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    Process for preparing 1,2-diacyl-3-glycerylphosphorylcholines
    2.
    发明授权
    Process for preparing 1,2-diacyl-3-glycerylphosphorylcholines 失效
    制备1,2-二酰基-3-甘油基磷酰胆碱的方法

    公开(公告)号：US4130571A

    公开(公告)日：1978-12-19

    申请号：US652319

    申请日：1976-01-26

    申请人： Tadashi Nakajima ,  Yasuji Soda ,  Kenichi Kashima ,  Haruyoshi Kudoh ,  Akira Miyamoto

    发明人： Tadashi Nakajima ,  Yasuji Soda ,  Kenichi Kashima ,  Haruyoshi Kudoh ,  Akira Miyamoto

    IPC分类号： C07F9/10 ,  A23J7/00

    CPC分类号： C07F9/10

    摘要： Improved process for preparing 1,2-diacyl-3-glycerylphosphorylcholines, wherein the diacyl groups are, different or the same, a residue of a saturated or unsaturated fatty acid, particularly one of the acyl groups being a residue of a highly unsaturated fatty acid or being a residue of a saturated or unsaturated fatty acid labelled with an isotope, which comprises acylating a glyceryl-phosphorylcholine or monoacyl derivative thereof or the salt thereof with an acylating agent (e.g. 1-acylimidazole or 4-acyl-3-phenyl-1,2,4-oxadiazol-5-one) in the presence of a catalyst (e.g. an alkali salt of a nitrogen-containing 5-membered heterocyclic compound or sodium oxide).

    摘要翻译： 制备1,2-二酰基-3-甘油基磷酰胆碱的改进方法，其中二酰基是不同的或相同的，饱和或不饱和脂肪酸的残基，特别是一个酰基是高度不饱和脂肪酸的残基 或者是用同位素标记的饱和或不饱和脂肪酸的残基，该残基包括用酰化剂（例如1-酰基咪唑或4-酰基-3-苯基-1）酰化甘油基 - 磷酸胆碱或其一种酰基衍生物或其盐 ，2,4-恶二唑-5-酮）在催化剂（例如含氮5元杂环化合物或氧化钠的碱金属盐）存在下反应。

    Enzyme immunoassay for antigen and solid phase used therefor
    3.
    发明授权
    Enzyme immunoassay for antigen and solid phase used therefor 失效
    用于抗原和固相的酶免疫测定法

    公开(公告)号：US5378608A

    公开(公告)日：1995-01-03

    申请号：US542038

    申请日：1990-06-22

    申请人： Yoji Marui ,  Chozo Hayashi ,  Shigeki Ito ,  Mieko Fujio ,  Hiroki Tanaka ,  Toshihide Nagasaki ,  Yasuji Soda ,  Hitoshi Kaneta

    发明人： Yoji Marui ,  Chozo Hayashi ,  Shigeki Ito ,  Mieko Fujio ,  Hiroki Tanaka ,  Toshihide Nagasaki ,  Yasuji Soda ,  Hitoshi Kaneta

    IPC分类号： G01N33/53 ,  G01N33/543 ,  G01N33/547 ,  G01N33/563 ,  G01N33/574 ,  G01N33/58 ,  G01N33/68 ,  G01N33/537

    CPC分类号： G01N33/57473 ,  G01N33/54306 ,  G01N33/54353 ,  G01N33/57476 ,  G01N33/581 ,  G01N33/6878

    摘要： An enzyme immunoassay for an antigen using a solid phase, which employs (a) a biotinylated antibody in which a biotin derivative is bound to a thiol group of an Fab' fragment of an antibody, (b) an enzyme-labelled antibody, and (c) a solid phase immobilized with a substance capable of specifically reacting with the above biotin derivative selected from the group consisting of avidin, streptoavidin and a derivative thereof which is bound to the solid phase directly or via a linkage between another biotin derivative and a high molecular weight substance bound to the solid phase, or alternatively employs (a') a solid phase immobilized with a biotinylated antibody via a substance selected from the group consisting of avidin, streptoavidin and a derivative thereof wherein said substance is bound to the biotin moiety of said biotinylated antibody and is also bound to the solid phase directly or via a linkage between another biotin derivative and a high molecular weight substance bound to the solid phase, and (b') an enzyme-labelled antibody, and a solid phase used therefor.

    摘要翻译： 对于使用固相的抗原的酶免疫测定法，其使用（a）生物素化抗体，其中生物素衍生物与抗体的Fab'片段的硫醇基团结合，（b）酶标记的抗体和（ c）固定有与能够与上述生物素衍生物特异性反应的物质的固相，所述物质选自抗生物素蛋白，链霉亲和素及其衍生物，其直接或通过另一生物素衍生物与高 或者通过选自抗生物素蛋白，链霉抗生物素及其衍生物的物质（a'）固定有生物素化抗体的固相，其中所述物质与生物素部分结合， 所述生物素化抗体也直接或通过另一种生物素衍生物与结合至 固相和（b'）酶标记的抗体，以及用于其的固相。