公开(公告)号：US20180021273A1

公开(公告)日：2018-01-25

申请号：US15655583

申请日：2017-07-20

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： Owen Anthony O'CONNOR ,  Jennifer Effie AMENGUAL ,  Donald W. LANDRY ,  Ottavio ARANCIO ,  Luigi SCOTTO ,  Shi Xian DENG ,  Rosa PURGATORIO ,  Jole FIORITO

IPC分类号： A61K31/167 ,  A61K38/15 ,  A61K31/4453 ,  A61K31/4035

CPC分类号： A61K31/167 ,  A61K31/18 ,  A61K31/381 ,  A61K31/4035 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/4453 ,  A61K31/495 ,  A61K31/505 ,  A61K31/535 ,  A61K31/5377 ,  A61K38/15 ,  A61K45/06 ,  A61K2300/00

摘要： The invention provides pharmaceutical compositions and methods for treating cancer, neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein by administering a HAT modulator and a HDAC modulator to a subject.

公开(公告)号：US20180360842A1

公开(公告)日：2018-12-20

申请号：US15868458

申请日：2018-01-11

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： Ottavio ARANCIO ,  Shi Xian DENG ,  Donald W. LANDRY ,  Jole FIORITO ,  Rosa PURGATORIO ,  Owen Anthony O'CONNOR ,  Jennifer Effie AMENGUAL

IPC分类号： A61K31/536 ,  C07C235/64 ,  C07C235/42 ,  C07D209/38 ,  C07D265/26 ,  C07D265/22 ,  A61K31/403 ,  A61K31/166 ,  C07D209/34 ,  C07C237/40

摘要： The invention provides compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a compound that modulates HAT to a subject.

公开(公告)号：US20230165813A1

公开(公告)日：2023-06-01

申请号：US17881340

申请日：2022-08-04

申请人： The Trustees of Columbia University in the City of New York

发明人： Owen Anthony O'CONNOR ,  Jennifer Effie AMENGUAL ,  Donald W. LANDRY ,  Ottavio ARANCIO ,  Luigi SCOTTO ,  Shixian DENG ,  Rosa PURGATORIO ,  Jole FIORITO

IPC分类号： A61K31/167 ,  A61K31/5377 ,  A61K31/44 ,  A61K31/381 ,  A61K45/06 ,  A61K31/535 ,  A61K31/4409 ,  A61K31/495 ,  A61K31/505 ,  A61K31/18 ,  A61K31/4035 ,  A61K31/4453 ,  A61K38/15

CPC分类号： A61K31/167 ,  A61K31/5377 ,  A61K31/44 ,  A61K31/381 ,  A61K45/06 ,  A61K31/535 ,  A61K31/4409 ,  A61K31/495 ,  A61K31/505 ,  A61K31/18 ,  A61K31/4035 ,  A61K31/4453 ,  A61K38/15

摘要： The invention provides pharmaceutical compositions and methods for treating cancer, neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein by administering a HAT modulator and a HDAC modulator to a subject.

公开(公告)号：US20200330410A1

公开(公告)日：2020-10-22

申请号：US16870584

申请日：2020-05-08

申请人： The Trustees of Columbia University in the City of New York

发明人： Owen Anthony O'CONNOR ,  Jennifer Effie AMENGUAL ,  Donald W. LANDRY ,  Ottavio ARANCIO ,  Luigi SCOTTO ,  Shixian DENG ,  Rosa PURGATORIO ,  Jole FIORITO

IPC分类号： A61K31/167 ,  A61K31/5377 ,  A61K31/44 ,  A61K31/381 ,  A61K45/06 ,  A61K31/535 ,  A61K31/4409 ,  A61K31/495 ,  A61K31/505 ,  A61K31/18 ,  A61K31/4035 ,  A61K31/4453 ,  A61K38/15

摘要： The invention provides pharmaceutical compositions and methods for treating cancer, neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein by administering a HAT modulator and a HDAC modulator to a subject.

公开(公告)号：US20170182054A1

公开(公告)日：2017-06-29

申请号：US15300497

申请日：2015-03-30

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： Ottavio ARANCIO ,  Shixian DENG ,  Donald W. LANDRY ,  Jole FIORITO ,  Rosa PURGATORIO ,  Owen Anthony O'CONNOR ,  Jennifer Effie AMENGUAL

IPC分类号： A61K31/536 ,  C07D265/22 ,  C07C237/40 ,  A61K31/166 ,  C07C235/64 ,  C07D209/38 ,  C07D209/34 ,  A61K31/403 ,  C07D265/26 ,  C07C235/42

CPC分类号： A61K31/536 ,  A61K31/166 ,  A61K31/403 ,  A61K2121/00 ,  C07C235/42 ,  C07C235/64 ,  C07C237/40 ,  C07D209/34 ,  C07D209/38 ,  C07D265/22 ,  C07D265/26

摘要： The invention provides compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a compound that modulates HAT to a subject.