based sensor device is disclosed that uses circular-shaped gate electrode and source and drain electrodes that at least partially surround the gate electrode and have an undulating pattern that is generally described as curvy and wavy (CW). The arrangement of the source and drain electrodes around the gate electrode provides the ability to obtain high-transconductance OECT (HT-OECT). With the HT-OECT sensor design, multiplexed OECT-based biosensors can be created for high-throughput screening applications of multiple biomarkers/biomolecules. This platform can be used for point-of-care applications, wearable biosensing, and minimally-invasive biosensing with microneedles or a catheter/probe as a carrier for HT-OECT(s).

公开(公告)号：US20230331935A1

公开(公告)日：2023-10-19

申请号：US18042598

申请日：2021-09-16

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  COOPERVISION INTERNATIONAL LIMITED

Inventor： Alireza Khademhosseini ,  Shiming Zhang ,  Sourav Saha ,  Mehmet R. Dokmeci ,  Lu Jiang

IPC: C08J3/075 ,  A61B5/1477 ,  A61B5/145 ,  A61F9/00 ,  G02B1/04 ,  G02C7/04 ,  B29D11/00

CPC classification number: C08J3/075 ,  A61B5/1477 ,  A61B5/14507 ,  A61B5/14546 ,  A61F9/0017 ,  G02B1/043 ,  G02C7/049 ,  B29D11/00048 ,  B29D11/00096 ,  C08J2333/10 ,  C08J2481/08 ,  B29K2105/0061

Abstract: Microchannels in hydrogels play an essential role in enabling a smart contact lens. A wearable contact lens is disclosed herein that uses microchannels and connected chambers located in poly-2-hydroxyethyl methacrylate (poly(HEMA)) hydrogel that is used in a commercial contact lens with three-dimensional (3D) printed mold. The corresponding capillary flow behaviors in these microchannels were investigated. Different capillary flow regimes were observed in these microchannels, depending on the hydration level of the hydrogel material. In particular, it was found that a peristaltic pressure could reinstate flow in a dehydrated microchannel, indicating the motion of eye-blinking may help tear flow in a microchannel-containing contact lens. Colorimetric pH and electrochemical Na+ sensing capabilities were demonstrated in these microchannels. Micro-engineered contact lenses formed using poly(HEMA) hydrogel can be used for various biomedical applications such as eye-care and wearable biosensing.

公开(公告)号：US20230277080A1

公开(公告)日：2023-09-07

申请号：US18040115

申请日：2021-08-17

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Alireza Khademhosseini ,  Shiming Zhang ,  Zhikang Li

IPC: A61B5/053 ,  A61B5/024 ,  C08L89/06 ,  A61B5/00

CPC classification number: A61B5/053 ,  A61B5/024 ,  C08L89/06 ,  A61B5/681 ,  A61B2562/12 ,  A61B2562/0247

Abstract: A gelatin methacryloyl (GelMA)-based biosensor device for wearable biosensing applications is disclosed. An exemplary capacitive tactile sensor with GelMA used as the core dielectric layer is disclosed. A robust chemical bonding and a reliable encapsulation approach are introduced to overcome detachment and water-evaporation issues in hydrogel biosensors. The resultant GelMA tactile sensor shows a high-pressure sensitivity of 0.19 kPa−1 and one order of magnitude lower limit of detection (0.1 Pa) compared to previous hydrogel pressure sensors owing to its excellent mechanical and electrical properties (e.g., dielectric constant). Furthermore, it shows durability up to 3,000 test cycles because of tough chemical bonding, and long-term stability of three (3) days due to the inclusion of an encapsulation layer, which prevents water evaporation (e.g., 80% water content). Successful monitoring of various human physiological and motion signals demonstrates the potential of the GelMA biosensor device for wearable biosensing applications.