公开(公告)号：US11141086B2

公开(公告)日：2021-10-12

申请号：US16611687

申请日：2018-05-08

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Issam I. El Naqa ,  Ibrahim Oraiqat ,  Roy Clarke ,  Nicholas Cucinelli ,  Samuel Debruin

IPC: G01T1/20 ,  A61B5/1455 ,  A61B5/00 ,  A61N5/10

Abstract: Cerenkov Emission (CE) during external beam radiation therapy (EBRT) from a linear accelerator (Linac) has been demonstrated as a useful tool for radiotherapy quality assurance and potentially other applications for online tracking of tumors during treatment. However, an overlooked area is the molecular probing of the cancer status during delivery mainly due to the limited detection sensitivity of CE and lack of flexible tools to fit into an already complex treatment delivery environment. Silicon photomultiplier (SiPM) can be used for low light detection due to their extreme sensitivity that mirrors photomultiplier tubes and yet has a form factor that is similar to silicon photodiodes, allowing for improved flexibility in device design. This work assesses the feasibility of using SiPMs to detect CE, interrogate the tumor molecular status during EBRT, and contrast its performance with silicon photodiodes (PDs) available commercially.

公开(公告)号：US20220212036A1

公开(公告)日：2022-07-07

申请号：US17600564

申请日：2020-05-11

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Issam El Naqa ,  Xueding Wang ,  Paul Carson ,  Kyle Cuneo ,  Jean Moran ,  Wei Zhang ,  Ibrahim Oraiqat

IPC: A61N5/10 ,  A61B8/08

Abstract: A method and system for performing online adapted radiotherapy are provided using combined ultrasound and ionizing radiation induced acoustic imaging (iRAI) computed tomography imaging techniques that can be used for measurement of low to ultrahigh dose deliveries (>40 Gy/s). Multiplexed transducers detect US and iRAI signals allowing for anatomical/functional imaging and radiation mapping with absolute dosimetry measurements of a region of interest during a radiotherapy session. Corrections to radiation dosage intensities and locations is determined and provided as feedback to a radiation source to improve the accuracy of applied radiation dosages intra- or inter-radiotherapy treatment sessions preventing the irradiation of healthy tissues and ensuring the accurate delivery of radiation to a tumor or region of interest.

公开(公告)号：US20250001211A1

公开(公告)日：2025-01-02

申请号：US18883578

申请日：2024-09-12

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Issam El Naqa ,  Xueding Wang ,  Paul Carson ,  Kyle Cuneo ,  Jean Moran ,  Wei Zhang ,  Ibrahim Oraiqat

IPC: A61N5/10 ,  A61B8/08

Abstract: A method and system for performing online adapted radiotherapy are provided using combined ultrasound and ionizing radiation induced acoustic imaging (iRAI) computed tomography imaging techniques that can be used for measurement of low to ultrahigh dose deliveries (>40 Gy/s). Multiplexed transducers detect US and iRAI signals allowing for anatomical/functional imaging and radiation mapping with absolute dosimetry measurements of a region of interest during a radiotherapy session. Corrections to radiation dosage intensities and locations is determined and provided as feedback to a radiation source to improve the accuracy of applied radiation dosages intra- or inter-radiotherapy treatment sessions preventing the irradiation of healthy tissues and ensuring the accurate delivery of radiation to a tumor or region of interest.

公开(公告)号：US12102843B2

公开(公告)日：2024-10-01

申请号：US17600564

申请日：2020-05-11

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Issam El Naqa ,  Xueding Wang ,  Paul Carson ,  Kyle Cuneo ,  Jean Moran ,  Wei Zhang ,  Ibrahim Oraiqat

IPC: A61N5/10 ,  A61B8/08

CPC classification number: A61N5/1067 ,  A61B8/08 ,  A61B8/485 ,  A61N5/1038 ,  A61N5/1039 ,  A61N5/1049 ,  A61N5/1071 ,  A61N2005/1054 ,  A61N2005/1058

Abstract: A method and system for performing online adapted radiotherapy are provided using combined ultrasound and ionizing radiation induced acoustic imaging (iRAI) computed tomography imaging techniques that can be used for measurement of low to ultrahigh dose deliveries (>40 Gy/s). Multiplexed transducers detect US and iRAI signals allowing for anatomical/functional imaging and radiation mapping with absolute dosimetry measurements of a region of interest during a radiotherapy session. Corrections to radiation dosage intensities and locations is determined and provided as feedback to a radiation source to improve the accuracy of applied radiation dosages intra- or inter-radiotherapy treatment sessions preventing the irradiation of healthy tissues and ensuring the accurate delivery of radiation to a tumor or region of interest.