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    NOVEL PHOSPHODIESTERASE INHIBITORS AND USES THEREOF
    3.
    发明申请
    NOVEL PHOSPHODIESTERASE INHIBITORS AND USES THEREOF 有权

    公开(公告)号：US20210130349A1

    公开(公告)日：2021-05-06

    申请号：US17137665

    申请日：2020-12-30

    申请人： The Trustees of Columbia University in the City of New York

    发明人： Donald W. LANDRY ,  Shixian DENG ,  Ottavio ARANCIO ,  Jole FIORITO ,  Andrew WASMUTH

    IPC分类号： C07D471/04 ,  C07D471/14

    摘要： The invention provides for novel benzonaphthyridine derivatives and compositions comprising novel benzonaphthyridine derivatives. In some embodiments, the compounds are phosphodiesterase inhibitors. The invention further provides for methods for inhibition of phosphodiesterase comprising contacting phosphodiesterase with novel benzonaphthyridine derivatives or compositions comprising novel benzonaphthyridine derivatives. The invention further provides for methods for treatment of neurodegenerative diseases, increasing memory or long term potentiation with novel benzonaphthyridine derivatives or compositions comprising novel benzonaphthyridine derivatives. In some embodiments, the phosphodiesterase is PDE5.