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1.发明申请OCULAR IMPLANT WITH STIFFNESS QUALITIES, METHODS OF IMPLANTATION AND SYSTEM 有权具有坚固质量的OCULAR植入物，植入和系统的方法公开(公告)号：US20140066831A1
公开(公告)日：2014-03-06
申请号：US14071500
申请日：2013-11-04
IPC分类号： A61F9/007
CPC分类号： A61F9/00781 , A61F2210/0019
摘要： Described herein are devices and methods for treating eye conditions. Described is an ocular implant including an elongate member having an internal lumen forming a flow pathway, at least one inflow port communicating with the flow pathway, and at least one outflow port communicating with the flow pathway. The elongate member is adapted to be positioned in the eye such that at least one inflow port communicates with the anterior chamber, at least one outflow port communicates with the suprachoroidal space to provide a fluid pathway between the anterior chamber and the suprachoroidal space when the elongate member is implanted in the eye. The elongate member has a wall material imparting a stiffness to the elongate member. The stiffness is selected such that after implantation the elongate member deforms eye tissue surrounding the suprachoroidal space forming a tented volume.
摘要翻译： 本文描述了用于治疗眼睛状况的装置和方法。 描述了一种眼部植入物，其包括具有形成流动路径的内部内腔的细长构件，与流动通道连通的至少一个流入口以及与流动通路连通的至少一个流出口。 细长构件适于定位在眼睛中，使得至少一个流入端口与前房连通，至少一个流出端口与脉管外空间连通，以在前房和脉管外空间之间提供流体通路，当细长 成员植入眼睛。 细长构件具有赋予细长构件刚性的壁材料。 选择刚度使得在植入之后，细长构件使围绕脉管外空间的眼组织变形，形成帐篷体积。
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公开(公告)号：US20110112546A1
公开(公告)日：2011-05-12
申请号：US12846201
申请日：2010-07-29
IPC分类号： A61F11/00
CPC分类号： A61F9/0017 , A61B2090/061 , A61B2090/062 , A61F9/0026 , A61F9/007 , A61F9/00781
摘要： Described herein is a delivery device and methods for delivering an ocular implant into an eye. The delivery device includes a proximal handle portion; a distal delivery portion coupled to a distal end of the handle portion and configured to releasably hold an ocular implant and includes a sheath positioned axially over a guidewire; and a metering system configured to provide visual guidance regarding depth of advancement of an implant positioned on the guidewire into an anatomic region of the eye. Also disclosed is a device and method for loading an implant onto the delivery device.
摘要翻译： 本文描述了用于将眼部植入物递送到眼睛中的递送装置和方法。 输送装置包括近端手柄部分; 远端传送部分，其联接到所述手柄部分的远端并且构造成可释放地保持眼睛植入物并且包括轴向地定位在导丝上的护套; 以及计量系统，其被配置为提供关于定位在所述导丝上的植入物的进展深度到所述眼睛的解剖区域中的视觉指导。 还公开了一种用于将植入物装载到输送装置上的装置和方法。
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3.发明申请OCULAR IMPLANT WITH STIFFNESS QUALITIES, METHODS OF IMPLANTATION AND SYSTEM 有权具有坚固质量的OCULAR植入物，植入和系统的方法公开(公告)号：US20120016286A1
公开(公告)日：2012-01-19
申请号：US13245802
申请日：2011-09-26
IPC分类号： A61F9/00
CPC分类号： A61F9/00781 , A61F2210/0019
摘要： Described herein are devices and methods for treating eye conditions. Described is an ocular implant including an elongate member having an internal lumen forming a flow pathway, at least one inflow port communicating with the flow pathway, and at least one outflow port communicating with the flow pathway. The elongate member is adapted to be positioned in the eye such that at least one inflow port communicates with the anterior chamber, at least one outflow port communicates with the suprachoroidal space to provide a fluid pathway between the anterior chamber and the suprachoroidal space when the elongate member is implanted in the eye. The elongate member has a wall material imparting a stiffness to the elongate member. The stiffness is selected such that after implantation the elongate member deforms eye tissue surrounding the suprachoroidal space forming a tented volume.
摘要翻译： 本文描述了用于治疗眼睛状况的装置和方法。 描述了一种眼部植入物，其包括具有形成流动路径的内部内腔的细长构件，与流动通道连通的至少一个流入口以及与流动通路连通的至少一个流出口。 细长构件适于定位在眼睛中，使得至少一个流入端口与前房连通，至少一个流出端口与脉管外空间连通，以在前房和脉管外空间之间提供流体通路， 成员植入眼睛。 细长构件具有赋予细长构件刚性的壁材料。 选择刚度使得在植入之后，细长构件使围绕脉管外空间的眼组织变形，形成帐篷体积。
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4.发明申请OCULAR IMPLANT WITH STIFFNESS QUALITIES, METHODS OF IMPLANTATION AND SYSTEM 有权具有坚固质量的OCULAR植入物，植入和系统的方法公开(公告)号：US20100274258A1
公开(公告)日：2010-10-28
申请号：US12694691
申请日：2010-01-27
CPC分类号： A61F9/00781 , A61F2210/0019
摘要： Described herein are devices and methods for treating eye conditions. Described is an ocular implant including an elongate member having an internal lumen forming a flow pathway, at least one inflow port communicating with the flow pathway, and at least one outflow port communicating with the flow pathway. The elongate member is adapted to be positioned in the eye such that at least one inflow port communicates with the anterior chamber, at least one outflow port communicates with the suprachoroidal space to provide a fluid pathway between the anterior chamber and the suprachoroidal space when the elongate member is implanted in the eye. The elongate member has a wall material imparting a stiffness to the elongate member. The stiffness is selected such that after implantation the elongate member deforms eye tissue surrounding the suprachoroidal space forming a tented volume.
摘要翻译： 本文描述了用于治疗眼睛状况的装置和方法。 描述了一种眼部植入物，其包括具有形成流动路径的内部内腔的细长构件，与流动通道连通的至少一个流入口以及与流动通路连通的至少一个流出口。 细长构件适于定位在眼睛中，使得至少一个流入端口与前房连通，至少一个流出端口与脉管外空间连通，以在前房和脉管外空间之间提供流体通路，当细长 成员植入眼睛。 细长构件具有赋予细长构件刚性的壁材料。 选择刚度使得在植入之后，细长构件使围绕脉管外空间的眼组织变形，形成帐篷体积。
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5.发明申请OCULAR IMPLANT WITH STIFFNESS QUALITIES, METHODS OF IMPLANTATION AND SYSTEM 有权具有坚固质量的OCULAR植入物，植入和系统的方法公开(公告)号：US20110087148A1
公开(公告)日：2011-04-14
申请号：US12970567
申请日：2010-12-16
IPC分类号： A61F9/00
CPC分类号： A61F9/00781 , A61F2210/0019
摘要： Described herein are devices and methods for treating eye conditions. Described is an ocular implant including an elongate member having an internal lumen forming a flow pathway, at least one inflow port communicating with the flow pathway, and at least one outflow port communicating with the flow pathway. The elongate member is adapted to be positioned in the eye such that at least one inflow port communicates with the anterior chamber, at least one outflow port communicates with the suprachoroidal space to provide a fluid pathway between the anterior chamber and the suprachoroidal space when the elongate member is implanted in the eye. The elongate member has a wall material imparting a stiffness to the elongate member. The stiffness is selected such that after implantation the elongate member deforms eye tissue surrounding the suprachoroidal space forming a tented volume.
摘要翻译： 本文描述了用于治疗眼睛状况的装置和方法。 描述了一种眼部植入物，其包括具有形成流动路径的内部内腔的细长构件，与流动通道连通的至少一个流入口以及与流动通路连通的至少一个流出口。 细长构件适于定位在眼睛中，使得至少一个流入端口与前房连通，至少一个流出端口与脉管外空间连通，以在前房和脉管外空间之间提供流体通路，当细长 成员植入眼睛。 细长构件具有赋予细长构件刚性的壁材料。 选择刚度使得在植入之后，细长构件使围绕脉管外空间的眼组织变形，形成帐篷体积。
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公开(公告)号：US20110028983A1
公开(公告)日：2011-02-03
申请号：US12898630
申请日：2010-10-05
IPC分类号： A61F9/007
CPC分类号： A61F9/00781 , A61F2210/0019
摘要： Described herein are devices and methods for treating eye conditions. Described is an ocular implant including an elongate member having an internal lumen forming a flow pathway, at least one inflow port communicating with the flow pathway, and at least one outflow port communicating with the flow pathway. The elongate member is adapted to be positioned in the eye such that at least one inflow port communicates with the anterior chamber, at least one outflow port communicates with the suprachoroidal space to provide a fluid pathway between the anterior chamber and the suprachoroidal space when the elongate member is implanted in the eye. The elongate member has a wall material imparting a stiffness to the elongate member. The stiffness is selected such that after implantation the elongate member deforms eye tissue surrounding the suprachoroidal space forming a tented volume.
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公开(公告)号：US20140358125A1
公开(公告)日：2014-12-04
申请号：US14236863
申请日：2012-08-03
申请人： Eugene de Juan, JR. , Yair Alster , Kathleen Cogan Farinas , K. Angela MacFarlane , Cary J. Reich , Randolph E. Campbell , Signe Erickson
发明人： Eugene de Juan, JR. , Yair Alster , Kathleen Cogan Farinas , K. Angela MacFarlane , Cary J. Reich , Randolph E. Campbell , Signe Erickson
IPC分类号： A61F9/00 , A61K31/382
CPC分类号： A61F9/0017 , A61F2250/0031 , A61F2250/0068 , A61K9/0051 , A61K31/382 , A61K31/407 , A61K31/519 , F04C2270/041
摘要： A therapeutic device that can release a therapeutic agent comprising a porous structure coupled to a container comprising a reservoir. The reservoir can comprise a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in a patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. The length of the channels extending from the first side to the second side may comprise an effective length greater than a distance across the porous structure from the first side to the second side. The therapeutic device may comprise a penetrable barrier to inject therapeutic agent into the device when implanted in the patient.
摘要翻译： 一种能够释放治疗剂的治疗装置，所述治疗剂包括与包含储存器的容器相连的多孔结构。 贮存器可以包含一定量的体积，当耦合到多孔结构并且植入患者体内时，释放处理量的治疗剂延长时间。 所述多孔结构可以包括联接到所述储存器的第一侧和与所述患者联接以释放所述治疗剂的第二侧。 从第一侧延伸到第二侧的通道的长度可以包括大于多孔结构从第一侧到第二侧的距离的有效长度。 治疗装置可以包括当植入患者时将治疗剂注射到装置中的可穿透屏障。
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公开(公告)号：US20140031769A1
公开(公告)日：2014-01-30
申请号：US13988298
申请日：2011-11-18
申请人： Eugene de Juan, JR. , Yair Alster , Steven M. Chamow , Kathleen Cogan Farinas , K. Angela MacFarlane , Cary J. Reich , Randolph E. Campbell , Signe Erickson , Blaine Bueche
发明人： Eugene de Juan, JR. , Yair Alster , Steven M. Chamow , Kathleen Cogan Farinas , K. Angela MacFarlane , Cary J. Reich , Randolph E. Campbell , Signe Erickson , Blaine Bueche
IPC分类号： A61F9/00
CPC分类号： A61F9/0017 , A61K9/0051 , A61K9/1647 , A61K9/1652 , A61K31/573
摘要： An injectable formulation of therapeutic agent may comprise the therapeutic agent and a stabilizer such that a substantial portion of the stabilizer remains in the therapeutic device to stabilize the therapeutic agent when the therapeutic agent is released from the therapeutic device. The injectable formulation may comprise one or more of binding agent particles or erodible material particles, such that the formulation can be injected into the therapeutic device. The binding agent particles can bind reversibly to the therapeutic agent so as to modulate release of the therapeutic agent, and the erodible material particles can generate protons of an acid so as to increase stability of the therapeutic agent and may modulate release of the therapeutic agent. The therapeutic agent can be combined with one or more of the stabilizer, the binding agent particles or the erodible particles to increase stability of the therapeutic agent and may modulate release.
摘要翻译： 治疗剂的可注射制剂可以包含治疗剂和稳定剂，使得当治疗剂从治疗装置释放时，大部分稳定剂保留在治疗装置中以稳定治疗剂。 可注射制剂可以包含一种或多种粘合剂颗粒或可侵蚀材料颗粒，使得可以将制剂注射到治疗装置中。 结合剂颗粒可以可逆地结合治疗剂以调节治疗剂的释放，并且可侵蚀的材料颗粒可以产生酸的质子，以增加治疗剂的稳定性并且可以调节治疗剂的释放。 治疗剂可以与稳定剂，结合剂颗粒或可侵蚀颗粒中的一种或多种组合以增加治疗剂的稳定性并且可以调节释放。
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公开(公告)号：US20130324942A1
公开(公告)日：2013-12-05
申请号：US13814464
申请日：2011-08-05
申请人： Eugene de Juan, JR. , Yair Alster , Kathleen Cogan Farinas , K. Angela MacFarlane , Cary J. Reich , Randolph E. Campbell
发明人： Eugene de Juan, JR. , Yair Alster , Kathleen Cogan Farinas , K. Angela MacFarlane , Cary J. Reich , Randolph E. Campbell
IPC分类号： A61F9/00
CPC分类号： A61F9/0017 , A61K9/0051
摘要： A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. The length of the channels extending from the first side to the second side may comprise an effective length greater than a distance across the porous structure from the first side to the 188 second side. The therapeutic device may comprise a penetrable barrier to inject therapeutic agent into the device when implanted in the patient.
摘要翻译： 用于释放治疗剂的治疗装置包括联接到包括储存器的容器的多孔结构。 储存器包括体积大小，当耦合到多孔结构并且植入患者体内时，释放治疗剂量的治疗剂延长的时间。 所述多孔结构可以包括联接到所述储存器的第一侧和与所述患者联接以释放所述治疗剂的第二侧。 从第一侧延伸到第二侧的通道的长度可以包括大于多孔结构从第一侧到第188侧的距离的有效长度。 治疗装置可以包括当植入患者时将治疗剂注射到装置中的可穿透屏障。
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公开(公告)号：US20130165860A1
公开(公告)日：2013-06-27
申请号：US13615229
申请日：2012-09-13
申请人： Darren Doud , Randolph E. Campbell , Signe Erickson , K. Angela MacFarlane , Mike Barrett , Christina Skieller , David Batten , Greg Stine , Eugene de Juan, JR. , Douglas Sutton , Kathleen Cogan Farinas
发明人： Darren Doud , Randolph E. Campbell , Signe Erickson , K. Angela MacFarlane , Mike Barrett , Christina Skieller , David Batten , Greg Stine , Eugene de Juan, JR. , Douglas Sutton , Kathleen Cogan Farinas
CPC分类号： A61F9/0008 , A61F9/0017 , A61M5/141 , A61M5/14276 , A61M5/3202 , A61M5/3291 , A61M5/46 , A61M25/007 , A61M39/0247 , A61M2025/0031 , A61M2025/0039 , A61M2039/0081 , A61M2039/009 , A61M2039/027 , A61M2039/0276 , A61M2039/0294 , A61M2205/6045 , A61M2205/6054 , A61M2209/045 , A61M2210/0612
摘要： An injector apparatus comprises an elongate structure having one or more openings positionable near a penetrable barrier of an implantable device so as to receive fluid of the implantable device. The apparatus comprises a needle and a sheath extending over at least a portion of the needle. The elongate structure may comprise a distal tip to penetrate tissue and the penetrable barrier, and a distal opening near the tip to release therapeutic fluid into the implantable chamber. In many embodiments the distal tip, the distal opening, and the plurality of openings are separated from a stop that engages a tissue of the patient and limit penetration depth such that the distal opening and the plurality of openings are located along an axis of the implantable device to increase an efficiency of the exchange.
摘要翻译： 注射器装置包括具有一个或多个开口的细长结构，其可定位在可植入装置的可穿透屏障附近，以便容纳可植入装置的流体。 该装置包括在针的至少一部分上延伸的针和护套。 细长结构可以包括穿透组织和可穿透屏障的远端尖端，以及靠近尖端的远端开口以将治疗流体释放到可植入腔室中。 在许多实施例中，远端尖端，远侧开口和多个开口与接合患者组织的止挡分开并限制穿透深度，使得远端开口和多个开口沿着可植入的轴线 设备提高交换效率。
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