公开(公告)号：US20240416348A1

公开(公告)日：2024-12-19

申请号：US18820655

申请日：2024-08-30

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： Arum Han ,  Adrian Guzman ,  Han Zhang ,  Jose Wippold ,  Jing Dai

IPC: B01L3/00

Abstract: A combination micro/macro-fluidic analysis system with one or more of a droplet transition unit, a droplet cleaving unit, a droplet synchronization, and a merging unit to enable highly efficient complex droplet microfluidic assays.

公开(公告)号：US11794188B2

公开(公告)日：2023-10-24

申请号：US17239456

申请日：2021-04-23

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： Arum Han ,  Adrian Guzman ,  Han Zhang ,  Jose Wippold ,  Jing Dai

IPC: B01L3/00

CPC classification number: B01L3/502784 ,  B01L2200/027 ,  B01L2200/0647 ,  B01L2200/12 ,  B01L2200/16 ,  B01L2400/086

Abstract: A combination micro/macro-fluidic analysis system with one or more of a droplet transition unit, a droplet cleaving unit, a droplet synchronization, and a merging unit to enable highly efficient complex droplet microfluidic assays.

公开(公告)号：US20240157362A1

公开(公告)日：2024-05-16

申请号：US18382591

申请日：2023-10-23

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： Arum Han ,  Adrian Guzman ,  Han Zhang ,  Jose Wippold ,  Jing Dai

IPC: B01L3/00

CPC classification number: B01L3/502784 ,  B01L2200/027 ,  B01L2200/0647 ,  B01L2200/12 ,  B01L2200/16 ,  B01L2400/086

Abstract: A combination micro/macro-fluidic analysis system with one or more of a droplet transition unit, a droplet cleaving unit, a droplet synchronization, and a merging unit to enable highly efficient complex droplet microfluidic assays.

公开(公告)号：US20220097066A1

公开(公告)日：2022-03-31

申请号：US17239456

申请日：2021-04-23

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： Arum Han ,  Adrian Guzman ,  Han Zhang ,  Jose Wippold ,  Jing Dai

IPC: B01L3/00

Abstract: A combination micro/macro-fluidic analysis system with one or more of a droplet transition unit, a droplet cleaving unit, a droplet synchronization, and a merging unit to enable highly efficient complex droplet microfluidic assays.

公开(公告)号：US12121900B2

公开(公告)日：2024-10-22

申请号：US18382591

申请日：2023-10-23

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： Arum Han ,  Adrian Guzman ,  Han Zhang ,  Jose Wippold ,  Jing Dai

IPC: B01L3/00

CPC classification number: B01L3/502784 ,  B01L2200/027 ,  B01L2200/0647 ,  B01L2200/12 ,  B01L2200/16 ,  B01L2400/086

Abstract: A combination micro/macro-fluidic analysis system with one or more of a droplet transition unit, a droplet cleaving unit, a droplet synchronization, and a merging unit to enable highly efficient complex droplet microfluidic assays.

公开(公告)号：US20220364120A1

公开(公告)日：2022-11-17

申请号：US17745488

申请日：2022-05-16

Applicant: The Texas A&M University System ,  U.S. Army Research Laboratory

Inventor： Arum Han ,  Jose Wippold ,  Bryn L. Adams

IPC: C12N15/88 ,  B01L3/00

Abstract: In an embodiment, the present disclosure pertains to a microfluidic platform composed of a droplet generator having an entry point for donor particles and target particles, a first droplet incubation chamber in fluid communication with the droplet generator, a droplet detection functionality to allow for analysis of the inner content of droplets, and a droplet sorting functionality to allow for the separation of droplets based on the analysis of the inner content of droplets. In another embodiment, the present disclosure pertains to a method for cell-to-cell DNA, RNA, or other genetic material transfer through use of a water-in-oil emulsion microdroplet-based microfluidic platform for automation and high throughput identification or screening of genetic transfer outcomes utilizing the microfluidic platforms as disclosed herein.