公开(公告)号：US20240132467A1

公开(公告)日：2024-04-25

申请号：US18332551

申请日：2023-06-09

Applicant: TMEM16A Limited

Inventor： Stephen COLLINGWOOD ,  Jonathan David Hargrave ,  Duncan Alexander Hay ,  Clive McCarthy ,  Thomas Beauregard Schofield ,  Edward Walker ,  Naomi Went

IPC: C07D401/06 ,  A61P11/12 ,  C07D235/08 ,  C07D235/12 ,  C07D235/16 ,  C07D405/04 ,  C07D413/06

CPC classification number: C07D401/06 ,  A61P11/12 ,  C07D235/08 ,  C07D235/12 ,  C07D235/16 ,  C07D405/04 ,  C07D413/06

Abstract: Compounds of general formula (I): (I) wherein R1, R2, R3, R4, R5, Y and Z are as defined herein are useful for treating respiratory disease and other diseases and conditions modulated by TMEM16A.

公开(公告)号：US20220235006A1

公开(公告)日：2022-07-28

申请号：US17581504

申请日：2022-01-21

Applicant: TMEM16A LIMITED

Inventor： Stephen COLLINGWOOD ,  Craig BUXTON ,  Jonathan David HARGRAVE ,  Peter INGRAM ,  Thomas Beauregard SCHOFIELD ,  Abdul SHAIKH ,  Christopher STIMSON

IPC: C07D213/81

Abstract: Compounds of general formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are as defined herein are useful for treating respiratory disease and other diseases and conditions modulated by TMEM16A.

公开(公告)号：US20220098167A1

公开(公告)日：2022-03-31

申请号：US17547940

申请日：2021-12-10

Applicant: TMEM16A Limited

Inventor： Stephen COLLINGWOOD ,  Clive MCCARTHY ,  Duncan Alexander HAY ,  Jonathan David HARGRAVE ,  Albert MA ,  Thomas Beauregard SCHOFIELD ,  Matthew SMITH ,  Edward WALKER ,  Naomi WENT ,  Peter INGRAM ,  Christopher STIMSON ,  Someina KHOR

IPC: C07D401/06 ,  C07D235/08 ,  C07D405/06 ,  C07D413/10 ,  C07D405/12 ,  C07D263/56 ,  C07D231/56 ,  C07D471/04

Abstract: Compounds of general formula (I) and their tautomeric forms all enantiomers and isotopic variants and salts and solvates thereof: wherein represents a single or a double bond and R1, R2, X1, X2, X3, X4, X5, Y and Z are as defined herein; are useful for treating respiratory disease and other diseases and conditions modulated by TMEM16A.

公开(公告)号：US20220098164A1

公开(公告)日：2022-03-31

申请号：US17547967

申请日：2021-12-10

Applicant: TMEM16A Limited

Inventor： Stephen COLLINGWOOD ,  Jonathan David HARGRAVE ,  Duncan Alexander HAY ,  Edward WALKER

IPC: C07D333/36 ,  C07C233/07 ,  C07D213/56 ,  C07D213/127 ,  C07D213/72

Abstract: Compounds of general formula (I): wherein R1, R2, R3, R4, A, Z1, Z2 and Y are as defined herein are useful for treating respiratory disease and other diseases and conditions modulated by TMEM16A.

公开(公告)号：US20220220074A1

公开(公告)日：2022-07-14

申请号：US17582539

申请日：2022-01-24

Applicant: TMEM16A LIMITED

Inventor： Stephen COLLINGWOOD ,  Robert MELLING

IPC: C07D213/81

Abstract: The invention relates to novel forms of N-tert-Butyl-4-[[2-(5-chloro-2-hydroxy- phenyl)acetyl]amino]pyridine-2-car-boxamide (Compound 1). In particular, the invention relates to the Form A and Form B crystalline polymorphs and the amorphous form.

公开(公告)号：US20220144803A1

公开(公告)日：2022-05-12

申请号：US17581520

申请日：2022-01-21

Applicant: TMEM16A LIMITED

Inventor： Stephen COLLINGWOOD ,  Craig BUXTON ,  Matthew HABGOOD ,  Jonathan David HARGRAVE ,  Thomas Beauregard SCHOFIELD ,  Matthew SMITH ,  Christopher STIMSON

IPC: C07D401/12 ,  C07D405/14

Abstract: Compounds of general formula (I), wherein R1, R2, R3, R4, R5, X1, X2 and X3 are as defined herein are useful for treating respiratory disease and other diseases and conditions modulated by TMEM16A.