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1.发明公开公开(公告)号：US20230280577A1
公开(公告)日：2023-09-07
申请号：US18144767
申请日：2023-05-08
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Pablo A. Valdes , David W. Roberts , Keith D. Paulsen , Frederic Leblond
Abstract: An imaging system includes an illumination device for illuminating a target. A surgical microscope receives light from the target, the surgical microscope comprising at least one optical output port at which at least a portion of the received light is provided as an output from the surgical microscope. A tunable filter receives the portion of the received light provided as the output from the surgical microscope, the tunable filter being tunable to pass a filtered portion of the received light, the filtered portion of the received light having a plurality of wavelengths selected by the tunable filter and provided as output from the tunable filter. A high-resolution, broad-bandwidth electronic camera receives the light of a plurality of wavelengths selected by the tunable filter, the electronic camera converting the light of a plurality of wavelengths selected by the tunable filter to a plurality of electrical signals. A processor processes the plurality of electrical signals to form an image of the target.
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Patent Agency Ranking
公开(公告)号：US12061328B2
公开(公告)日：2024-08-13
申请号：US18144767
申请日：2023-05-08
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Pablo A. Valdes , David W. Roberts , Keith D. Paulsen , Frederic Leblond
Abstract: An imaging system includes an illumination device for illuminating a target. A surgical microscope receives light from the target, the surgical microscope comprising at least one optical output port at which at least a portion of the received light is provided as an output from the surgical microscope. A tunable filter receives the portion of the received light provided as the output from the surgical microscope, the tunable filter being tunable to pass a filtered portion of the received light, the filtered portion of the received light having a plurality of wavelengths selected by the tunable filter and provided as output from the tunable filter. A high-resolution, broad-bandwidth electronic camera receives the light of a plurality of wavelengths selected by the tunable filter, the electronic camera converting the light of a plurality of wavelengths selected by the tunable filter to a plurality of electrical signals. A processor processes the plurality of electrical signals to form an image of the target.
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3.发明申请公开(公告)号：US20190384048A1
公开(公告)日：2019-12-19
申请号：US16443760
申请日：2019-06-17
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Pablo A. Valdes , David W. Roberts , Keith D. Paulsen , Frederic Leblond
Abstract: An imaging system includes an illumination device for illuminating a target. A surgical microscope receives light from the target, the surgical microscope comprising at least one optical output port at which at least a portion of the received light is provided as an output from the surgical microscope. A tunable filter receives the portion of the received light provided as the output from the surgical microscope, the tunable filter being tunable to pass a filtered portion of the received light, the filtered portion of the received light having a plurality of wavelengths selected by the tunable filter and provided as output from the tunable filter. A high-resolution, broad-bandwidth electronic camera receives the light of a plurality of wavelengths selected by the tunable filter, the electronic camera converting the light of a plurality of wavelengths selected by the tunable filter to a plurality of electrical signals. A processor processes the plurality of electrical signals to form an image of the target.
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公开(公告)号：US20240377627A1
公开(公告)日：2024-11-14
申请号：US18783802
申请日：2024-07-25
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Pablo A. Valdes , David W. Roberts , Keith D. Paulsen , Frederic Leblond
Abstract: A surgical microscope with a fluorescence excitation illuminator receives fluorescence emissions from a target, the surgical microscope having an optical output port. A tunable filter passes a filtered portion of light from the surgical microscope, the filtered light has wavelengths selected by the tunable filter and is provided to a high-resolution, broad-bandwidth electronic camera. The electronic camera converts light from the tunable filter to electrical signals. A processor processes the electrical signals to form an image of the target including estimated fluorophore depth, the image corrected for optical absorption and scattering parameters of the target. The processor also performs deformation modeling of the target to track tumor position changes during surgery. Embodiments track surface changes of the target using stereo cameras to support the deformation modeling, some images may include information from preoperative CT or MRI, and some images may map biomarkers like HbO2 and DexoHb.
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公开(公告)号：US11656448B2
公开(公告)日：2023-05-23
申请号：US16443760
申请日：2019-06-17
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Pablo A. Valdes , David W. Roberts , Keith D. Paulsen , Frederic Leblond
Abstract: An imaging system includes an illumination device for illuminating a target. A surgical microscope receives light from the target, the surgical microscope comprising at least one optical output port at which at least a portion of the received light is provided as an output from the surgical microscope. A tunable filter receives the portion of the received light provided as the output from the surgical microscope, the tunable filter being tunable to pass a filtered portion of the received light, the filtered portion of the received light having a plurality of wavelengths selected by the tunable filter and provided as output from the tunable filter. A high-resolution, broad-bandwidth electronic camera receives the light of a plurality of wavelengths selected by the tunable filter, the electronic camera converting the light of a plurality of wavelengths selected by the tunable filter to a plurality of electrical signals. A processor processes the plurality of electrical signals to form an image of the target.
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6.发明申请Method And Apparatus For Quantitative Hyperspectral Fluorescence And Reflectance Imaging For Surgical Guidance 审中-公开用于定量高光谱荧光和反射成像的手术指导的方法和装置公开(公告)号：US20140378843A1
公开(公告)日：2014-12-25
申请号：US14373443
申请日：2013-01-18
Applicant: The Trustees of Dartmouth College
Inventor： Pablo A. Valdes , David W. Roberts , Keith D. Paulsent , Frederic Leblond
Abstract: An imaging system includes an illumination device for illuminating a target. A surgical microscope receives light from the target, the surgical microscope comprising at least one optical output port at which at least a portion of the received light is provided as an output from the surgical microscope. A tunable filter receives the portion of the received light provided as the output from the surgical microscope, the tunable filter being tunable to pass a filtered portion of the received light, the filtered portion of the received light having a plurality of wavelengths selected by the tunable filter and provided as output from the tunable filter. A high-resolution, broad-bandwidth electronic camera receives the light of a plurality of wavelengths selected by the tunable filter, the electronic camera converting the light of a plurality of wavelengths selected by the tunable filter to a plurality of electrical signals. A processor processes the plurality of electrical signals to form an image of the target.
Abstract translation: 成像系统包括用于照射目标的照明装置。 手术显微镜从目标物接收光，所述手术显微镜包括至少一个光学输出端口，在所述光学输出端口处，至少一部分所接收的光被提供为来自所述外科显微镜的输出。 可调滤波器接收作为来自外科手术显微镜的输出提供的接收光的一部分，可调谐滤波器可调谐以通过接收光的滤波部分，所接收的光的经滤波部分具有由可调谐器选择的多个波长 过滤器并作为可调滤波器的输出提供。 高分辨率，宽带宽电子照相机接收由可调谐滤波器选择的多个波长的光，电子照相机将由可调谐滤波器选择的多个波长的光转换为多个电信号。 处理器处理多个电信号以形成目标的图像。
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