公开(公告)号：US20220195013A1

公开(公告)日：2022-06-23

申请号：US17693785

申请日：2022-03-14

Applicant: THROMBOSIS RESEARCH INSTITUTE

Inventor： Xinjie Lu ,  Vijay Kakkar

IPC: C07K14/775 ,  A61K39/00 ,  A61K39/118 ,  C07K14/195 ,  C07K14/35 ,  C07K14/295 ,  C07K14/47 ,  C07K14/705

Abstract: The invention relates to multiple epitope constructs, immunogenic and vaccine compositions comprising recombinant molecules presenting inserted multiple and different epitopes from a variety of antigens. The antigenic determinants being associated with different pathways leading to atherosclerosis. In particular, the invention relates to such compositions for eliciting an immune response against antigens and pathogens involved in the development of atherosclerosis. The invention includes inter alia methods of treating and/or preventing the disease and recombinant protein products.

公开(公告)号：US11332515B2

公开(公告)日：2022-05-17

申请号：US15546858

申请日：2016-01-25

Applicant: THROMBOSIS RESEARCH INSTITUTE ,  Lord Kakkar

Inventor： Vijay Kakkar ,  Xinjie Lu

IPC: C07K14/775 ,  A61K39/00 ,  A61K39/118 ,  C07K14/195 ,  C07K14/35 ,  C07K14/295 ,  C07K14/47 ,  C07K14/705

Abstract: The invention relates to multiple epitope constructs, immunogenic and vaccine compositions comprising recombinant molecules presenting inserted multiple and different epitopes from a variety of antigens. The antigenic determinants being associated with different pathways leading to atherosclerosis. In particular, the invention relates to such compositions for eliciting an immune response against antigens and pathogens involved in the development of atherosclerosis the invention includes inter alia methods of treating and/or preventing the disease and recombinant protein products.

公开(公告)号：US20180273608A1

公开(公告)日：2018-09-27

申请号：US15546858

申请日：2016-01-25

Applicant: THROMBOSIS RESEARCH INSTITUTE

Inventor： Vijay Kakkar ,  Xinjie Lu

IPC: C07K14/775 ,  C07K14/47 ,  C07K14/295 ,  C07K14/705 ,  A61K39/00 ,  A61K39/118

CPC classification number: C07K14/775 ,  A61K39/0005 ,  A61K39/0008 ,  A61K39/0012 ,  A61K39/118 ,  A61K2039/58 ,  A61K2039/6081 ,  A61K2039/64 ,  C07K14/195 ,  C07K14/295 ,  C07K14/35 ,  C07K14/47 ,  C07K14/70596

Abstract: The invention relates to multiple epitope constructs, immunogenic and vaccine compositions comprising recombinant molecules presenting inserted multiple and different epitopes from a variety of antigens. The antigenic determinants being associated with different pathways leading to atherosclerosis. In particular, the invention relates to such compositions for eliciting an immune response against antigens and pathogens involved in the development of atherosclerosis the invention includes inter alia methods of treating and/or preventing the disease and recombinant protein products