公开(公告)号：US20170210767A1

公开(公告)日：2017-07-27

申请号：US15322041

申请日：2015-07-03

Applicant: THE UNIVERSITY OF TOKYO

Inventor： Tomohiko OHWADA ,  Sho NAKAMURA ,  Sejin JUNG ,  Yuko OTANI ,  Misa SAYAMA ,  Junken AOKI

IPC: C07F9/12 ,  C07F9/09

CPC classification number: C07F9/12 ,  A61K31/6615 ,  C07F9/09 ,  C07F9/094 ,  C07F9/113

Abstract: An object of the present invention is to provide a lysophosphatidylserine derivative or a salt thereof.The present invention provides a lysophosphatidylserine derivative or a salt thereof, or a pharmaceutical composition or a lysophosphatidylserine receptor function modulator comprising said compound or a salt thereof.

公开(公告)号：US20160376278A1

公开(公告)日：2016-12-29

申请号：US15120763

申请日：2015-02-26

Applicant: THE UNIVERSITY OF TOKYO ,  TOHOKU UNIVERSITY ,  SHIONOGI & CO., LTD.

Inventor： Tetsuo NAGANO ,  Takayoshi OKABE ,  Hirotatsu KOJIMA ,  Mitsuyasu KAWAGUCHI ,  Osamu NUREKI ,  Ryuichiro ISHITANI ,  Hiroshi NISHIMASU ,  Junken AOKI ,  Chiaki FUJIKOSHI ,  Manabu KATOU ,  Masahide ODAN ,  Nobuyuki TANAKA ,  Yusuke TATENO ,  Junji YAMANE

IPC: C07D487/04 ,  C07D519/00 ,  C07D487/18 ,  C07D491/147

CPC classification number: C07D487/04 ,  C07D487/18 ,  C07D491/147 ,  C07D519/00

Abstract: The present invention provides a compound of formula (1), wherein R1, R2, R3, R4a, R4b, R5a and R5b are as defined in the description, which has an autotaxin inhibitory activity, a pharmaceutical composition comprising the compound as an active ingredient, and a method of prevention or treatment of a disease involving autotaxin, which is characterized by administering the compound.

Abstract translation: 本发明提供了式（I）化合物，其中R 1，R 2，R 3，R 4a，R 4b，R 5a和R 5b如说明书中所定义，其具有自分泌抑素活性，药物组合物 所述化合物包含所述化合物作为活性成分，以及预防或治疗涉及自体吸入素的疾病的方法，其特征在于施用所述化合物。

公开(公告)号：US20160002247A1

公开(公告)日：2016-01-07

申请号：US14770959

申请日：2014-02-27

Applicant: THE UNIVERSITY OF TOKYO ,  TOHOKU UNIVERSITY ,  Shionogi & Co., Ltd.

Inventor： Tetsuo NAGANO ,  Takayoshi OKABE ,  Hirotatsu KOJIMA ,  Mitsuyasu KAWAGUCHI ,  Osamu NUREKI ,  Ryuichiro ISHITANI ,  Hiroshi NISHIMASU ,  Junken AOKI ,  Nobuyuki TANAKA ,  Chiaki FUJIKOSHI ,  Yusuke TATENO ,  Toshihiro WADA

IPC: C07D487/04 ,  C07D519/00

CPC classification number: C07D487/04 ,  C07D519/00

Abstract: A compound of formula (I) wherein variables are as defined herein having an autotaxin inhibitory effect and a pharmaceutical composition comprising the same.

Abstract translation: 式（I）化合物，其中变量如本文所定义，具有自体贴剂抑制作用，以及包含其的药物组合物。

公开(公告)号：US20170158704A1

公开(公告)日：2017-06-08

申请号：US15441385

申请日：2017-02-24

Applicant: The University of Tokyo ,  TOHOKU UNIVERSITY ,  Shionogi & Co., Ltd.

Inventor： Tetsuo NAGANO ,  Takayoshi OKABE ,  Hirotatsu KOJIMA ,  Mitsuyasu KAWAGUCHI ,  Osamu NUREKI ,  Ryuichiro ISHITANI ,  Hiroshi NISHIMASU ,  Junken AOKI ,  Nobuyuki TANAKA ,  Yasuhiko KANDA ,  Yoshiyuki KIOI ,  Yusuke TATENO ,  Shiro KIDA ,  Junji YAMANE

IPC: C07D491/107 ,  C07D239/36 ,  C07D405/12 ,  C07D401/12 ,  C07D403/06 ,  C07D413/06 ,  C07D471/08 ,  C07D409/12 ,  C07D417/12 ,  C07D413/12 ,  C07D403/12 ,  C07D401/04 ,  C07D403/04 ,  C07D471/10 ,  C07D239/47

CPC classification number: C07D491/107 ,  C07D239/36 ,  C07D239/47 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/06 ,  C07D413/12 ,  C07D417/12 ,  C07D471/08 ,  C07D471/10

Abstract: A compound according to any one of formula (Ia) to (Ic), or its pharmaceutically acceptable salt: wherein R1, R2, R3, R4a, R4c, R5 are as defined in the description.

公开(公告)号：US20150361119A1

公开(公告)日：2015-12-17

申请号：US14764808

申请日：2014-01-30

Applicant: THE UNIVERSITY OF TOKYO ,  TOHOKU UNIVERSITY

Inventor： Tomohiko OHWADA ,  Yuko OTANI ,  Masaya IKUBO ,  Sho NAKAMURA ,  Sejin JUNG ,  Junken AOKI ,  Kumiko MAKIDE ,  Asuka INOUE

IPC: C07F9/655 ,  C07F9/09

CPC classification number: C07F9/6552 ,  C07F9/09 ,  C07F9/091

Abstract: The object of the present invention is to provide a compound having a lysophosphatidylserine receptor function modulation activity or a salt thereof.A compound having a lysophosphatidylserine receptor function modulation activity or a salt thereof, or a pharmaceutical composition or a lysophosphatidylserine receptor function moderator containing such compound or salt is provided by the present invention.

Abstract translation: 本发明的目的是提供具有溶血磷脂酰丝氨酸受体功能调节活性的化合物或其盐。 具有溶血磷脂酰丝氨酸受体功能调节活性的化合物或其盐，或含有该化合物或盐的药物组合物或溶血磷脂酰丝氨酸受体功能调节剂由本发明提供。