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公开(公告)号：US11564639B2
公开(公告)日：2023-01-31
申请号：US14767836
申请日：2014-02-13
Applicant: The Trustees of Dartmouth College
Inventor： Kenneth Tichauer , Robert W. Holt , Frederic Leblond , Pablo Valdes , Brian W. Pogue , Keith D. Paulsen , David W. Roberts
Abstract: A method of generating corrected fluorescence data of concentrations of a targeted fluorophore in tissue of a subject includes administering first and second fluorescent contrast agents to the subject, the first contrast agent targeted to tissue of interest, the second agent untargeted. The tissue is illuminated with light of a first stimulus wavelength and first data is acquired at an appropriate emissions wavelength; the tissue is illuminated at a second stimulus wavelength and second data is acquired at a second emissions wavelength associated with the second agent, the first and second emissions wavelength differ. Difference data is generated by subtracting the second data from the first data. A system provides for stimulus and capture at multiple wavelengths, with image storage memory and subtraction code, to perform the method. Corrected data may form an fluorescence image, or is used to generate fluorescence tomographic images.
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公开(公告)号：US20240377627A1
公开(公告)日：2024-11-14
申请号：US18783802
申请日：2024-07-25
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Pablo A. Valdes , David W. Roberts , Keith D. Paulsen , Frederic Leblond
Abstract: A surgical microscope with a fluorescence excitation illuminator receives fluorescence emissions from a target, the surgical microscope having an optical output port. A tunable filter passes a filtered portion of light from the surgical microscope, the filtered light has wavelengths selected by the tunable filter and is provided to a high-resolution, broad-bandwidth electronic camera. The electronic camera converts light from the tunable filter to electrical signals. A processor processes the electrical signals to form an image of the target including estimated fluorophore depth, the image corrected for optical absorption and scattering parameters of the target. The processor also performs deformation modeling of the target to track tumor position changes during surgery. Embodiments track surface changes of the target using stereo cameras to support the deformation modeling, some images may include information from preoperative CT or MRI, and some images may map biomarkers like HbO2 and DexoHb.
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公开(公告)号：US20240148291A1
公开(公告)日：2024-05-09
申请号：US18401664
申请日：2024-01-01
Applicant: The Trustees of Dartmouth College
Inventor： Pablo Valdes , Frederic Leblond , Keith D. Paulsen , Brian Campbell Wilson , David W. Roberts , Michael Jermyn
IPC: A61B5/1455 , A61B1/00 , A61B1/04 , A61B1/05 , A61B1/06 , A61B1/07 , A61B5/00 , A61B5/055 , A61B5/145 , A61B5/1459 , A61B5/1495 , G01J3/02 , G01J3/12 , G01J3/28
CPC classification number: A61B5/14556 , A61B1/00009 , A61B1/000094 , A61B1/00165 , A61B1/00193 , A61B1/00194 , A61B1/042 , A61B1/043 , A61B1/05 , A61B1/0646 , A61B1/0669 , A61B1/0684 , A61B1/07 , A61B5/0071 , A61B5/0077 , A61B5/055 , A61B5/14546 , A61B5/14553 , A61B5/1459 , A61B5/1495 , A61B5/7264 , G01J3/0229 , G01J3/1256 , G01J3/2823 , A61B1/3132
Abstract: An imaging system, such as a surgical microscope, laparoscope, or endoscope or integrated with these devices, includes an illuminator providing patterned white light and/or fluorescent stimulus light. The system receives and images light hyperspectrally, in embodiments using a hyperspectral imaging array, and/or using narrowband tunable filters for passing filtered received light to an imager. Embodiments may construct a 3-D surface model from stereo images, and will estimate optical properties of the target using images taken in patterned light or using other approximations obtained from white light exposures. Hyperspectral images taken under stimulus light are displayed as fluorescent images, and corrected for optical properties of tissue to provide quantitative maps of fluorophore concentration. Spectral information from hyperspectral images is processed to provide depth of fluorophore below the tissue surface. Quantitative images of fluorescence at depth are also prepared. The images are displayed to a surgeon for use in surgery.
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公开(公告)号：US11857317B2
公开(公告)日：2024-01-02
申请号：US17961480
申请日：2022-10-06
Applicant: The Trustees of Dartmouth College
Inventor： Pablo Valdes , Frederic Leblond , Keith D. Paulsen , Brian Campbell Wilson , David W. Roberts , Michael Jermyn
IPC: A61B5/1455 , A61B5/1459 , A61B1/04 , A61B5/145 , A61B5/00 , A61B5/1495 , A61B1/06 , A61B5/055 , G01J3/28 , A61B1/05 , G01J3/12 , G01J3/02 , A61B1/00 , A61B1/07 , A61B1/313
CPC classification number: A61B5/14556 , A61B1/00009 , A61B1/000094 , A61B1/00165 , A61B1/00193 , A61B1/00194 , A61B1/042 , A61B1/043 , A61B1/05 , A61B1/0646 , A61B1/0669 , A61B1/0684 , A61B1/07 , A61B5/0071 , A61B5/0077 , A61B5/055 , A61B5/1459 , A61B5/1495 , A61B5/14546 , A61B5/14553 , A61B5/7264 , G01J3/0229 , G01J3/1256 , G01J3/2823 , A61B1/3132 , G01J2003/1269 , G01J2003/2826
Abstract: An imaging system, such as a surgical microscope, laparoscope, or endoscope or integrated with these devices, includes an illuminator providing patterned white light and/or fluorescent stimulus light. The system receives and images light hyperspectrally, in embodiments using a hyperspectral imaging array, and/or using narrowband tunable filters for passing filtered received light to an imager. Embodiments may construct a 3-D surface model from stereo images, and will estimate optical properties of the target using images taken in patterned light or using other approximations obtained from white light exposures. Hyperspectral images taken under stimulus light are displayed as fluorescent images, and corrected for optical properties of tissue to provide quantitative maps of fluorophore concentration. Spectral information from hyperspectral images is processed to provide depth of fluorophore below the tissue surface. Quantitative images of fluorescence at depth are also prepared. The images are displayed to a surgeon for use in surgery.
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公开(公告)号：US11656448B2
公开(公告)日：2023-05-23
申请号：US16443760
申请日：2019-06-17
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Pablo A. Valdes , David W. Roberts , Keith D. Paulsen , Frederic Leblond
Abstract: An imaging system includes an illumination device for illuminating a target. A surgical microscope receives light from the target, the surgical microscope comprising at least one optical output port at which at least a portion of the received light is provided as an output from the surgical microscope. A tunable filter receives the portion of the received light provided as the output from the surgical microscope, the tunable filter being tunable to pass a filtered portion of the received light, the filtered portion of the received light having a plurality of wavelengths selected by the tunable filter and provided as output from the tunable filter. A high-resolution, broad-bandwidth electronic camera receives the light of a plurality of wavelengths selected by the tunable filter, the electronic camera converting the light of a plurality of wavelengths selected by the tunable filter to a plurality of electrical signals. A processor processes the plurality of electrical signals to form an image of the target.
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Patent Agency Ranking
公开(公告)号：US11510600B2
公开(公告)日：2022-11-29
申请号：US15044097
申请日：2016-02-15
Applicant: The Trustees of Dartmouth College
Inventor： Pablo Valdes , Frederic Leblond , Keith D. Paulsen , Brian Campbell Wilson , David W. Roberts , Michael Jermyn
IPC: A61B5/1455 , A61B5/1459 , A61B1/04 , A61B5/145 , A61B5/00 , A61B5/1495 , A61B1/06 , A61B1/00 , A61B5/055 , G01J3/28 , A61B1/05 , G01J3/12 , G01J3/02 , A61B1/07 , A61B1/313
Abstract: An imaging system, such as a surgical microscope, laparoscope, or endoscope or integrated with these devices, includes an illuminator providing patterned white light and/or fluorescent stimulus light. The system receives and images light hyperspectrally, in embodiments using a hyperspectral imaging array, and/or using narrowband tunable filters for passing filtered received light to an imager. Embodiments may construct a 3-D surface model from stereo images, and will estimate optical properties of the target using images taken in patterned light or using other approximations obtained from white light exposures. Hyperspectral images taken under stimulus light are displayed as fluorescent images, and corrected for optical properties of tissue to provide quantitative maps of fluorophore concentration. Spectral information from hyperspectral images is processed to provide depth of fluorophore below the tissue surface. Quantitative images of fluorescence at depth are also prepared. The images are displayed to a surgeon for use in surgery.
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7.发明申请Method And Apparatus For Quantitative Hyperspectral Fluorescence And Reflectance Imaging For Surgical Guidance 审中-公开用于定量高光谱荧光和反射成像的手术指导的方法和装置公开(公告)号：US20140378843A1
公开(公告)日：2014-12-25
申请号：US14373443
申请日：2013-01-18
Applicant: The Trustees of Dartmouth College
Inventor： Pablo A. Valdes , David W. Roberts , Keith D. Paulsent , Frederic Leblond
Abstract: An imaging system includes an illumination device for illuminating a target. A surgical microscope receives light from the target, the surgical microscope comprising at least one optical output port at which at least a portion of the received light is provided as an output from the surgical microscope. A tunable filter receives the portion of the received light provided as the output from the surgical microscope, the tunable filter being tunable to pass a filtered portion of the received light, the filtered portion of the received light having a plurality of wavelengths selected by the tunable filter and provided as output from the tunable filter. A high-resolution, broad-bandwidth electronic camera receives the light of a plurality of wavelengths selected by the tunable filter, the electronic camera converting the light of a plurality of wavelengths selected by the tunable filter to a plurality of electrical signals. A processor processes the plurality of electrical signals to form an image of the target.
Abstract translation: 成像系统包括用于照射目标的照明装置。 手术显微镜从目标物接收光，所述手术显微镜包括至少一个光学输出端口，在所述光学输出端口处，至少一部分所接收的光被提供为来自所述外科显微镜的输出。 可调滤波器接收作为来自外科手术显微镜的输出提供的接收光的一部分，可调谐滤波器可调谐以通过接收光的滤波部分，所接收的光的经滤波部分具有由可调谐器选择的多个波长 过滤器并作为可调滤波器的输出提供。 高分辨率，宽带宽电子照相机接收由可调谐滤波器选择的多个波长的光，电子照相机将由可调谐滤波器选择的多个波长的光转换为多个电信号。 处理器处理多个电信号以形成目标的图像。
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公开(公告)号：US12285277B2
公开(公告)日：2025-04-29
申请号：US18614944
申请日：2024-03-25
Applicant: The Trustees of Dartmouth College
Inventor： Kenneth Tichauer , Robert W. Holt , Frederic Leblond , Pablo Valdes , Brian W. Pogue , Keith D. Paulsen , David W. Roberts
Abstract: A method of generating corrected fluorescence data of concentrations of a targeted fluorophore in tissue of a subject includes administering first and second fluorescent contrast agents to the subject, the first contrast agent targeted to tissue of interest, the second agent untargeted. The tissue is illuminated with light of a first stimulus wavelength and first data is acquired at an appropriate emissions wavelength; the tissue is illuminated at a second stimulus wavelength and second data is acquired at a second emissions wavelength associated with the second agent, the first and second emissions wavelength differ. Difference data is generated by subtracting the second data from the first data. A system provides for stimulus and capture at multiple wavelengths, with image storage memory and subtraction code, to perform the method. Corrected data may form an fluorescence image, or is used to generate fluorescence tomographic images.
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公开(公告)号：US20240260909A1
公开(公告)日：2024-08-08
申请号：US18614944
申请日：2024-03-25
Applicant: The Trustees of Dartmouth College
Inventor： Kenneth Tichauer , Robert W. Holt , Frederic Leblond , Pablo Valdes , Brian W. Pogue , Keith D. Paulsen , David W. Roberts
CPC classification number: A61B5/7278 , A61B5/0071 , A61K49/0058 , A61B5/0035 , A61B5/0062 , A61B2576/00
Abstract: A method of generating corrected fluorescence data of concentrations of a targeted fluorophore in tissue of a subject includes administering first and second fluorescent contrast agents to the subject, the first contrast agent targeted to tissue of interest, the second agent untargeted. The tissue is illuminated with light of a first stimulus wavelength and first data is acquired at an appropriate emissions wavelength; the tissue is illuminated at a second stimulus wavelength and second data is acquired at a second emissions wavelength associated with the second agent, the first and second emissions wavelength differ. Difference data is generated by subtracting the second data from the first data. A system provides for stimulus and capture at multiple wavelengths, with image storage memory and subtraction code, to perform the method. Corrected data may form an fluorescence image, or is used to generate fluorescence tomographic images.
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公开(公告)号：US20230075997A1
公开(公告)日：2023-03-09
申请号：US17961480
申请日：2022-10-06
Applicant: The Trustees of Dartmouth College
Inventor： Pablo Valdes , Frederic Leblond , Keith D. Paulsen , Brian Campbell Wilson , David W. Roberts , Michael Jermyn
IPC: A61B5/1455 , A61B5/1459 , A61B1/04 , A61B5/145 , A61B5/00 , A61B5/1495 , A61B1/06 , A61B5/055 , G01J3/28 , A61B1/05 , G01J3/12 , G01J3/02 , A61B1/00 , A61B1/07
Abstract: An imaging system, such as a surgical microscope, laparoscope, or endoscope or integrated with these devices, includes an illuminator providing patterned white light and/or fluorescent stimulus light. The system receives and images light hyperspectrally, in embodiments using a hyperspectral imaging array, and/or using narrowband tunable filters for passing filtered received light to an imager. Embodiments may construct a 3-D surface model from stereo images, and will estimate optical properties of the target using images taken in patterned light or using other approximations obtained from white light exposures. Hyperspectral images taken under stimulus light are displayed as fluorescent images, and corrected for optical properties of tissue to provide quantitative maps of fluorophore concentration. Spectral information from hyperspectral images is processed to provide depth of fluorophore below the tissue surface. Quantitative images of fluorescence at depth are also prepared. The images are displayed to a surgeon for use in surgery.
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