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公开(公告)号：US20230340106A1
公开(公告)日：2023-10-26
申请号：US17946941
申请日：2022-09-16
申请人： Pfizer Inc. , The Regents of the University of California , The Board of Trustees of the Leland Stanford Junior University
发明人： Isaac J. Rondon , Natasha Crellin , Paul Bessette , Eleonora Trotta , Jeffrey A. Bluestone , Lauren K. Ely , Kenan C. Garcia
IPC分类号： C07K16/24
CPC分类号： C07K16/246 , C07K2317/76 , C07K2317/21 , C07K2317/51 , A61K2039/505
摘要： The present invention provides antibodies, or antigen-binding portions thereof, which specifically bind to IL-2 and reduce the affinity of IL-2 binding to IL-2Rα and IL-2Rβ. The invention further provides a method of obtaining such antibodies and nucleic acids encoding the same. The invention further relates to compositions and therapeutic methods for use of these antibodies for the treatment and/or prevention of autoimmune diseases, disorders or conditions and for immunosuppression, including, but not limited to, administering a complex comprising the antibody and IL-2.
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公开(公告)号：US11066481B2
公开(公告)日：2021-07-20
申请号：US15746305
申请日：2016-07-22
发明人： Thomas Mikita , Lauren K. Ely , Huilan Gao , Yun Kim , Isaac J. Rondon , Tovo David , Shaun R. Coughlin
IPC分类号： C07K16/36
摘要： In one aspect, antibodies, or antigen-binding fragments thereof, that specifically bind to activated Factor XI (FXIa) are provided. Also provided are methods of obtaining such antibodies and nucleic acids encoding the same. In another aspect, compositions and therapeutic prevention of thrombotic diseases, disorders or conditions are provided. In another aspect, anti-idiotype antibodies that bind anti-FXIa antibodies of the disclosure, as well as compositions comprising the anti-idiotype antibodies, methods of obtaining the antibodies and nucleic acids encoding the same, are also provided.
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公开(公告)号：US20210061902A1
公开(公告)日：2021-03-04
申请号：US16925227
申请日：2020-07-09
申请人： Pfizer Inc. , The Regents of the University of California , The Board of Trustees of the Leland Stanford Junior University
发明人： Isaac J. RONDON , Natasha Crellin , Paul Bessette , Eleonora Trotta , Jeffrey A. Bluestone , Lauren K. Ely , Kenan C. Garcia
IPC分类号： C07K16/24
摘要： The present invention provides antibodies, or antigen-binding portions thereof, which specifically bind to IL-2 and reduce the affinity of IL-2 binding to IL-2Rα and IL-2Rβ. The invention further provides a method of obtaining such antibodies and nucleic acids encoding the same. The invention further relates to compositions and therapeutic methods for use of these antibodies for the treatment and/or prevention of autoimmune diseases, disorders or conditions and for immunosuppression, including, but not limited to, administering a complex comprising the antibody and IL-2.
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公开(公告)号：US20170114130A1
公开(公告)日：2017-04-27
申请号：US15331038
申请日：2016-10-21
申请人： Pfizer Inc. , The Regents of the University of California , The Board of Trustees of the Leland Stanford Junior University
发明人： Isaac J. Rondon , Natasha Crellin , Paul Bessette , Eleonora Trotta , Jeffrey A. Bluestone , Lauren K. Ely , Kenan C. Garcia
IPC分类号： C07K16/24
CPC分类号： C07K16/246 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/51 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention provides antibodies, or antigen-binding portions thereof, which specifically bind to IL-2 and reduce the affinity of IL-2 binding to IL-2Rα and IL-2Rβ. The invention further provides a method of obtaining such antibodies and nucleic acids encoding the same. The invention further relates to compositions and therapeutic methods for use of these antibodies for the treatment and/or prevention of autoimmune diseases, disorders or conditions and for immunosuppression, including, but not limited to, administering a complex comprising the antibody and IL-2.
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公开(公告)号：US11459385B2
公开(公告)日：2022-10-04
申请号：US16925227
申请日：2020-07-09
申请人： Pfizer Inc. , The Regents of the University of California , The Board of Trustees of the Leland Stanford Junior University
发明人： Isaac J. Rondon , Natasha Crellin , Paul Bessette , Eleonora Trotta , Jeffrey A. Bluestone , Lauren K. Ely , Kenan C. Garcia
摘要： The present invention provides antibodies, or antigen-binding portions thereof, which specifically bind to IL-2 and reduce the affinity of IL-2 binding to IL-2Rα and IL-2Rβ. The invention further provides a method of obtaining such antibodies and nucleic acids encoding the same. The invention further relates to compositions and therapeutic methods for use of these antibodies for the treatment and/or prevention of autoimmune diseases, disorders or conditions and for immunosuppression, including, but not limited to, administering a complex comprising the antibody and IL-2.
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公开(公告)号：US20190106488A1
公开(公告)日：2019-04-11
申请号：US16133939
申请日：2018-09-18
申请人： Pfizer Inc. , The Regents of the University of California , The Board of Trustees of the Leland Stanford Junior University
发明人： Isaac J. Rondon , Natasha Crellin , Paul Bessette , Eleonora Trotta , Jeffrey A. Bluestone , Lauren K. Ely , Kenan C. Garcia
IPC分类号： C07K16/24
摘要： The present invention provides antibodies, or antigen-binding portions thereof, which specifically bind to IL-2 and reduce the affinity of IL-2 binding to IL-2Rα and IL-2Rβ. The invention further provides a method of obtaining such antibodies and nucleic acids encoding the same. The invention further relates to compositions and therapeutic methods for use of these antibodies for the treatment and/or prevention of autoimmune diseases, disorders or conditions and for immunosuppression, including, but not limited to, administering a complex comprising the antibody and IL-2.
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公开(公告)号：US10738113B2
公开(公告)日：2020-08-11
申请号：US16133939
申请日：2018-09-18
申请人： Pfizer Inc. , The Regents of the University of California , The Board of Trustees of the Leland Stanford Junior University
发明人： Isaac J. Rondon , Natasha Crellin , Paul Bessette , Eleonora Trotta , Jeffrey A. Bluestone , Lauren K. Ely , Kenan C. Garcia
摘要： The present invention provides antibodies, or antigen-binding portions thereof, which specifically bind to IL-2 and reduce the affinity of IL-2 binding to IL-2Rα and IL-2Rβ. The invention further provides a method of obtaining such antibodies and nucleic acids encoding the same. The invention further relates to compositions and therapeutic methods for use of these antibodies for the treatment and/or prevention of autoimmune diseases, disorders or conditions and for immunosuppression, including, but not limited to, administering a complex comprising the antibody and IL-2.
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公开(公告)号：US10138298B2
公开(公告)日：2018-11-27
申请号：US15331038
申请日：2016-10-21
申请人： Pfizer Inc. , The Regents of the University of California , The Board of Trustees of the Leland Stanford Junior University
发明人： Isaac J. Rondon , Natasha Crellin , Paul Bessette , Eleonora Trotta , Jeffrey A. Bluestone , Lauren K. Ely , Kenan C. Garcia
摘要： The present invention provides antibodies, or antigen-binding portions thereof, which specifically bind to IL-2 and reduce the affinity of IL-2 binding to IL-2Rα and IL-2Rβ. The invention further provides a method of obtaining such antibodies and nucleic acids encoding the same. The invention further relates to compositions and therapeutic methods for use of these antibodies for the treatment and/or prevention of autoimmune diseases, disorders or conditions and for immunosuppression, including, but not limited to, administering a complex comprising the antibody and IL-2.
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