公开(公告)号：US10918525B2

公开(公告)日：2021-02-16

申请号：US16288966

申请日：2019-02-28

申请人： Tusker Medical, Inc.

发明人： Bernard H. Andreas ,  Rohit Girotra ,  Jeffrey A. Walker ,  T. Daniel Gross ,  Mathew D. Clopp ,  Mahyar Z. Kermani ,  Scott J. Baron

IPC分类号： A61F11/00

摘要： A tympanostomy tube delivery device comprises a shaft assembly, a pressure equalization tube, and a sensor. The shaft assembly comprises a cannula and a pusher operable to translate relative to the cannula. The pressure equalization tube is positioned within the shaft assembly. The pusher is operable to drive the pressure equalization tube out of the shaft assembly. The sensor is operable to detect a physical parameter associated with engagement between the distal end of the shaft assembly and a tympanic membrane. A controller may activate a feedback device to inform an operator that the distal end of the shaft assembly has achieved suitable apposition with the tympanic membrane, based on information from the sensor.

公开(公告)号：US10987512B2

公开(公告)日：2021-04-27

申请号：US16194853

申请日：2018-11-19

申请人： Tusker Medical, Inc.

发明人： Mahyar Z. Kermani ,  Bernard H. Andreas ,  Rohit Girotra ,  Mansour A. Saleki ,  Nikhil D. Bhat

IPC分类号： A61N1/30 ,  A61F11/00 ,  A61N1/04 ,  A61N1/32 ,  A61N1/05

摘要： Various systems and methods provide iontophoretic delivery of anesthesia at a patient's tympanic membrane. Some implementations provide channel switching enabling a single current sink to pull current through two electrodes in an alternating fashion based on clock pulses. The iontophoretic delivery of anesthesia may be driven by an AC modulated current. Some implementations provide for continuous flow of fresh iontophoresis fluid to the ear canal during iontophoresis. The fluid flows from a source reservoir into the cavity between the tympanic membrane and a plug, and then drains out of the cavity to a reservoir. An iontophoresis system may also detect capacitance between an anode electrode and an auxiliary electrode in a patient's ear canal, watching for reduced capacitance to indicate presence of a bubble in the iontophoresis fluid.

公开(公告)号：US10219950B2

公开(公告)日：2019-03-05

申请号：US15090353

申请日：2016-04-04

申请人： Tusker Medical, Inc.

发明人： Bernard H. Andreas ,  Rohit Girotra ,  Jeffrey A. Walker ,  T. Daniel Gross ,  Mathew D. Clopp ,  Mahyar Z. Kermani ,  Scott J. Baron

IPC分类号： A61F11/00

摘要： A tympanostomy tube delivery device comprises a shaft assembly, a pressure equalization tube, and a sensor. The shaft assembly comprises a cannula and a pusher operable to translate relative to the cannula. The pressure equalization tube is positioned within the shaft assembly. The pusher is operable to drive the pressure equalization tube out of the shaft assembly. The sensor is operable to detect a physical parameter associated with engagement between the distal end of the shaft assembly and a tympanic membrane. A controller may activate a feedback device to inform an operator that the distal end of the shaft assembly has achieved suitable apposition with the tympanic membrane, based on information from the sensor.

公开(公告)号：US11839362B2

公开(公告)日：2023-12-12

申请号：US16961353

申请日：2019-01-15

申请人： TUSKER MEDICAL, INC.

发明人： Eric Goldfarb ,  Mahyar Z. Kermani ,  Rohit Girotra

IPC分类号： A61B1/227 ,  A61B1/00 ,  A61B1/018 ,  A61B1/04 ,  A61B1/05 ,  A61B1/06 ,  A61B1/07 ,  A61B1/32

CPC分类号： A61B1/227 ,  A61B1/0005 ,  A61B1/00006 ,  A61B1/0014 ,  A61B1/00048 ,  A61B1/00052 ,  A61B1/000094 ,  A61B1/018 ,  A61B1/042 ,  A61B1/05 ,  A61B1/0669 ,  A61B1/0684 ,  A61B1/07 ,  A61B1/32

摘要： Systems, apparatuses, and methods are described for providing visualization inside an ear of a subject before, during, or after an otologic procedure. An apparatus (100) includes a light source (140), a sensor (130), a processor (152, 170), and a display (154, 172, 972). The light source (140) can be configured to provide incident light to a target area (TM), and the sensor (130) can be configured to capture reflected light from the target area (TM) to generate image data based on the reflected light. The processor (152, 170) can process the image data to produce an image of the target area (TM), and the display (154, 172, 972) can display the image of the target area (TM).

公开(公告)号：US11759624B2

公开(公告)日：2023-09-19

申请号：US17183939

申请日：2021-02-24

申请人： TUSKER MEDICAL, INC.

发明人： Eric Goldfarb ,  Rohit Girotra ,  Mahyar Z. Kermani

IPC分类号： A61N1/04 ,  A61K9/00 ,  A61N1/05 ,  A61N1/30

CPC分类号： A61N1/0448 ,  A61K9/0009 ,  A61K9/0043 ,  A61N1/0436 ,  A61N1/0546 ,  A61N1/306

摘要： Systems, apparatus, and methods are described for delivering a therapeutic substance to a target area within or proximate to a nasal cavity of a subject, including a reservoir configured to contain the therapeutic substance and a delivery interface by which the therapeutic substance is delivered to the target area. In some embodiments, systems, apparatus, and methods described herein can deliver a therapeutic substance using iontophoresis and/or electroosmosis.

公开(公告)号：US11806493B2

公开(公告)日：2023-11-07

申请号：US16964773

申请日：2019-02-01

申请人： TUSKER MEDICAL, INC.

发明人： Eric Goldfarb ,  Mahyar Z. Kermani ,  Rohit Girotra

IPC分类号： A61F11/20 ,  A61M31/00

CPC分类号： A61M31/00 ,  A61M2205/0233 ,  A61M2205/35 ,  A61M2210/0668

摘要： Systems, apparatus, and methods are described for transporting and delivering a therapeutic substance to an ear of a subject, including a tubular element (216) configured for deployment in a tympanic membrane (TM) and a fluid transport element (230). The fluid transport element can be configured to transport the therapeutic substance from a proximal side to a distal side of the tubular element. Systems, apparatus, and methods further can include a fluid dispenser including a reservoir configured to contain a therapeutic substance, and a tubular element defining a lumen in fluid communication with an outlet in which the lumen and the outlet are configured to deliver the therapeutic substance from the reservoir to a region proximal to the tympanic membrane. Systems, apparatus, and methods further can include an electrode device.

公开(公告)号：US12011587B2

公开(公告)日：2024-06-18

申请号：US17190630

申请日：2021-03-03

申请人： TUSKER MEDICAL, INC.

发明人： Mahyar Z. Kermani ,  Bernard H. Andreas ,  Rohit Girotra ,  Mansour A. Saleki ,  Nikhil D. Bhat

IPC分类号： A61N1/30 ,  A61F11/00 ,  A61F11/20 ,  A61N1/04 ,  A61N1/32 ,  A61N1/05

CPC分类号： A61N1/30 ,  A61F11/00 ,  A61F11/202 ,  A61N1/0428 ,  A61N1/0472 ,  A61N1/303 ,  A61N1/325 ,  A61N1/0526 ,  A61N1/306

摘要： Various systems and methods provide iontophoretic delivery of anesthesia at a patient's tympanic membrane. At least one example is a method including: performing iontophoresis within a first ear canal by driving, by a control unit, a DC signal to an electrode of a first iontophoresis device positioned within the first ear canal, the electrode at least partially submerged within an iontophoresis fluid within the first ear canal; measuring, by the control unit, a mixed capacitance associated with the electrode by driving a first AC signal having a first frequency to the electrode; and determining, based on a change in the mixed capacitance, that an air bubble is present in the iontophoresis fluid.

公开(公告)号：US11806520B2

公开(公告)日：2023-11-07

申请号：US16754236

申请日：2018-10-30

申请人： TUSKER MEDICAL, INC.

发明人： Eric Goldfarb ,  Rohit Girotra ,  Mahyar Z. Kermani

IPC分类号： A61N1/04 ,  A61K9/00 ,  A61N1/05 ,  A61N1/30

CPC分类号： A61N1/0448 ,  A61K9/0009 ,  A61K9/0043 ,  A61N1/0436 ,  A61N1/0546 ,  A61N1/306

摘要： Systems, apparatus, and methods are described for delivering a therapeutic substance to a target area within or proximate to a nasal cavity of a subject, including a reservoir configured to contain the therapeutic substance and a delivery interface by which the therapeutic substance is delivered to the target area. In some embodiments, systems, apparatus, and methods described herein can deliver a therapeutic substance using iontophoresis and/or electroosmosis.

公开(公告)号：US10130808B2

公开(公告)日：2018-11-20

申请号：US13804491

申请日：2013-03-14

申请人： Tusker Medical, Inc.

发明人： Mahyar Z. Kermani ,  Bernard H. Andreas ,  Rohit Girotra ,  Mansour A. Saleki ,  Nikhil D. Bhat

IPC分类号： A61N1/30 ,  A61F11/00 ,  A61N1/32 ,  A61N1/04 ,  A61N1/05

摘要： Various systems and methods provide iontophoretic delivery of anesthesia at a patient's tympanic membrane. Some implementations provide channel switching enabling a single current sink to pull current through two electrodes in an alternating fashion based on clock pulses. The iontophoretic delivery of anesthesia may be driven by an AC modulated current. Some implementations provide for continuous flow of fresh iontophoresis fluid to the ear canal during iontophoresis. The fluid flows from a source reservoir into the cavity between the tympanic membrane and a plug, and then drains out of the cavity to a reservoir. An iontophoresis system may also detect capacitance between an anode electrode and an auxiliary electrode in a patient's ear canal, watching for reduced capacitance to indicate presence of a bubble in the iontophoresis fluid.