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    Virus-containing formulation and use thereof
    2.
    发明授权
    Virus-containing formulation and use thereof 有权

    公开(公告)号：US10111947B2

    公开(公告)日：2018-10-30

    申请号：US14433142

    申请日：2013-10-02

    申请人： Transgene S.A.

    发明人： Claude Sene ,  Mélina Chasle

    IPC分类号： C12N7/00 ,  A61K39/285 ,  A61K47/18 ,  A61K47/32 ,  A61K9/19 ,  A61K47/26 ,  A61K47/02

    摘要： The present invention relates to formulation comprising (i) at least one virus-based material, (ii) at least one polymer selected in the group of polyvinylpyrrolidone and derivatives thereof, (iii) at least one sugar, (iv) at least two different amino acids, (v) at least two pharmaceutical acceptable salts, wherein at least one of said salts is a phosphate salt and, optionally (vi) a pharmaceutical acceptable buffer. Such a formulation is particularly suitable for freeze-drying. The present invention also relates to the corresponding dry product, as well as its preparation process. The present invention also relates to a reconstituted material comprising said dry product, which can be administered to a patient in need thereof. Such formulation and reconstituted material are useful as vaccines, preferably for the treatment and/or the prevention of cancers, infectious diseases and/or autoimmune disorders.

    Method for orthopoxvirus production and purification
    4.
    发明授权
    Method for orthopoxvirus production and purification 有权
    正痘病毒生产和纯化方法

    公开(公告)号：US09012198B2

    公开(公告)日：2015-04-21

    申请号：US14077621

    申请日：2013-11-12

    申请人： Transgene S.A.

    发明人： Claude Sene ,  Sylvie Campourcy ,  Yves Cordier

    IPC分类号： C12N7/02 ,  C12N7/00 ,  C12N15/86 ,  C12P21/00

    CPC分类号： C12N7/025 ,  A61K35/768 ,  C12N7/00 ,  C12N7/02 ,  C12N15/86 ,  C12N2710/24152 ,  C12N2710/24251 ,  C12P21/00 ,  Y02A50/388 ,  Y02A50/39

    摘要： The present invention relates to a method for producing and purifying a wild type, an attenuated and/or a recombinant Orthopoxvirus. The present invention relates to a purified wild type, attenuated and/or recombinant Orthopoxvirus obtained by the method of the invention and to a pharmaceutical composition, preferably a vaccine, comprising said purified Orthopoxvirus for the treatment and/or the prevention a cancer, an infectious disease and/or an autoimmune disorder, and uses thereof. The present invention also relates to the use of an immortalized avian cell line obtained from an avian cell belonging to the Anatidae family, in particular Cairina moschata immortalized avian cell lines comprising a nucleic acid sequence coding a telomerase reverse transcriptase (TERT) and optionally an E1A nucleic acid sequence, for the production of a wild type, attenuated and/or recombinant Orthopoxvirus according to the process of the invention.

    摘要翻译： 本发明涉及一种生产和纯化野生型，减毒和/或重组直痘病毒的方法。 本发明涉及通过本发明方法获得的纯化的野生型，减毒和/或重组的直痘病毒，以及包含用于治疗和/或预防癌症的感染性的包含所述纯化的直痘病毒的药物组合物，优选疫苗 疾病和/或自身免疫性疾病及其用途。 本发明还涉及从属于id科家禽的禽类细胞，特别是Cairina moschata永生化鸟类细胞系获得的永生化鸟类细胞系的用途，其包含编码端粒酶逆转录酶（TERT）和任选的E1A的核酸序列 核酸序列，用于根据本发明的方法生产野生型，减毒和/或重组的直链痘病毒。