公开(公告)号：US20150110746A1

公开(公告)日：2015-04-23

申请号：US14580366

申请日：2014-12-23

申请人： TRANSGENE S.A.

发明人： Daniel Malarme ,  Yves Cordier ,  Claude Sene

IPC分类号： A61K35/76

CPC分类号： A61K35/76 ,  A61K39/0011 ,  A61K39/12 ,  A61K48/00 ,  A61K2039/5256 ,  A61K2039/55533 ,  A61K2039/585 ,  C07K14/82 ,  C07K2319/01 ,  C12N7/00 ,  C12N7/02 ,  C12N15/86 ,  C12N2500/24 ,  C12N2501/11 ,  C12N2510/02 ,  C12N2710/20034 ,  C12N2710/24143 ,  C12N2710/24151

摘要： The present invention relates to compositions and pharmaceutical compositions comprising poxviruses and more particularly extracellular enveloped viruses. The present invention also relates to a process for producing poxviruses and poxviruses obtained thereof. Moreover, the present invention also relates to the use of said poxvirus and said composition for the preparation of a medicament.

摘要翻译： 本发明涉及包含痘病毒，更特别是细胞外包膜病毒的组合物和药物组合物。 本发明还涉及生产痘病毒和痘病毒的方法。 此外，本发明还涉及所述痘病毒和所述组合物在制备药物中的用途。

公开(公告)号：US09295702B2

公开(公告)日：2016-03-29

申请号：US14580366

申请日：2014-12-23

申请人： TRANSGENE S.A.

发明人： Daniel Malarme ,  Yves Cordier ,  Claude Sene

IPC分类号： A61K35/76 ,  A61K39/12 ,  C07K14/82 ,  C12N7/00 ,  C12N15/86 ,  C12N7/02 ,  A61K48/00 ,  A61K39/00

CPC分类号： A61K35/76 ,  A61K39/0011 ,  A61K39/12 ,  A61K48/00 ,  A61K2039/5256 ,  A61K2039/55533 ,  A61K2039/585 ,  C07K14/82 ,  C07K2319/01 ,  C12N7/00 ,  C12N7/02 ,  C12N15/86 ,  C12N2500/24 ,  C12N2501/11 ,  C12N2510/02 ,  C12N2710/20034 ,  C12N2710/24143 ,  C12N2710/24151

摘要： The present invention relates to compositions and pharmaceutical compositions comprising poxviruses and more particularly extracellular enveloped viruses. The present invention also relates to a process for producing poxviruses and poxviruses obtained thereof. Moreover, the present invention also relates to the use of said poxvirus and said composition for the preparation of a medicament.

公开(公告)号：US09012198B2

公开(公告)日：2015-04-21

申请号：US14077621

申请日：2013-11-12

申请人： Transgene S.A.

发明人： Claude Sene ,  Sylvie Campourcy ,  Yves Cordier

IPC分类号： C12N7/02 ,  C12N7/00 ,  C12N15/86 ,  C12P21/00

CPC分类号： C12N7/025 ,  A61K35/768 ,  C12N7/00 ,  C12N7/02 ,  C12N15/86 ,  C12N2710/24152 ,  C12N2710/24251 ,  C12P21/00 ,  Y02A50/388 ,  Y02A50/39

摘要： The present invention relates to a method for producing and purifying a wild type, an attenuated and/or a recombinant Orthopoxvirus. The present invention relates to a purified wild type, attenuated and/or recombinant Orthopoxvirus obtained by the method of the invention and to a pharmaceutical composition, preferably a vaccine, comprising said purified Orthopoxvirus for the treatment and/or the prevention a cancer, an infectious disease and/or an autoimmune disorder, and uses thereof. The present invention also relates to the use of an immortalized avian cell line obtained from an avian cell belonging to the Anatidae family, in particular Cairina moschata immortalized avian cell lines comprising a nucleic acid sequence coding a telomerase reverse transcriptase (TERT) and optionally an E1A nucleic acid sequence, for the production of a wild type, attenuated and/or recombinant Orthopoxvirus according to the process of the invention.

摘要翻译： 本发明涉及一种生产和纯化野生型，减毒和/或重组直痘病毒的方法。 本发明涉及通过本发明方法获得的纯化的野生型，减毒和/或重组的直痘病毒，以及包含用于治疗和/或预防癌症的感染性的包含所述纯化的直痘病毒的药物组合物，优选疫苗 疾病和/或自身免疫性疾病及其用途。 本发明还涉及从属于id科家禽的禽类细胞，特别是Cairina moschata永生化鸟类细胞系获得的永生化鸟类细胞系的用途，其包含编码端粒酶逆转录酶（TERT）和任选的E1A的核酸序列 核酸序列，用于根据本发明的方法生产野生型，减毒和/或重组的直链痘病毒。