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公开(公告)号：US20190055304A1
公开(公告)日：2019-02-21
申请号：US16181260
申请日：2018-11-05
发明人： Lawrence M. KAUVAR , Stefan RYSER , Angeles ESTELLES , Reyna J. SIMON , Lauren Opremcak BAKALETZ , Steven David GOODMAN
IPC分类号： C07K16/12 , G01N33/566 , G01N33/569 , A61K39/40 , A61K45/06 , C07K14/31 , A61K49/00 , C12Q1/18
摘要： Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies suitable for administration to a selected species, and antibody mimics including aptamer nucleic acids. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.
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公开(公告)号：US20150086561A1
公开(公告)日：2015-03-26
申请号：US14497147
申请日：2014-09-25
发明人： Lawrence M. KAUVAR , Stefan RYSER , Angeles ESTELLES , Robert STEPHENSON , Reyna J. SIMON , Omar NOURZAIE
IPC分类号： C07K16/12 , C07K14/285 , G01N33/569 , A61K39/104 , A61K39/108 , A61K39/102 , C07K7/08 , A61K39/085
CPC分类号： C07K16/1271 , C07K7/08 , C07K16/1214 , C07K16/1228 , C07K16/1242 , C07K16/1275 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/92 , C12Q1/18 , G01N33/566 , G01N33/56911 , G01N2333/21 , G01N2333/245 , G01N2333/26 , G01N2333/285 , G01N2500/04
摘要： Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies secreted by human B lymphocytes. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.
摘要翻译： 描述了能够破坏不同来源的细菌生物膜的结合剂，包括由人B淋巴细胞分泌的单克隆抗体。 还描述了防止用这些结合剂形成或溶解生物膜的方法。 还描述了用于引发抗体破坏生物膜的免疫原。
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公开(公告)号：US20160237145A1
公开(公告)日：2016-08-18
申请号：US15144681
申请日：2016-05-02
IPC分类号： C07K16/12 , A01N63/02 , G01N33/577 , A61K49/00 , C07K14/31 , G01N33/569 , A61K39/40 , A61K45/06
CPC分类号： C07K16/1271 , A01N63/02 , A61K39/00 , A61K39/40 , A61K45/06 , A61K49/00 , A61K2039/505 , C07K14/31 , C07K16/1214 , C07K16/1228 , C07K16/1242 , C07K16/1275 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C12Q1/18 , G01N33/566 , G01N33/56911 , G01N2333/195 , G01N2333/21 , G01N2333/245 , G01N2333/26 , G01N2333/285 , G01N2469/10 , A61K2300/00
摘要： Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies suitable for administration to a selected species, and antibody mimics including aptamer nucleic acids. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.
摘要翻译： 描述了能够破坏不同来源的细菌生物膜的结合剂，包括适合于给予所选物种的单克隆抗体，以及包括适体核酸的抗体模拟物。 还描述了防止用这些结合剂形成或溶解生物膜的方法。 还描述了用于引发抗体破坏生物膜的免疫原。
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公开(公告)号：US20150197558A1
公开(公告)日：2015-07-16
申请号：US14668767
申请日：2015-03-25
发明人： Lawrence M. KAUVAR , Stefan RYSER , Angeles ESTELLES , Robert STEPHENSON , Reyna J. SIMON , Omar NOURZAIE
IPC分类号： C07K16/12 , A61K39/40 , C12N15/115 , A61K45/06
CPC分类号： C07K16/1271 , A61K39/40 , A61K45/06 , C07K16/1214 , C07K16/1228 , C07K16/1242 , C07K16/1275 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/92 , C12N15/115 , C12N2310/16 , C12N2310/3181 , C12N2330/00 , C12Q1/18 , G01N33/566 , G01N33/56911 , G01N2333/21 , G01N2333/245 , G01N2333/26 , G01N2333/285 , Y02A50/57
摘要： Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies suitable for administration to a selected species and decoy nucleic acids. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.
摘要翻译： 描述了能够破坏不同来源的细菌生物膜的结合剂，包括适合于施用于选定物种和诱饵核酸的单克隆抗体。 还描述了防止用这些结合剂形成或溶解生物膜的方法。 还描述了用于引发抗体破坏生物膜的免疫原。
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公开(公告)号：US20180186880A1
公开(公告)日：2018-07-05
申请号：US15861410
申请日：2018-01-03
CPC分类号： C07K16/2803 , A61P35/00 , C07K16/2827 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： Novel monoclonal antibodies directed against immune checkpoint modulator (ICM) proteins TIM-3 and B7-H3 are useful in treating cancer and immune system disorders.
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公开(公告)号：US20150299298A1
公开(公告)日：2015-10-22
申请号：US14789842
申请日：2015-07-01
发明人： Lawrence M. KAUVAR , Stefan RYSER , Angeles ESTELLES , Robert STEPHENSON , Reyna J. SIMON , Omar NOURZAIE
IPC分类号： C07K16/12 , G01N33/68 , C12N15/115 , C07K7/06 , A01N63/02
CPC分类号： C07K16/1242 , A01N63/02 , A61K39/00 , A61K39/40 , A61K45/06 , A61K2039/505 , C07K16/1214 , C07K16/1217 , C07K16/1228 , C07K16/1271 , C07K16/1275 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/115 , C12N2310/16 , C12N2310/3181 , C12Q1/18 , G01N33/566 , G01N33/56911 , G01N33/68 , G01N2333/21 , G01N2333/245 , G01N2333/26 , G01N2333/285 , Y02A50/57 , A61K2300/00
摘要： Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies suitable for administration to a selected species and decoy nucleic acids. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.
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公开(公告)号：US20220259294A1
公开(公告)日：2022-08-18
申请号：US17569377
申请日：2022-01-05
发明人： Lawrence M. KAUVAR , Stefan RYSER , Angeles ESTELLES , Reyna J. SIMON , Lauren Opremcak BAKALETZ , Steven David GOODMAN
IPC分类号： C07K16/12 , A61K39/40 , A61K45/06 , A61K49/00 , C07K14/31 , C12Q1/18 , G01N33/566 , G01N33/569
摘要： Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies secreted by human B lymphocytes. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.
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公开(公告)号：US20210277116A1
公开(公告)日：2021-09-09
申请号：US17328239
申请日：2021-05-24
摘要： Novel monoclonal antibodies directed against immune checkpoint modulator (ICM) proteins TIM-3 and B7-H3 are useful in treating cancer and immune system disorders.
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9.发明申请公开(公告)号：US20210054075A1
公开(公告)日：2021-02-25
申请号：US17091526
申请日：2020-11-06
IPC分类号： C07K16/28 , A61K39/395 , A61K45/06
摘要： Monoclonal antibodies derived from the native human repertoire that bind the extracellular portion of Killer IgG Receptor (KIR) and pharmaceutical and veterinary compositions thereof are useful in treating cancer in human and other subjects.
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10.发明申请公开(公告)号：US20180002420A1
公开(公告)日：2018-01-04
申请号：US15619327
申请日：2017-06-09
IPC分类号： C07K16/28 , A61K39/395 , A61K45/06
摘要： Monoclonal antibodies derived from the native human repertoire that bind the extracellular portion of Killer IgG Receptor (KIR) and pharmaceutical and veterinary compositions thereof are useful in treating cancer in human and other subjects.
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