公开(公告)号：US20100249148A1

公开(公告)日：2010-09-30

申请号：US12815905

申请日：2010-06-15

申请人： Tadaaki OHGIYA ,  Toru MIURA ,  Ayumu OKUDA ,  Toshiharu ARAI ,  Koichi YAMAZAKI ,  Taro AOKI ,  Katsutoshi MIYOSAWA ,  Haruki SHIBATA ,  Kimiyuki SHIBUYA

发明人： Tadaaki OHGIYA ,  Toru MIURA ,  Ayumu OKUDA ,  Toshiharu ARAI ,  Koichi YAMAZAKI ,  Taro AOKI ,  Katsutoshi MIYOSAWA ,  Haruki SHIBATA ,  Kimiyuki SHIBUYA

IPC分类号： A61K31/506 ,  C07D401/12 ,  C07D471/04 ,  C07D403/12 ,  A61P9/10 ,  A61P3/06

CPC分类号： C07D401/12 ,  C07D403/12 ,  C07D471/04

摘要： A compound represented by the following general formula (I), wherein R1, R2, R3, R4 and R5 represent hydrogen atom, a halogen atom, a lower alkyl group and the like, R6 represents an alkyl group, a cycloalkyl group and the like, R7 and R8 represent hydrogen atom, a lower alkyl group, a (lower cycloalkyl)(lower alkyl) group and the like, R9 represents hydrogen atom, a halogen atom, a lower alkoxy group and the like, R10 and R11 represent hydrogen atom, a lower alkyl group, a lower alkoxy group, a halo(lower alkyl) group and the like, and A represents a heterocyclic ring constituted by 6 to 10 atoms, which has potent inhibitory activity on cholesterol ester transfer protein (CETP).

摘要翻译： 由下列通式（I）表示的化合物，其中R 1，R 2，R 3，R 4和R 5表示氢原子，卤原子，低级烷基等，R 6表示烷基，环烷基等 ，R7和R8表示氢原子，低级烷基，（低级环烷基）（低级烷基）等，R9表示氢原子，卤素原子，低级烷氧基等，R10和R11表示氢原子 ，低级烷基，低级烷氧基，卤代（低级烷基）等，A表示6〜10个原子构成的杂环，对胆固醇酯转移蛋白（CETP）具有有效的抑制活性。

公开(公告)号：US20090082352A1

公开(公告)日：2009-03-26

申请号：US12100831

申请日：2008-04-10

申请人： Tadaaki OHGIYA ,  Toru MIURA ,  Ayumu OKUDA ,  Toshiharu ARAI ,  Koichi YAMAZAKI ,  Taro AOKI ,  Katsutoshi MIYOSAWA ,  Haruki SHIBATA ,  Kimiyuki SHIBUYA

发明人： Tadaaki OHGIYA ,  Toru MIURA ,  Ayumu OKUDA ,  Toshiharu ARAI ,  Koichi YAMAZAKI ,  Taro AOKI ,  Katsutoshi MIYOSAWA ,  Haruki SHIBATA ,  Kimiyuki SHIBUYA

IPC分类号： A61K31/5377 ,  C07D239/42 ,  A61K31/505

CPC分类号： C07D239/42 ,  C07D239/47 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12

摘要： A compound represented by the following general formula (I), wherein R1, R2, R3, R4 and R5 represent hydrogen atom, a halo(lower alkyl) group, cyano group and the like, R6 represents an alkyl group, a cycloalkyl group and the like, R7, R8, R9 and R10 represent hydrogen atom, a halogen atom, a lower alkyl group, a halo(lower alkyl) group and the like, R11 and R12 represent hydrogen atom, a lower alkyl group, a (lower cycloalkyl) (lower alkyl) group and the like, and R13 represents hydrogen atom, a halogen atom, a lower alkoxy group and the like, which has potent inhibitory activity on cholesterol ester transfer protein (CETP).

摘要翻译： 由以下通式（I）表示的化合物，其中R 1，R 2，R 3，R 4和R 5表示氢原子，卤代（低级烷基）基，氰基等，R 6表示烷基，环烷基和 R 7，R 8，R 9和R 10表示氢原子，卤素原子，低级烷基，卤代（低级烷基）等，R 11和R 12表示氢原子，低级烷基，（低级环烷基 ）（低级烷基）等，R 13表示对胆固醇酯转移蛋白（CETP）具有强抑制活性的氢原子，卤素原子，低级烷氧基等。

公开(公告)号：US20090062306A1

公开(公告)日：2009-03-05

申请号：US12045982

申请日：2008-03-11

申请人： Tadaaki OHGIYA ,  Toru MIURA ,  Ayumu OKUDA ,  Toshiharu ARAI ,  Koichi YAMAZAKI ,  Taro AOKI ,  Katsutoshi MIYOSAWA ,  Haruki SHIBATA ,  Kimiyuki SHIBUYA

发明人： Tadaaki OHGIYA ,  Toru MIURA ,  Ayumu OKUDA ,  Toshiharu ARAI ,  Koichi YAMAZAKI ,  Taro AOKI ,  Katsutoshi MIYOSAWA ,  Haruki SHIBATA ,  Kimiyuki SHIBUYA

IPC分类号： A61K31/506 ,  C07D401/12 ,  C07D403/12

CPC分类号： C07D401/12 ,  C07D403/12 ,  C07D471/04

摘要： A compound represented by the following general formula (I), wherein R1, R2, R3, R4 and R5 represent hydrogen atom, a halogen atom, a lower alkyl group and the like, R6 represents an alkyl group, a cycloalkyl group and the like, R7 and R8 represent hydrogen atom, a lower alkyl group, a (lower cycloalkyl)(lower alkyl) group and the like, R9 represents hydrogen atom, a halogen atom, a lower alkoxy group and the like, R10 and R11 represent hydrogen atom, a lower alkyl group, a lower alkoxy group, a halo(lower alkyl) group and the like, and A represents a heterocyclic ring constituted by 6 to 10 atoms, which has potent inhibitory activity on cholesterol ester transfer protein (CETP).

摘要翻译： 由下列通式（I）表示的化合物，其中R 1，R 2，R 3，R 4和R 5表示氢原子，卤原子，低级烷基等，R 6表示烷基，环烷基等 ，R7和R8表示氢原子，低级烷基，（低级环烷基）（低级烷基）等，R9表示氢原子，卤素原子，低级烷氧基等，R10和R11表示氢原子 ，低级烷基，低级烷氧基，卤代（低级烷基）等，A表示6〜10个原子构成的杂环，对胆固醇酯转移蛋白（CETP）具有有效的抑制活性。

公开(公告)号：US20090054474A1

公开(公告)日：2009-02-26

申请号：US11835127

申请日：2007-08-07

申请人： Tadaaki OHGIYA ,  Toru MIURA ,  Ayumu OKUDA ,  Toshiharu ARAI ,  Koichi YAMAZAKI ,  Taro AOKI ,  Katsutoshi MIYOSAWA ,  Haruki SHIBATA ,  Kimiyuki SHIBUYA

发明人： Tadaaki OHGIYA ,  Toru MIURA ,  Ayumu OKUDA ,  Toshiharu ARAI ,  Koichi YAMAZAKI ,  Taro AOKI ,  Katsutoshi MIYOSAWA ,  Haruki SHIBATA ,  Kimiyuki SHIBUYA

IPC分类号： A61K31/506 ,  C07D401/12 ,  A61P3/04

CPC分类号： C07D401/12

摘要： A compound represented by the following general formula (I) or a salt thereof, or a solvate thereof: (wherein R1, R2, R3, R4 and R5 are the same or different, and represent hydrogen atom, a halogen atom, a lower alkyl group etc., R6, R7 and R8 are the same or different, and represent hydrogen atom, a halogen atom, a lower alkyl group etc., R9 and R10 are the same or different, and represent hydrogen atom, a lower alkyl group, a (lower cycloalkyl)(lower alkyl) group etc., and R11 represents hydrogen atom, a halogen atom, a lower alkoxy group, a (lower alkyl)thio(lower alkoxy) group, a (lower alkyl)sulfinyl(lower alkoxy) group, a (lower alkyl)sulfonyl(lower alkoxy) group etc.), which has potent inhibitory activity on CETP.

摘要翻译： 由下列通式（I）表示的化合物或其盐或其溶剂化物：（其中R1，R2，R3，R4和R5相同或不同，表示氢原子，卤素原子，低级烷基 基团等，R6，R7和R8相同或不同，表示氢原子，卤素原子，低级烷基等，R9和R10相同或不同，表示氢原子，低级烷基， （低级环烷基）（低级烷基）等，R11表示氢原子，卤素原子，低级烷氧基，（低级烷基）硫代（低级烷氧基），（低级烷基）亚磺酰基（低级烷氧基） 基团，（低级烷基）磺酰基（低级烷氧基）等），其对CETP具有有效的抑制活性。

公开(公告)号：US20090247587A1

公开(公告)日：2009-10-01

申请号：US12413894

申请日：2009-03-30

申请人： Ayumu OKUDA ,  Takayuki MATSUDA ,  Toru MIURA ,  Koichi YAMAZAKI ,  Yuki YAMAGUCHI ,  Minoru KOURA ,  Sayaka KUROBUCHI ,  Yuuichiro WATANABE ,  Kimiyuki SHIBUYA

发明人： Ayumu OKUDA ,  Takayuki MATSUDA ,  Toru MIURA ,  Koichi YAMAZAKI ,  Yuki YAMAGUCHI ,  Minoru KOURA ,  Sayaka KUROBUCHI ,  Yuuichiro WATANABE ,  Kimiyuki SHIBUYA

IPC分类号： A61K31/4178 ,  C07D405/12 ,  C07D405/14 ,  C07D417/14 ,  A61K31/4439 ,  A61K31/427 ,  A61P3/00 ,  A61P17/00 ,  A61P29/00 ,  A61P25/28

CPC分类号： C07D405/12 ,  C07D405/14 ,  C07D417/12 ,  C07D417/14

摘要： The object is to provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. The solving means is a 1,3-dihydroisobenzofuran derivative represented by the following general formula (1) or salt thereof, or their solvate.

摘要翻译： 目的是提供可用作动脉粥样硬化的预防和/或治疗剂的新型LXRβ激动剂; 动脉硬化，如糖尿病引起的; 血脂异常 高胆固醇血症 脂质相关疾病; 由炎性细胞因子引起的炎性疾病; 皮肤病如过敏性皮肤病; 糖尿病; 或阿尔茨海默病。 解决方法是由以下通式（1）表示的1,3-二氢异苯并呋喃衍生物或其盐或其溶剂合物。

公开(公告)号：US20090286780A1

公开(公告)日：2009-11-19

申请号：US12394548

申请日：2009-02-27

申请人： Ayumu OKUDA ,  Takayuki MATSUDA ,  Toru MIURA ,  Hidefumi OZAWA ,  Ayako TOSAKA ,  Koichi YAMAZAKI ,  Yuki YAMAGUCHI ,  Sayaka KUROBUCHI ,  Yuuichirou WATANABE ,  Kimiyuki SHIBUYA

发明人： Ayumu OKUDA ,  Takayuki MATSUDA ,  Toru MIURA ,  Hidefumi OZAWA ,  Ayako TOSAKA ,  Koichi YAMAZAKI ,  Yuki YAMAGUCHI ,  Sayaka KUROBUCHI ,  Yuuichirou WATANABE ,  Kimiyuki SHIBUYA

IPC分类号： A61K31/4178 ,  C07D407/12 ,  C07D413/14 ,  A61K31/5377 ,  A61P3/00 ,  A61P25/00 ,  A61P17/00

CPC分类号： C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12

摘要： To provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease.[Solving Means] A 2-oxochromene derivative represented by the following general formula (1) or salt thereof, or their solvate.

摘要翻译： 提供可用作动脉粥样硬化的预防和/或治疗剂的新型LXRβ激动剂; 动脉硬化，如糖尿病引起的; 血脂异常 高胆固醇血症 脂质相关疾病; 由炎性细胞因子引起的炎性疾病; 皮肤病如过敏性皮肤病; 糖尿病; 或阿尔茨海默病。 [解决方案]由以下通式（1）表示的2-氧代色烯衍生物或其盐或其溶剂合物。

公开(公告)号：US20170168418A1

公开(公告)日：2017-06-15

申请号：US15370817

申请日：2016-12-06

申请人： Nobuo TAKAMI ,  Tetsuro HIROTA ,  Kenji KIKUCHI ,  Koichi YAMAZAKI ,  Atsushi NAKAMOTO ,  Naohiro KAWASHIMA ,  Tatsuya KUBO ,  Shinnosuke KOSHIZUKA ,  Kazunori SUZUKI

发明人： Nobuo TAKAMI ,  Tetsuro HIROTA ,  Kenji KIKUCHI ,  Koichi YAMAZAKI ,  Atsushi NAKAMOTO ,  Naohiro KAWASHIMA ,  Tatsuya KUBO ,  Shinnosuke KOSHIZUKA ,  Kazunori SUZUKI

IPC分类号： G03G15/08

CPC分类号： G03G15/0856 ,  G03G15/0858 ,  G03G15/0865 ,  G03G15/0889

摘要： A powder supply device that includes a powder reservoir including a rotator having a rotation shaft, to store powder supplied from a powder container; and a powder amount detector. The powder amount detector includes a detected member disposed in the powder reservoir, a contact member attached to the rotation shaft, to contact the detected member to vibrate or move the detected member, a detector to detect vibration or a displacement of the detected member, and a detection result processor to detect the amount of the powder in the powder reservoir based on detection by the detector. The powder supply device further includes a controller to supply the powder from the powder container to the powder reservoir based on detection by the powder amount detector. The controller rotates the rotator in discharging the powder from the powder reservoir and supplying the powder from the powder container to the powder reservoir.

公开(公告)号：US20200292963A1

公开(公告)日：2020-09-17

申请号：US16799833

申请日：2020-02-25

申请人： Takahiro ADACHI ,  Koichi YAMAZAKI ,  Hideo YOSHIZAWA ,  Tatsuya OHHIRA

发明人： Takahiro ADACHI ,  Koichi YAMAZAKI ,  Hideo YOSHIZAWA ,  Tatsuya OHHIRA

IPC分类号： G03G15/08

摘要： A toner container includes a cylindrical container body having a head with an opening in the head, a cap into which the head of the container body is inserted, and a sheet member attached inside the cap. The cylindrical container body rotates around a rotation axis extending in a longitudinal direction of the container body to transport toner contained in the container body toward the opening. The cap has a toner outlet through which the toner discharged from the opening is discharged outside the toner container. The sheet member includes a first elastic-deformation portion that is elastically deformable and located near the toner outlet, and a second elastic-deformation portion that is elastically deformable and located in the container body and near the opening.

公开(公告)号：US20150063875A1

公开(公告)日：2015-03-05

申请号：US14465974

申请日：2014-08-22

申请人： Hironori OHSHIMA ,  Tadashi OGAWA ,  Koichi YAMAZAKI ,  Atsushi NAKAMOTO

发明人： Hironori OHSHIMA ,  Tadashi OGAWA ,  Koichi YAMAZAKI ,  Atsushi NAKAMOTO

IPC分类号： G03G15/08

CPC分类号： G03G15/0867 ,  G03G15/0872

摘要： A toner supplying device includes: a toner container that is tubular, includes a spiral groove at an outer circumferential face, a toner discharge opening at one end in a longitudinal direction, and a depression at the other end in the longitudinal direction, and is rotationally driven to convey toner contained in the toner container along the spiral groove in the longitudinal direction to discharge the toner from the toner discharge opening; a rotational driving unit that engages with the one end of the toner container to rotationally drive the toner container to cause the toner container to discharge the toner; and a projection provided at an interior portion at which the toner container is installed, and having an inclination in which a projection amount increases toward downstream in a rotational direction of the toner container. The projection is formed to fall in the depression of the toner container.

摘要翻译： 调色剂供给装置包括：管状的调色剂容器，包括外周面的螺旋槽，长度方向一端的调色剂排出口，长度方向的另一端的凹部，旋转地 被驱动以沿长度方向沿着螺旋槽输送容纳在调色剂容器中的调色剂以从调色剂排出口排出调色剂; 旋转驱动单元，其与所述调色剂容器的一端接合以旋转地驱动所述调色剂容器以使所述调色剂容器排出所述调色剂; 以及设置在调色剂容器安装的内部的凸起，并且具有突起量沿调色剂容器的旋转方向向下游增加的倾斜。 突起形成为落在调色剂容器的凹部中。

公开(公告)号：US20110127287A1

公开(公告)日：2011-06-02

申请号：US12955142

申请日：2010-11-29

申请人： Kazunori NAKAYA ,  Koichi YAMAZAKI ,  Hiroyuki ONO ,  Tatsuo ARAKAWA

发明人： Kazunori NAKAYA ,  Koichi YAMAZAKI ,  Hiroyuki ONO ,  Tatsuo ARAKAWA

IPC分类号： B65G59/00

CPC分类号： A47F1/126

摘要： An object is to provide an article advancing device and an article arrangement shelf that can be securely operated with a simple structure while not requiring electric power. An article advancing device of the present invention includes: an elongated drawer member 4 that includes a flexible band-shaped sheet and a stopper structure disposed at a distal end of the flexible band-shaped sheet, and is structured to allow articles Z, . . . to be arranged thereon when the elongated drawer member is held at a pulled-out position; a roller for fixing a proximal end of the band-shaped sheet in position and winding up the band-shaped sheet by a predetermined driving force while allowing the same to be freely pulled out; and a main body for housing the roller and the wound up band-shaped sheet, wherein the roller is provided in plural and disposed in parallel to each other within the main body, and the elongated drawer member and another elongated drawer member are disposed on the rollers respectively so as not to overlap each other in a width direction.

摘要翻译： 本发明的目的是提供一种可以在不需要电力的情况下以简单的结构可靠地操作的物品推进装置和物品排列架。 本发明的物品推进装置包括：细长的抽屉构件4，其包括柔性带状片和设置在柔性带状片的远端的止挡结构，并且构造成允许制品Z 1。 。 。 当细长的抽屉构件保持在拉出位置时被布置在其上; 用于将带状片材的基端固定就位并且通过预定的驱动力卷绕带状片材同时允许其自由拉出的辊子; 以及用于容纳所述辊和所述卷绕带状片的主体，其中所述辊设置在所述主体内并且彼此平行地设置，所述细长抽屉构件和另一细长抽屉构件设置在所述主体上 以使得不能在宽度方向上彼此重叠。