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    METHOD AND APPARATUS FOR QUANTITATIVE HYPERSPECTRAL FLUORESCENCE AND REFLECTANCE IMAGING FOR SURGICAL GUIDANCE
    2.
    发明公开
    METHOD AND APPARATUS FOR QUANTITATIVE HYPERSPECTRAL FLUORESCENCE AND REFLECTANCE IMAGING FOR SURGICAL GUIDANCE 审中-公开

    公开(公告)号：US20230280577A1

    公开(公告)日：2023-09-07

    申请号：US18144767

    申请日：2023-05-08

    Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

    Inventor： Pablo A. Valdes ,  David W. Roberts ,  Keith D. Paulsen ,  Frederic Leblond

    IPC: G02B21/06 ,  G02B21/36 ,  A61B1/06

    CPC classification number: G02B21/06 ,  G02B21/36 ,  A61B1/063

    Abstract: An imaging system includes an illumination device for illuminating a target. A surgical microscope receives light from the target, the surgical microscope comprising at least one optical output port at which at least a portion of the received light is provided as an output from the surgical microscope. A tunable filter receives the portion of the received light provided as the output from the surgical microscope, the tunable filter being tunable to pass a filtered portion of the received light, the filtered portion of the received light having a plurality of wavelengths selected by the tunable filter and provided as output from the tunable filter. A high-resolution, broad-bandwidth electronic camera receives the light of a plurality of wavelengths selected by the tunable filter, the electronic camera converting the light of a plurality of wavelengths selected by the tunable filter to a plurality of electrical signals. A processor processes the plurality of electrical signals to form an image of the target.

    Method and apparatus for medical imaging using differencing of multiple fluorophores
    7.
    发明授权
    Method and apparatus for medical imaging using differencing of multiple fluorophores 有权

    公开(公告)号：US11564639B2

    公开(公告)日：2023-01-31

    申请号：US14767836

    申请日：2014-02-13

    Applicant: The Trustees of Dartmouth College

    Inventor： Kenneth Tichauer ,  Robert W. Holt ,  Frederic Leblond ,  Pablo Valdes ,  Brian W. Pogue ,  Keith D. Paulsen ,  David W. Roberts

    IPC: A61B5/00 ,  A61K49/00

    Abstract: A method of generating corrected fluorescence data of concentrations of a targeted fluorophore in tissue of a subject includes administering first and second fluorescent contrast agents to the subject, the first contrast agent targeted to tissue of interest, the second agent untargeted. The tissue is illuminated with light of a first stimulus wavelength and first data is acquired at an appropriate emissions wavelength; the tissue is illuminated at a second stimulus wavelength and second data is acquired at a second emissions wavelength associated with the second agent, the first and second emissions wavelength differ. Difference data is generated by subtracting the second data from the first data. A system provides for stimulus and capture at multiple wavelengths, with image storage memory and subtraction code, to perform the method. Corrected data may form an fluorescence image, or is used to generate fluorescence tomographic images.

    Birefringent spectral demultiplexer for hyperspectral imaging
    9.
    发明授权
    Birefringent spectral demultiplexer for hyperspectral imaging 有权

    公开(公告)号：US11099401B2

    公开(公告)日：2021-08-24

    申请号：US16443519

    申请日：2019-06-17

    Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

    Inventor： Jonathan D. Olson ,  Keith D. Paulsen ,  David W. Roberts

    IPC: G02B27/28 ,  G02B5/20 ,  H04N5/225 ,  H04N5/33 ,  G02B27/42

    Abstract: A birefringent spectral demultiplexer for hyperspectral imaging includes N birefringent beamsplitting stages arranged along a light propagation path, to produce 2N mutually divergent output light beams. Each of the output light beams differs from every other one of the output light beams in polarization and/or spectral bandwidth. Each birefringent beamsplitting stage includes a retarder for modifying polarization of each light beam received by the birefringent beamsplitting stage, and a Wollaston prism for splitting each light beam into two orthogonally polarized and divergent light beams. The Wollaston prism has a beamsplitting interface arranged at an oblique angle to the light propagation path. The oblique angle of the beamsplitting interface of each Wollaston prism of the series, except for the first one, is smaller than the oblique angle of the beamsplitting interface of each preceding Wollaston prism. The demultiplexer may be configured to accept input light of any polarization.

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