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公开(公告)号：US11931116B2
公开(公告)日：2024-03-19
申请号：US17872606
申请日：2022-07-25
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Venkataramanan Krishnaswamy , Richard J. Barth, Jr. , Keith D. Paulsen
IPC: G06K9/00 , A61B34/00 , A61B34/10 , A61B34/20 , A61B90/00 , G06T7/00 , G06T7/33 , A61B17/00 , A61B17/34
CPC classification number: A61B34/20 , A61B34/10 , A61B34/25 , A61B90/361 , G06T7/0012 , G06T7/33 , A61B2017/008 , A61B2017/3405 , A61B2034/105 , A61B2034/107 , A61B2034/2065 , A61B2090/365 , A61B2090/378 , A61B2090/3908 , A61B2090/395 , G06T2207/30068
Abstract: A method for guiding resection of local tissue from a patient includes generating at least one image of the patient, automatically determining a plurality of surgical guidance cues indicating three-dimensional spatial properties associated with the local tissue, and generating a visualization of the surgical guidance cues relative to the surface. A system for generating surgical guidance cues for resection of a local tissue from a patient includes a location module for processing at least one image of the patient to determine three-dimensional spatial properties of the local tissue, and a surgical cue generator for generating the surgical guidance cues based upon the three-dimensional spatial properties. A patient-specific locator form for guiding resection of local tissue from a patient includes a locator form surface matching surface of the patient, and a plurality of features indicating a plurality of surgical guidance cues, respectively.
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公开(公告)号：US11690558B2
公开(公告)日：2023-07-04
申请号：US17486839
申请日：2021-09-27
Applicant: The Trustees of Dartmouth College
Inventor： David W. Roberts , Keith D. Paulsen , Alexander Hartov , Songbai Ji , Xiaoyao Fan
IPC: A61B5/00 , G06T7/33 , A61B34/10 , A61B5/377 , G06T3/00 , H04N13/257 , H04N13/239 , A61B90/00 , A61B5/055 , A61B5/369
CPC classification number: A61B5/377 , A61B5/0042 , A61B5/0077 , G06T3/0068 , G06T7/33 , H04N13/239 , H04N13/257 , A61B5/055 , A61B5/369 , A61B2034/104 , A61B2034/105 , A61B2034/107 , A61B2090/367 , G06T2207/10012 , G06T2207/10064 , G06T2207/10072 , G06T2207/30016
Abstract: A surgical guidance system has two cameras to provide stereo image stream of a surgical field; and a stereo viewer. The system has a 3D surface extraction module that generates a first 3D model of the surgical field from the stereo image streams; a registration module for co-registering annotating data with the first 3D model; and a stereo image enhancer for graphically overlaying at least part of the annotating data onto the stereo image stream to form an enhanced stereo image stream for display, where the enhanced stereo stream enhances a surgeon's perception of the surgical field. The registration module has an alignment refiner to adjust registration of the annotating data with the 3D model based upon matching of features within the 3D model and features within the annotating data; and in an embodiment, a deformation modeler to deform the annotating data based upon a determined tissue deformation.
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公开(公告)号：US11564639B2
公开(公告)日：2023-01-31
申请号：US14767836
申请日：2014-02-13
Applicant: The Trustees of Dartmouth College
Inventor： Kenneth Tichauer , Robert W. Holt , Frederic Leblond , Pablo Valdes , Brian W. Pogue , Keith D. Paulsen , David W. Roberts
Abstract: A method of generating corrected fluorescence data of concentrations of a targeted fluorophore in tissue of a subject includes administering first and second fluorescent contrast agents to the subject, the first contrast agent targeted to tissue of interest, the second agent untargeted. The tissue is illuminated with light of a first stimulus wavelength and first data is acquired at an appropriate emissions wavelength; the tissue is illuminated at a second stimulus wavelength and second data is acquired at a second emissions wavelength associated with the second agent, the first and second emissions wavelength differ. Difference data is generated by subtracting the second data from the first data. A system provides for stimulus and capture at multiple wavelengths, with image storage memory and subtraction code, to perform the method. Corrected data may form an fluorescence image, or is used to generate fluorescence tomographic images.
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公开(公告)号：US11129562B2
公开(公告)日：2021-09-28
申请号：US16785882
申请日：2020-02-10
Applicant: The Trustees of Dartmouth College
Inventor： David W. Roberts , Keith D. Paulsen , Alexander Hartov , Songbai Ji , Xiaoyao Fan
IPC: H04N13/239 , A61B34/10 , A61B5/055 , A61B5/377 , G06T3/00 , H04N13/257 , A61B5/00 , G06T7/33 , A61B90/00 , A61B5/369
Abstract: A surgical guidance system has two cameras to provide stereo image stream of a surgical field; and a stereo viewer. The system has a 3D surface extraction module that generates a first 3D model of the surgical field from the stereo image streams; a registration module for co-registering annotating data with the first 3D model; and a stereo image enhancer for graphically overlaying at least part of the annotating data onto the stereo image stream to form an enhanced stereo image stream for display, where the enhanced stereo stream enhances a surgeon's perception of the surgical field. The registration module has an alignment refiner to adjust registration of the annotating data with the 3D model based upon matching of features within the 3D model and features within the annotating data; and in an embodiment, a deformation modeler to deform the annotating data based upon a determined tissue deformation.
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公开(公告)号：US11099401B2
公开(公告)日：2021-08-24
申请号：US16443519
申请日：2019-06-17
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Jonathan D. Olson , Keith D. Paulsen , David W. Roberts
Abstract: A birefringent spectral demultiplexer for hyperspectral imaging includes N birefringent beamsplitting stages arranged along a light propagation path, to produce 2N mutually divergent output light beams. Each of the output light beams differs from every other one of the output light beams in polarization and/or spectral bandwidth. Each birefringent beamsplitting stage includes a retarder for modifying polarization of each light beam received by the birefringent beamsplitting stage, and a Wollaston prism for splitting each light beam into two orthogonally polarized and divergent light beams. The Wollaston prism has a beamsplitting interface arranged at an oblique angle to the light propagation path. The oblique angle of the beamsplitting interface of each Wollaston prism of the series, except for the first one, is smaller than the oblique angle of the beamsplitting interface of each preceding Wollaston prism. The demultiplexer may be configured to accept input light of any polarization.
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Patent Agency Ranking
6.发明申请公开(公告)号：US20210239617A1
公开(公告)日：2021-08-05
申请号：US17050745
申请日：2019-04-26
Inventor： Keith D. Paulsen , David W. Roberts , Dennis Wirth , Brian C. Wilson , Mira Sibai
IPC: G01N21/64 , G01N33/483 , G01B11/22 , G01N21/47
Abstract: A method and device for determining the depth and fluorophore concentration of a fluorophore concentration below the surface of an optically absorbing and scattering medium suitable for use in fluorescence-based surgical guidance such as in tumor resection is described. Long-wavelength stimulus light us used to obtain deep tissue penetration. Recovery of depth is performed by fitting measured modulation amplitudes for each spatial frequency to precomputed modulation amplitudes in a table of modulation amplitudes indexed by optical parameters and depth.
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公开(公告)号：US11937951B2
公开(公告)日：2024-03-26
申请号：US18159495
申请日：2023-01-25
Applicant: The Trustees of Dartmouth College
Inventor： Kenneth Tichauer , Robert W. Holt , Frederic Leblond , Pablo Valdes , Brian W. Pogue , Keith D. Paulsen , David W. Roberts
CPC classification number: A61B5/7278 , A61B5/0071 , A61K49/0058 , A61B5/0035 , A61B5/0062 , A61B2576/00
Abstract: A method of generating corrected fluorescence data of concentrations of a targeted fluorophore in tissue of a subject includes administering first and second fluorescent contrast agents to the subject, the first contrast agent targeted to tissue of interest, the second agent untargeted. The tissue is illuminated with light of a first stimulus wavelength and first data is acquired at an appropriate emissions wavelength; the tissue is illuminated at a second stimulus wavelength and second data is acquired at a second emissions wavelength associated with the second agent, the first and second emissions wavelength differ. Difference data is generated by subtracting the second data from the first data. A system provides for stimulus and capture at multiple wavelengths, with image storage memory and subtraction code, to perform the method. Corrected data may form an fluorescence image, or is used to generate fluorescence tomographic images.
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8.发明公开公开(公告)号：US20230280577A1
公开(公告)日：2023-09-07
申请号：US18144767
申请日：2023-05-08
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Pablo A. Valdes , David W. Roberts , Keith D. Paulsen , Frederic Leblond
Abstract: An imaging system includes an illumination device for illuminating a target. A surgical microscope receives light from the target, the surgical microscope comprising at least one optical output port at which at least a portion of the received light is provided as an output from the surgical microscope. A tunable filter receives the portion of the received light provided as the output from the surgical microscope, the tunable filter being tunable to pass a filtered portion of the received light, the filtered portion of the received light having a plurality of wavelengths selected by the tunable filter and provided as output from the tunable filter. A high-resolution, broad-bandwidth electronic camera receives the light of a plurality of wavelengths selected by the tunable filter, the electronic camera converting the light of a plurality of wavelengths selected by the tunable filter to a plurality of electrical signals. A processor processes the plurality of electrical signals to form an image of the target.
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公开(公告)号：US20230233157A1
公开(公告)日：2023-07-27
申请号：US18159495
申请日：2023-01-25
Applicant: The Trustees of Dartmouth College
Inventor： Kenneth Tichauer , Robert W. Holt , Frederic Leblond , Pablo Valdes , Brian W. Pogue , Keith D. Paulsen , David W. Roberts
CPC classification number: A61B5/7278 , A61B5/0071 , A61K49/0058 , A61B5/0062 , A61B5/0035 , A61B2576/00
Abstract: A method of generating corrected fluorescence data of concentrations of a targeted fluorophore in tissue of a subject includes administering first and second fluorescent contrast agents to the subject, the first contrast agent targeted to tissue of interest, the second agent untargeted. The tissue is illuminated with light of a first stimulus wavelength and first data is acquired at an appropriate emissions wavelength; the tissue is illuminated at a second stimulus wavelength and second data is acquired at a second emissions wavelength associated with the second agent, the first and second emissions wavelength differ. Difference data is generated by subtracting the second data from the first data. A system provides for stimulus and capture at multiple wavelengths, with image storage memory and subtraction code, to perform the method. Corrected data may form an fluorescence image, or is used to generate fluorescence tomographic images.
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10.发明授权公开(公告)号：US11662315B2
公开(公告)日：2023-05-30
申请号：US17516490
申请日：2021-11-01
Inventor： Keith D. Paulsen , David W. Roberts , Dennis Wirth , Brian C. Wilson , Mira Sibai
IPC: G01B11/22 , G01N21/64 , G01N21/47 , G01N33/483
CPC classification number: G01N21/6456 , G01B11/22 , G01N21/4795 , G01N33/4833 , G01N2201/062
Abstract: A method and device for determining the depth and fluorophore concentration of a fluorophore concentration below the surface of an optically absorbing and scattering medium suitable for use in fluorescence-based surgical guidance such as in tumor resection is described. Long-wavelength stimulus light us used to obtain deep tissue penetration. Recovery of depth is performed by fitting measured modulation amplitudes for each spatial frequency to precomputed modulation amplitudes in a table of modulation amplitudes indexed by optical parameters and depth.
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