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公开(公告)号：US11633145B2
公开(公告)日：2023-04-25
申请号：US17076788
申请日：2020-10-21
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Brian Pogue , Samuel Streeter , Benjamin Maloney , Keith Paulsen
Abstract: A surgical specimen imaging system includes a micro-X-ray computed tomography (CT) unit for CT imaging of the specimen and a structured light imaging (SLI) unit for optical imaging at multiple wavelengths, multiple phase offsets, and multiple structured-light pattern periods including unstructured light. The system's image processing unit receives CT and optical images and is configured by firmware in memory to co-register the images and process the optical images to determine texture at multiple subimages of the optical images, determined textures forming a texture map. The texture map is processed by a machine-learning-based classifier to determine a tissue type map of the specimen, and the tissue type map is processed with the CT images to give a 3D tissue-type map. In embodiments, the firmware extracts optical properties including scattering and absorption at multiple wavelengths and the classifier also uses these properties in generating the tissue type map.
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公开(公告)号：US20210113146A1
公开(公告)日：2021-04-22
申请号：US17076788
申请日：2020-10-21
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Brian Pogue , Samuel Streeter , Benjamin Maloney , Keith Paulsen
Abstract: A surgical specimen imaging system includes a micro-X-ray computed tomography (CT) unit for CT imaging of the specimen and a structured light imaging (SLI) unit for optical imaging at multiple wavelengths, multiple phase offsets, and multiple structured-light pattern periods including unstructured light. The system's image processing unit receives CT and optical images and is configured by firmware in memory to co-register the images and process the optical images to determine texture at multiple subimages of the optical images, determined textures forming a texture map. The texture map is processed by a machine-learning-based classifier to determine a tissue type map of the specimen, and the tissue type map is processed with the CT images to give a 3D tissue-type map. In embodiments, the firmware extracts optical properties including scattering and absorption at multiple wavelengths and the classifier also uses these properties in generating the tissue type map.
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3.发明申请Methods And Systems For Intraoperative Tumor Margin Assessment In Surgical Cavities And Resected Tissue Specimens 审中-公开手术腔和切除组织标本术中肿瘤边缘评估的方法与系统公开(公告)号：US20150150460A1
公开(公告)日：2015-06-04
申请号：US14406487
申请日：2013-06-07
Applicant: The Trustees of Dartmouth College
CPC classification number: A61B5/0075 , A61B1/00096 , A61B1/00165 , A61B1/00172 , A61B1/043 , A61B1/0646 , A61B1/07 , A61B5/0071 , A61B5/0084 , A61B5/4836 , A61B5/7264 , A61B5/7282
Abstract: A tissue classifying system uses central illumination while detecting scattered light received from one or more rings surrounding the central illumination. A broadband illuminator is used. Received light couples to a spectrographic detection system that provides data to a processor with machine readable instructions for determining a classification of a type of tissue illuminated by the system. A scanner is used to generate a map of tissue classification for use by a surgeon who may remove additional tissue from a surgical wound to ensure complete treatment. Embodiments include a scanner that maps tissue classification across tissue, and a scanner coupled to a coherent optical bundle that may be placed in contact with tissue along boundaries of an operative wound. Other embodiments are adapted to scan tissue for fluorescent emissions and/or polarization shifts between incident and scattered light.
Abstract translation: 组织分类系统使用中央照明，同时检测从围绕中央照明的一个或多个环接收的散射光。 使用宽带照明器。 接收光耦合到光谱检测系统，其向处理器提供用于确定由系统照亮的组织类型的分类的机器可读指令的数据。 扫描仪用于产生组织分类的图，以供外科医生使用，外科医生可以从手术伤口移除额外的组织以确保完全治疗。 实施例包括将组织分类对准组织的扫描仪和耦合到相干光束的扫描仪，扫描仪可以沿与手术伤口边界的组织放置成接触。 其他实施例适于扫描组织以进行入射和散射光之间的荧光发射和/或偏振移位。
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