公开(公告)号：US11952425B2

公开(公告)日：2024-04-09

申请号：US17318310

申请日：2021-05-12

Applicant: TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Margaret Ackerman ,  Casey Hua ,  Charles Sentman

IPC: C07K16/28 ,  A61K47/68 ,  A61K51/10 ,  A61P35/00 ,  C07K14/705 ,  C07K14/725 ,  C07K16/46

CPC classification number: C07K16/2827 ,  A61K47/6803 ,  A61K47/6849 ,  A61K51/1027 ,  A61K51/1093 ,  A61P35/00 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70521 ,  C07K16/2809 ,  C07K16/468 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/033

Abstract: Provided herein, in some embodiments, are antibodies, antigen-binding antibody fragments, chimeric antigen receptors (CARs) and bispecific T cell engagers (BiTEs) that bind specifically to B7 homolog 6. Also provided herein are methods of using the same and cells comprising the same.

公开(公告)号：US20200369773A1

公开(公告)日：2020-11-26

申请号：US16639836

申请日：2018-08-20

Applicant: CELDARA MEDICAL LLC ,  THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Michael Whitfield ,  Patricia Pioli ,  Charles Sentman ,  Jake Reder ,  Joana Murad ,  Yolanda Nesbeth

IPC: C07K16/28 ,  A61K35/17

Abstract: The invention provides chimeric antigen receptors (CARs), nucleic acid sequences encoding a CAR, vectors comprising a nucleic acid sequence encoding a CAR, cells expressing a CAR, pharmaceutical compositions comprising a cell expressing a CAR, wherein the CAR binds to a target molecule expressed on disease-associated macrophages or over- or aberrantly-expressed in fibrosis. The invention further provides vectors encoding a CAR and a fibrotic disease-modulatory molecule (FDMM), and cells expressing both a CAR and an FDMM. The invention also provides methods of treating a subject using a CAR, a nucleic acid sequence, a vector or vectors, or a CAR-expressing cell, a cell expressing both a CAR and an FDMM, or a pharmaceutical composition, and to methods of generating a CAR-expressing cell or a cell expressing both a CAR and an FDMM. The invention also provides methods of treating diseases, fibrotic conditions, inflammatory conditions, autoimmune conditions, and conditions associated with disease-associated macrophages (DAMs).

公开(公告)号：US20210340258A1

公开(公告)日：2021-11-04

申请号：US17318310

申请日：2021-05-12

Applicant: TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Margaret Ackerman ,  Casey Hua ,  Charles Sentman

IPC: C07K16/28 ,  A61K47/68 ,  C07K14/705 ,  C07K16/46 ,  C07K14/725 ,  A61P35/00 ,  A61K51/10

Abstract: Provided herein, in some embodiments, are antibodies, antigen-binding antibody fragments, chimeric antigen receptors (CARs) and bispecific T cell engagers (BiTEs) that bind specifically to 137 homolog 6. Also provided herein are methods of using the same and cells comprising the same.

公开(公告)号：US11034767B2

公开(公告)日：2021-06-15

申请号：US16092681

申请日：2017-04-14

Applicant: Trustees of Dartmouth College

Inventor： Margaret Ackerman ,  Casey Hua ,  Charles Sentman

IPC: C07K16/28 ,  A61K47/68 ,  A61P35/00 ,  A61K51/10 ,  C07K14/725 ,  C07K14/705 ,  C07K16/46

Abstract: Provided herein, in some embodiments, are antibodies, antigen-binding antibody fragments, chimeric antigen receptors (CARs) and bispecific T cell engagers (BiTEs) that bind specifically to B7 homolog 6. Also provided herein are methods of using the same and cells comprising the same.

公开(公告)号：US20190127470A1

公开(公告)日：2019-05-02

申请号：US16092681

申请日：2017-04-14

Applicant: Trustees of Dartmouth College

Inventor： Margaret Ackerman ,  Casey Hua ,  Charles Sentman

IPC: C07K16/28 ,  C07K14/725 ,  C07K14/705 ,  C07K16/46 ,  A61K47/68 ,  A61K51/10 ,  A61P35/00

Abstract: Provided herein, in some embodiments, are antibodies, antigen-binding antibody fragments, chimeric antigen receptors (CARs) and bispecific T cell engagers (BiTEs) that bind specifically to B7 homolog 6. Also provided herein are methods of using the same and cells comprising the same.

公开(公告)号：US20250059281A1

公开(公告)日：2025-02-20

申请号：US18598013

申请日：2024-03-07

Applicant: TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Margaret Ackerman ,  Casey Hua ,  Charles Sentman

IPC: C07K16/28 ,  A61K39/00 ,  A61K47/68 ,  A61K51/10 ,  A61P35/00 ,  C07K14/705 ,  C07K14/725 ,  C07K16/46

Abstract: Provided herein, in some embodiments, are antibodies, antigen-binding antibody fragments, chimeric antigen receptors (CARs) and bispecific T cell engagers (BiTEs) that bind specifically to B7 homolog 6. Also provided herein are methods of using the same and cells comprising the same.

公开(公告)号：US11857571B2

公开(公告)日：2024-01-02

申请号：US16994795

申请日：2020-08-17

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Charles Sentman ,  Michael Battles

IPC: A61K35/17 ,  C07K16/28 ,  A61K47/68 ,  A61P35/00 ,  A61K51/10 ,  A61K39/00

CPC classification number: A61K35/17 ,  A61K47/6835 ,  A61K51/1045 ,  A61K51/1096 ,  A61P35/00 ,  C07K16/2809 ,  C07K16/2833 ,  C07K16/2851 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/622 ,  C07K2319/03

Abstract: Antigen binding fragments, chimeric antigen receptors, and bi-specific T-cell engagers having specificity for MICA and methods for using the same in the diagnosis and treatment of disorders associated with MICA and/or MICB expression are provided.

公开(公告)号：US10744157B2

公开(公告)日：2020-08-18

申请号：US15561748

申请日：2016-03-25

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Charles Sentman ,  Michael Battles

IPC: C07K16/28 ,  A61K35/17 ,  A61K47/68 ,  A61P35/00 ,  A61K51/10 ,  A61K39/00

Abstract: Antigen binding fragments, chimeric antigen receptors, and bi-specific T-cell engagers having specificity for MICA and methods for using the same in the diagnosis and treatment of disorders associated with MICA and/or MICB expression are provided.