公开(公告)号：US4130571A

公开(公告)日：1978-12-19

申请号：US652319

申请日：1976-01-26

申请人： Tadashi Nakajima ,  Yasuji Soda ,  Kenichi Kashima ,  Haruyoshi Kudoh ,  Akira Miyamoto

发明人： Tadashi Nakajima ,  Yasuji Soda ,  Kenichi Kashima ,  Haruyoshi Kudoh ,  Akira Miyamoto

IPC分类号： C07F9/10 ,  A23J7/00

CPC分类号： C07F9/10

摘要： Improved process for preparing 1,2-diacyl-3-glycerylphosphorylcholines, wherein the diacyl groups are, different or the same, a residue of a saturated or unsaturated fatty acid, particularly one of the acyl groups being a residue of a highly unsaturated fatty acid or being a residue of a saturated or unsaturated fatty acid labelled with an isotope, which comprises acylating a glyceryl-phosphorylcholine or monoacyl derivative thereof or the salt thereof with an acylating agent (e.g. 1-acylimidazole or 4-acyl-3-phenyl-1,2,4-oxadiazol-5-one) in the presence of a catalyst (e.g. an alkali salt of a nitrogen-containing 5-membered heterocyclic compound or sodium oxide).

摘要翻译： 制备1,2-二酰基-3-甘油基磷酰胆碱的改进方法，其中二酰基是不同的或相同的，饱和或不饱和脂肪酸的残基，特别是一个酰基是高度不饱和脂肪酸的残基 或者是用同位素标记的饱和或不饱和脂肪酸的残基，该残基包括用酰化剂（例如1-酰基咪唑或4-酰基-3-苯基-1）酰化甘油基 - 磷酸胆碱或其一种酰基衍生物或其盐 ，2,4-恶二唑-5-酮）在催化剂（例如含氮5元杂环化合物或氧化钠的碱金属盐）存在下反应。

公开(公告)号：US4263286A

公开(公告)日：1981-04-21

申请号：US146215

申请日：1980-05-05

申请人： Tadashi Nakajima ,  Kyoji Rikimi ,  Yasuji Soda ,  Kenichi Kashima ,  Akira Miyamoto ,  Yoshikazu Soejima

发明人： Tadashi Nakajima ,  Kyoji Rikimi ,  Yasuji Soda ,  Kenichi Kashima ,  Akira Miyamoto ,  Yoshikazu Soejima

IPC分类号： A61K31/685 ,  A61K31/66 ,  A61P25/02 ,  A61P25/28 ,  A23J7/00

CPC分类号： A61K31/685 ,  A61K31/66

摘要： A therapeutic agent for treating consciousness disorder and perception and movement which comprises as an essential active ingredient a phosphatidic acid derivative selected from a phosphatidylcholine, a phosphatidic acid and a phosphatidylethanolamine in admixture with a conventional carrier. Said agent is administered to the patient suffered from consciousness disorder and perception and movement disorder, particularly the post-traumatic syndrome of the head injury and the sequelae of apoplexy or whiplash injury in oral or parenteral route, preferably in an intravenous route.

摘要翻译： 用于治疗意识障碍和感知和运动的治疗剂，其包含与常规载体混合的选自磷脂酰胆碱，磷脂酸和磷脂酰乙醇胺的磷脂酸衍生物作为必需活性成分。 对患有意识障碍和感觉和运动障碍的患者，特别是头部损伤的创伤后综合征和口服或肠胃外途径的中风或鞭打损伤的后遗症，优选静脉内途径给予所述药剂。

公开(公告)号：US20150047010A1

公开(公告)日：2015-02-12

申请号：US14380693

申请日：2013-02-01

申请人： Yoshiya Kizu ,  Kenichi Kashima

发明人： Yoshiya Kizu ,  Kenichi Kashima

IPC分类号： H04L29/06 ,  H04L12/803

CPC分类号： H04L63/0227 ,  H04L45/125 ,  H04L45/64 ,  H04L47/122 ,  H04L63/0209 ,  H04L63/164 ,  H04L67/322 ,  H04L69/14

摘要： To provide a path control system, a control device and a path control method that can achieve reduction of the load on a gateway device, there are included a communication device, a communication device, a security device that provides a security feature to data transmitted and received between the communication device and the communication device, and a path control device that selects one of a first path through the security device and a second path not through the security device as a communication path of the data based on a path information table where an attribute of the data and a communication path between the communication device and the communication device are associated.

摘要翻译： 为了提供可以实现网关设备上的负载减小的路径控制系统，控制设备和路径控制方法，包括通信设备，通信设备，为传输的数据提供安全特征的安全设备，以及 在通信装置和通信装置之间接收的路径控制装置，以及路径控制装置，其基于路径信息表选择通过安全装置的第一路径和不通过安全装置的第二路径作为数据的通信路径，其中， 数据的属性和通信设备与通信设备之间的通信路径相关联。

公开(公告)号：US10038669B2

公开(公告)日：2018-07-31

申请号：US14380693

申请日：2013-02-01

申请人： Yoshiya Kizu ,  Kenichi Kashima

发明人： Yoshiya Kizu ,  Kenichi Kashima

IPC分类号： G06F9/00 ,  H04L29/06 ,  H04L29/08 ,  H04L12/803 ,  H04L12/715 ,  H04L12/729

CPC分类号： H04L63/0227 ,  H04L45/125 ,  H04L45/64 ,  H04L47/122 ,  H04L63/0209 ,  H04L63/164 ,  H04L67/322 ,  H04L69/14

摘要： To provide a path control system, a control device and a path control method that can achieve reduction of the load on a gateway device, there are included a communication device, a communication device, a security device that provides a security feature to data transmitted and received between the communication device and the communication device, and a path control device that selects one of a first path through the security device and a second path not through the security device as a communication path of the data based on a path information table where an attribute of the data and a communication path between the communication device and the communication device are associated.

公开(公告)号：US20060048753A1

公开(公告)日：2006-03-09

申请号：US11218709

申请日：2005-09-06

申请人： Kenichi Kashima

发明人： Kenichi Kashima

IPC分类号： F02M61/14

CPC分类号： F02M61/145

摘要： A fuel supply apparatus is provided for an intake manifold and a fuel injection system that can be easily and reliably mounted together by a mounting structure, even when the intake manifold has an integrated design in which air intake branches curve steeply upward from a downward side to an upstream side. With this fuel supply apparatus, the fuel injection system is mounted with coupling bolts on the top surface of the outer wall of the downstream portion of the intake manifold. The threads of the bolts engage internal threaded bores in the fuel injection system. The heads of the bolts are disposed on a reverse side of a top surface of an outer wall of the intake manifold, with internal threaded bores of the fuel injection system being disposed on a side of the top surface of the outer wall of the intake manifold.

摘要翻译： 一种用于进气歧管和燃料喷射系统的燃料供给装置，其能够通过安装结构容易且可靠地安装在一起，即使当进气歧管具有一体式设计时，进气歧管从下侧向下倾斜向上弯曲， 上游侧 利用该燃料供给装置，燃料喷射系统在进气歧管的下游部分的外壁的顶表面上安装有联接螺栓。 螺栓的螺纹与燃油喷射系统中的内螺纹孔接合。 螺栓的头部设置在进气歧管的外壁的顶表面的相反侧上，燃料喷射系统的内螺纹孔设置在进气歧管的外壁的顶表面的一侧 。

公开(公告)号：US5716950A

公开(公告)日：1998-02-10

申请号：US530100

申请日：1995-11-20

申请人： Kenichi Kashima ,  Yoshinobu Akimoto ,  Yasuhiko Sakamoto ,  Hirohiko Sakamoto ,  Kayo Yokode ,  Toshimi Sakurai ,  Takeshi Takeno ,  Shigetaka Takemura ,  Hiroichi Nagai

发明人： Kenichi Kashima ,  Yoshinobu Akimoto ,  Yasuhiko Sakamoto ,  Hirohiko Sakamoto ,  Kayo Yokode ,  Toshimi Sakurai ,  Takeshi Takeno ,  Shigetaka Takemura ,  Hiroichi Nagai

IPC分类号： C07D213/38 ,  C07D295/088 ,  A61K31/55 ,  A61K31/495 ,  C07D295/12 ,  C07D401/06

CPC分类号： C07D295/088 ,  C07D213/38 ,  C07C2101/02 ,  C07C2101/04 ,  C07C2101/08 ,  C07C2101/14

摘要： A diazacycloalkanealkylsulfonamide derivative having the following formula �I!: ##STR1## and pharmacologically acceptable salts thereof. The compounds have antiallergic activity with low antihistaminic activity and low toxicity and are useful as an medicament for preventing and treating diseases such as bronchial asthma, allergic rhinitis, atopic dermatitis, urticaria.

摘要翻译： PCT No.PCT / JP95 / 00008 Sec。 371日期：1995年11月20日 102（e）1995年11月20日日期PCT 1995年1月9日PCT PCT。 WO95 / 19345 PCT公开号 日期1995年7月20日具有下式[I]的二氮杂环烷烷基磺酰胺衍生物及其药理学上可接受的盐。 该化合物具有抗过敏活性，抗组氨酸活性低，毒性低，可用作预防和治疗诸如支气管哮喘，过敏性鼻炎，特应性皮炎，荨麻疹等疾病的药物。

公开(公告)号：US07191763B2

公开(公告)日：2007-03-20

申请号：US11218709

申请日：2005-09-06

申请人： Kenichi Kashima

发明人： Kenichi Kashima

IPC分类号： F02M61/14

CPC分类号： F02M61/145

摘要： A fuel supply apparatus is provided for an intake manifold and a fuel injection system that can be easily and reliably mounted together by a mounting structure, even when the intake manifold has an integrated design in which air intake branches curve steeply upward from a downward side to an upstream side. With this fuel supply apparatus, the fuel injection system is mounted with coupling bolts on the top surface of the outer wall of the downstream portion of the intake manifold. The threads of the bolts engage internal threaded bores in the fuel injection system. The heads of the bolts are disposed on a reverse side of a top surface of an outer wall of the intake manifold, with internal threaded bores of the fuel injection system being disposed on a side of the top surface of the outer wall of the intake manifold.

摘要翻译： 一种用于进气歧管和燃料喷射系统的燃料供给装置，其能够通过安装结构容易且可靠地安装在一起，即使当进气歧管具有一体式设计时，进气歧管从下侧向下倾斜向上弯曲， 上游侧 利用该燃料供给装置，燃料喷射系统在进气歧管的下游部分的外壁的顶表面上安装有联接螺栓。 螺栓的螺纹与燃油喷射系统中的内螺纹孔接合。 螺栓的头部设置在进气歧管的外壁的顶表面的相反侧上，燃料喷射系统的内螺纹孔设置在进气歧管的外壁的顶表面的一侧 。

公开(公告)号：US06172228B2

公开(公告)日：2001-01-09

申请号：US09453223

申请日：1999-12-03

申请人： Kenichi Kashima ,  Yasuhiko Sakamoto ,  Yoichiro Ohta ,  Kenji Kawanishi ,  Shigetaka Takemura ,  Yasuko Takemura

发明人： Kenichi Kashima ,  Yasuhiko Sakamoto ,  Yoichiro Ohta ,  Kenji Kawanishi ,  Shigetaka Takemura ,  Yasuko Takemura

IPC分类号： C07D40106

CPC分类号： C07D295/088 ,  C07D213/38

摘要： A process for advantageously preparing a piperazinesulfonamide derivative represented by the general formula (III): wherein R1 is hydrogen atom, a straight or branched chain alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, a halogen atom, hydroxyl group, trifluoromethyl group, nitro group or amino group; R2 is a phenyl group which may have as substituents on its phenyl ring 1 to 3 groups selected from the group consisting of an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, a halogen atom, hydroxyl group, trifluoromethyl group, nitro group and amino group, 2-pyridyl group, 3-pyridyl group or 4-pyridyl group; each of R3 and R4 is independently hydrogen atom, a straight or branched chain alkyl group having 1 to 6 carbon atoms, a hydroxyalkyl group having 1 to 4 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, or a phenyl group which may be substituted; and Y is an alkylene group having 1 to 12 carbon atoms, and a salt thereof.

摘要翻译： 一种有利地制备由通式（III）表示的哌嗪磺酰胺衍生物的方法：其中R1是氢原子，具有1至6个碳原子的直链或支链烷基，具有1至4个碳原子的烷氧基，卤素原子 ，羟基，三氟甲基，硝基或氨基; R2是可以在其苯环上具有取代基的苯基，其选自具有1至4个碳原子的烷基，具有1至4个碳原子的烷氧基，卤素原子，羟基 三氟甲基，硝基和氨基，2-吡啶基，3-吡啶基或4-吡啶基; R 3和R 4各自独立地为氢原子，具有1至6个碳原子的直链或支链烷基，具有1至4个碳原子的羟基烷基，具有3至8个碳原子的环烷基或苯基， 被替代 Y为碳原子数1〜12的亚烷基及其盐。

公开(公告)号：US4874773A

公开(公告)日：1989-10-17

申请号：US239005

申请日：1988-08-30

申请人： Masakatu Hisaki ,  Kenichi Kashima ,  Yasuhiko Sakamoto ,  Masakazu Hojo ,  Osamu Katayama ,  Hiroyoshi Hata

发明人： Masakatu Hisaki ,  Kenichi Kashima ,  Yasuhiko Sakamoto ,  Masakazu Hojo ,  Osamu Katayama ,  Hiroyoshi Hata

IPC分类号： A61K31/455 ,  A61P9/00 ,  A61P9/06 ,  A61P9/08 ,  A61P9/12 ,  C07D211/90

CPC分类号： C07D211/90

摘要： Novel 3-aminocarbonyl-1,4-dihydropyridine-5-carboxylic acid compounds of the formula: ##STR1## wherein R.sup.1 is H, C.sub.1-5 alkyl, C.sub.2-5 alkenyl, C.sub.3.5 alkynyl, C.sub.3-8 cycloalkyl, R.sup.2 is C.sub.1-10 alkyl, and the NO.sub.2 group is substituted at ortho- or meta-position, provided that when the NO.sub.2 group is substituted at ortho-position and R.sup.2 is methyl, R.sup.1 is C.sub.3-5 alkyl, C.sub.2-5 alkenyl, C.sub.3-5 alkynyl, or C.sub.3-8 cycloalkyl, and when the NO.sub.2 group is substituted at meta-position and R.sup.1 is H, R.sup.2 is C.sub.3-10 alkyl, which have excellent hypotensive, vasodilating activities and are useful for the prophylaxis and treatment of hypertension, ischemic heart diseases and cerebral and peripheral circulation diseases.

摘要翻译： 新颖的下式的3-氨基羰基-1,4-二氢吡啶-5-羧酸化合物：其中R 1是H，C 1-5烷基，C 2-5烯基，C 3-5炔基，C 3-8环烷基 R2是C1-10烷基，并且NO2基团在邻位或间位被取代，条件是当NO 2基团在邻位被取代且R2是甲基时，R1是C3-5烷基，C2-5烯基 ，C3-5炔基或C3-8环烷基，当NO2基团在间位被取代且R1为H时，R2为C3-10烷基，具有优异的降血压，血管舒张活性，可用于预防和治疗 的高血压，缺血性心脏病和脑和周围循环疾病。