公开(公告)号：US20180021273A1

公开(公告)日：2018-01-25

申请号：US15655583

申请日：2017-07-20

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： Owen Anthony O'CONNOR ,  Jennifer Effie AMENGUAL ,  Donald W. LANDRY ,  Ottavio ARANCIO ,  Luigi SCOTTO ,  Shi Xian DENG ,  Rosa PURGATORIO ,  Jole FIORITO

IPC分类号： A61K31/167 ,  A61K38/15 ,  A61K31/4453 ,  A61K31/4035

CPC分类号： A61K31/167 ,  A61K31/18 ,  A61K31/381 ,  A61K31/4035 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/4453 ,  A61K31/495 ,  A61K31/505 ,  A61K31/535 ,  A61K31/5377 ,  A61K38/15 ,  A61K45/06 ,  A61K2300/00

摘要： The invention provides pharmaceutical compositions and methods for treating cancer, neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein by administering a HAT modulator and a HDAC modulator to a subject.

公开(公告)号：US20190201400A1

公开(公告)日：2019-07-04

申请号：US16293403

申请日：2019-03-05

申请人： The Trustees of Columbia University in the City of New York

发明人： Andrew WASMUTH ,  Donald W. LANDRY ,  Shi Xian DENG ,  Banavara L. MYLARI ,  Ravichandran RAMASAMY ,  Ann Marie SCHMIDT

IPC分类号： A61K31/5025 ,  C07D487/04

CPC分类号： A61K31/5025 ,  C07D487/04 ,  H05K999/99

摘要： The present invention relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, the treatment of angiogenesis disorders, such as cancer, treatment of tissue damage, such as non-cardiac tissue damage, the treatment of evolving myocardial infarction, and the treatment of various other disorders, such as complications arising from diabetes with the compounds and compositions of the invention. Other disorders can include, but are not limited to, atherosclerosis, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, infections of the skin, peripheral vascular disease, stroke, and the like.

公开(公告)号：US20180360842A1

公开(公告)日：2018-12-20

申请号：US15868458

申请日：2018-01-11

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： Ottavio ARANCIO ,  Shi Xian DENG ,  Donald W. LANDRY ,  Jole FIORITO ,  Rosa PURGATORIO ,  Owen Anthony O'CONNOR ,  Jennifer Effie AMENGUAL

IPC分类号： A61K31/536 ,  C07C235/64 ,  C07C235/42 ,  C07D209/38 ,  C07D265/26 ,  C07D265/22 ,  A61K31/403 ,  A61K31/166 ,  C07D209/34 ,  C07C237/40

摘要： The invention provides compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a compound that modulates HAT to a subject.

公开(公告)号：US20170319584A1

公开(公告)日：2017-11-09

申请号：US15661257

申请日：2017-07-27

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： Andrew WASMUTH ,  Donald W. LANDRY ,  Shi Xian DENG ,  Banavara L. MYLARI ,  Ravichandran RAMASAMY ,  Ann Marie SCHMIDT

IPC分类号： A61K31/5025 ,  C07D487/04

CPC分类号： A61K31/5025 ,  C07D487/04

摘要： The present invention relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, the treatment of angiogenesis disorders, such as cancer, treatment of tissue damage, such as non-cardiac tissue damage, the treatment of evolving myocardial infarction, and the treatment of various other disorders, such as complications arising from diabetes with the compounds and compositions of the invention. Other disorders can include, but are not limited to, atherosclerosis, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, infections of the skin, peripheral vascular disease, stroke, and the like.

公开(公告)号：US20150072989A1

公开(公告)日：2015-03-12

申请号：US14541365

申请日：2014-11-14

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： Andrew WASMUTH ,  Donald W. LANDRY ,  Shi Xian DENG ,  Banavara L. MYLARI ,  Ravichandran RAMASAMY ,  Ann Marie SCHMIDT

IPC分类号： C07D487/04

CPC分类号： A61K31/5025 ,  C07D487/04

摘要： The present invention relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, the treatment of angiogenesis disorders, such as cancer, treatment of tissue damage, such as non-cardiac tissue damage, the treatment of evolving myocardial infarction, and the treatment of various other disorders, such as complications arising from diabetes with the compounds and compositions of the invention. Other disorders can include, but are not limited to, atherosclerosis, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, infections of the skin, peripheral vascular disease, stroke, and the like.

摘要翻译： 本发明涉及新颖的化合物及其药物组合物，以及用于促进皮肤健康老化，皮肤病症治疗，心血管疾病治疗，肾脏疾病治疗，血管生成障碍如癌症治疗的治疗方法 的组织损伤，例如非心脏组织损伤，进展性心肌梗死的治疗，以及治疗各种其它疾病，例如由本发明的化合物和组合物引起的糖尿病并发症。 其它障碍可以包括但不限于动脉粥样硬化，冠状动脉疾病，糖尿病性肾病，糖尿病性神经病，糖尿病性视网膜病，皮肤感染，外周血管疾病，中风等。