-
公开(公告)号：US10662238B2
公开(公告)日：2020-05-26
申请号：US15982998
申请日：2018-05-17
申请人： THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services , INSTITUTO NACIONAL DE TECNOLOGIA AGROPECUARIA
发明人： Karin Bok , Lorena Laura Garaicoechea , Viviana Parreno , Andrea Pamela Aguilar , Marina Bok , Lisbeth Kim Green , Stanislav Vladimirovich Sosnovtsev
IPC分类号： C07K16/10 , G01N33/569 , A61K33/44 , A61K39/00
摘要： Isolated VHH monoclonal antibodies are disclosed that specifically bind to a Norovirus polypeptide. In some embodiments, the Norovirus is a Genogroup I Norovirus or a Genogroup II Norovirus. In other embodiments, the Norovirus is Norwalk or MD2004 virus. In some embodiments, the monoclonal antibodies specifically bind VP1. Also disclosed are compositions including the disclosed antibodies, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of a Norovirus in a biological sample, or detecting a Norovirus infection. Also disclosed are methods of treating and/or preventing a NoV infection.
-
公开(公告)号：US11325965B2
公开(公告)日：2022-05-10
申请号：US16854703
申请日：2020-04-21
申请人： THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services , INSTITUTO NACIONAL DE TECNOLOGIA AGROPECUARIA
发明人： Karin Bok , Lorena Laura Garaicoechea , Viviana Parreno , Andrea Pamela Aguilar , Marina Bok , Lisbeth Kim Green , Stanislav Vladimirovich Sosnovtsev
IPC分类号： G01N33/569 , C07K16/10 , A61K39/00
摘要： Isolated VHH monoclonal antibodies are disclosed that specifically bind to a Norovirus polypeptide. In some embodiments, the Norovirus is a Genogroup I Norovirus or a Genogroup II Norovirus. In other embodiments, the Norovirus is Norwalk or MD2004 virus. In some embodiments, the monoclonal antibodies specifically bind VP1. Also disclosed are compositions including the disclosed antibodies, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of a Norovirus in a biological sample, or detecting a Norovirus infection. Also disclosed are methods of treating and/or preventing a NoV infection.
-
公开(公告)号：US09815887B2
公开(公告)日：2017-11-14
申请号：US15359438
申请日：2016-11-22
IPC分类号： C07K16/10 , A61K39/42 , A61K45/06 , G01N33/569 , A61K39/00
CPC分类号： C07K16/10 , A61K39/42 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N33/56983 , G01N2333/08 , G01N2469/10
摘要： Monoclonal neutralizing antibodies are disclosed that specifically bind to a Norovirus. In some embodiments, the Norovirus is a genogroup II Norovirus or a Genogroup II Norovirus. In some embodiments, the Norovirus is Nowalk virus. In some embodiments, the monoclonal antibodies specifically bind VP1. Also disclosed are compositions including the disclosed antibodies, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of a Norovirus in a biological sample, or detecting a Norovirus infection. In addition, the neutralization ability of the disclosed antibodies makes them ideal for treating a subject with a Norovirus infection. Thus, disclosed are methods of treating and/or preventing these infections.
-
公开(公告)号：US09534041B2
公开(公告)日：2017-01-03
申请号：US14767274
申请日：2014-02-11
IPC分类号： C07K16/10 , A61K45/06 , A61K39/42 , G01N33/569 , A61K39/00
CPC分类号： C07K16/10 , A61K39/42 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N33/56983 , G01N2333/08 , G01N2469/10
摘要： Monoclonal neutralizing antibodies are disclosed that specifically bind to a Norovirus. In some embodiments, the Norovirus is a genogroup II Norovirus or a Genogroup II Norovirus. In some embodiments, the Norovirus is Norwalk virus. In some embodiments, the monoclonal antibodies specifically bind VP1. Also disclosed are compositions including the disclosed antibodies, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of a Norovirus in a biological sample, or detecting a Norovirus infection. In addition, the neutralization ability of the disclosed antibodies makes them ideal for treating a subject with a Norovirus infection. Thus, disclosed are methods of treating and/or preventing these infections.
摘要翻译： 公开了特异性结合诺如病毒的单克隆中和抗体。 在一些实施方案中，诺如病毒是基因组II诺如病毒或Genogroup II诺如病毒。 在一些实施方案中，诺如病毒是诺瓦克病毒。 在一些实施方案中，单克隆抗体特异性结合VP1。 还公开了包括所公开的抗体，编码这些抗体的核酸，包括核酸的表达载体和表达核酸的分离的宿主细胞的组合物。 本文公开的抗体和组合物可用于检测生物样品中诺如病毒的存在或检测诺如病毒感染。 此外，所公开的抗体的中和能力使其成为用诺如病毒感染治疗受试者的理想选择。 因此，公开了治疗和/或预防这些感染的方法。
-
公开(公告)号：US20180251527A1
公开(公告)日：2018-09-06
申请号：US15982998
申请日：2018-05-17
申请人： THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Serv , INSTITUTO NACIONAL DE TECNOLOGIA AGROPECUARIA
发明人： Karin Bok , Lorena Laura Garaicoechea , Viviana Parreno , Andrea Pamela Aguilar , Marina Bok , Lisbeth Kim Green , Stanislav Vladimirovich Sosnovtsev
IPC分类号： C07K16/10 , G01N33/569 , A61K39/00
摘要： Isolated VHH monoclonal antibodies are disclosed that specifically bind to a Norovirus polypeptide. In some embodiments, the Norovirus is a Genogroup I Norovirus or a Genogroup II Norovirus. In other embodiments, the Norovirus is Norwalk or MD2004 virus. In some embodiments, the monoclonal antibodies specifically bind VP1. Also disclosed are compositions including the disclosed antibodies, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of a Norovirus in a biological sample, or detecting a Norovirus infection. Also disclosed are methods of treating and/or preventing a NoV infection.
-
6.发明申请SINGLE-DOMAIN VHH ANTIBODIES DIRECTED TO NOROVIRUS GI.1 AND GII.4 AND THEIR USE 有权针对NOROVIRUS GI.1和GII.4的单个VHH抗体及其使用公开(公告)号：US20160102136A1
公开(公告)日：2016-04-14
申请号：US14889774
申请日：2014-05-09
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES , INSTITUTO NACIONAL DE TECNOLOGIA AGROPECUARIA
发明人： Karin Bok , Lorena Laura Garaicoechea , Viviana Parreno , Andrea Pamela Aguilar , Marina Bok , Lisbeth Kim Green , Stanislav Vladimirovich Sosnovtsev
IPC分类号： C07K16/10 , G01N33/569
CPC分类号： C07K16/10 , A61K2039/505 , C07K2317/22 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/569 , C07K2317/76 , C07K2317/92 , C12N2770/16011 , C12N2770/16034 , G01N33/56983 , G01N2333/08
摘要： Isolated VHH monoclonal antibodies are disclosed that specifically bind to a Norovirus polypeptide. In some embodiments, the Norovirus is a Genogroup I Norovirus or a Genogroup II Norovirus. In other embodiments, the Norovirus is Norwalk or MD2004 virus. In some embodiments, the monoclonal antibodies specifically bind VP1. Also disclosed are compositions including the disclosed antibodies, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of a Norovirus in a biological sample, or detecting a Norovirus infection. Also disclosed are methods of treating and/or preventing a NoV infection.
摘要翻译： 公开了特异性结合诺如病毒多肽的分离的VHH单克隆抗体。 在一些实施方案中，诺如病毒是Genogroup I诺如病毒或Genogroup II诺如病毒。 在其他实施方案中，诺如病毒是Norwalk或MD2004病毒。 在一些实施方案中，单克隆抗体特异性结合VP1。 还公开了包括所公开的抗体，编码这些抗体的核酸，包括核酸的表达载体和表达核酸的分离的宿主细胞的组合物。 本文公开的抗体和组合物可用于检测生物样品中诺如病毒的存在或检测诺如病毒感染。 还公开了治疗和/或预防NoV感染的方法。
-
公开(公告)号：US20200283507A1
公开(公告)日：2020-09-10
申请号：US16854703
申请日：2020-04-21
申请人： THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Servic , INSTITUTO NACIONAL DE TECNOLOGIA AGROPECUARIA
发明人： Karin Bok , Lorena Laura Garaicoechea , Viviana Parreno , Andrea Pamela Aguilar , Marina Bok , Lisbeth Kim Green , Stanislav Vladimirovich Sosnovtsev
IPC分类号： C07K16/10 , G01N33/569
摘要： Isolated VHH monoclonal antibodies are disclosed that specifically bind to a Norovirus polypeptide. In some embodiments, the Norovirus is a Genogroup I Norovirus or a Genogroup II Norovirus. In other embodiments, the Norovirus is Norwalk or MD2004 virus. In some embodiments, the monoclonal antibodies specifically bind VP1. Also disclosed are compositions including the disclosed antibodies, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of a Norovirus in a biological sample, or detecting a Norovirus infection. Also disclosed are methods of treating and/or preventing a NoV infection.
-
公开(公告)号：US10000556B2
公开(公告)日：2018-06-19
申请号：US14889774
申请日：2014-05-09
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPART OF HEALTH AND HUMAN SERVICES , INSTITUTO NACIONAL DE TECNOLOGIA AGROPECUARIA
发明人： Karin Bok , Lorena Laura Garaicoechea , Viviana Parreno , Andrea Pamela Aguilar , Marina Bok , Lisbeth Kim Green , Stanislav Vladimirovich Sosnovtsev
IPC分类号： C07K16/10 , G01N33/569 , A61K39/00
CPC分类号： C07K16/10 , A61K2039/505 , C07K2317/22 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/569 , C07K2317/76 , C07K2317/92 , C12N2770/16011 , C12N2770/16034 , G01N33/56983 , G01N2333/08
摘要： Isolated VHH monoclonal antibodies are disclosed that specifically bind to a Norovirus polypeptide. In some embodiments, the Norovirus is a Genogroup I Norovirus or a Genogroup II Norovirus. In other embodiments, the Norovirus is Norwalk or MD2004 virus. In some embodiments, the monoclonal antibodies specifically bind VP1. Also disclosed are compositions including the disclosed antibodies, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of a Norovirus in a biological sample, or detecting a Norovirus infection. Also disclosed are methods of treating and/or preventing a NoV infection.
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.035 秒)
