Method for manufacture of N-formylaspartic anhydride
    1.
    发明授权
    Method for manufacture of N-formylaspartic anhydride 失效
    N-甲酰基天冬氨酸酐的制备方法

    公开(公告)号:US4550180A

    公开(公告)日:1985-10-29

    申请号:US589685

    申请日:1984-03-15

    CPC分类号: C07D307/66

    摘要: In a method for the manufacture of N-formylaspartic acid anhydride which comprises reacting a mixture of aspartic acid, formic acid and acetic anhydride in the presence of an entraining organic solvent, the improvement comprising adding to the mixture, prior to or during the course of reaction, an oxide, hydroxide, or a salt of a metal. The above compound is used as an intermediate in the manufacture of alpha-L-aspartyl-L-phenylalanine methyl ester which is a sweetening agent.

    摘要翻译: 在制备N-甲酰基天冬氨酸酐的方法中,其包括在夹带有机溶剂的存在下使天冬氨酸,甲酸和乙酸酐的混合物反应,其改进包括在混合物之前或期间 反应,氧化物,氢氧化物或金属的盐。 上述化合物用作制造作为甜味剂的α-L-天冬氨酰基-L-苯丙氨酸甲酯的中间体。

    Process for producing N-carbobenzoxy-L-aspartic anhydride
    3.
    发明授权
    Process for producing N-carbobenzoxy-L-aspartic anhydride 失效
    制备N-苄氧羰基-L-天冬氨酸酐的方法

    公开(公告)号:US4508912A

    公开(公告)日:1985-04-02

    申请号:US479898

    申请日:1983-03-29

    IPC分类号: C07D307/66

    CPC分类号: C07D307/66

    摘要: A process for producing a high yield of N-carbobenzoxy-L-aspartic anhydride from N-carbobenzoxy-L-aspartic acid in a very short period using commercially acceptable reaction conditions is disclosed. The process is characterized by reacting N-carbobenzoxy-L-aspartic acid with acetic anhydride in the presence of a metal oxide, a metal hydroxide, a metal salt of acid, an organobasic compound or an acid having a dissociation constant of 5.times.10.sup.-2 or more.

    摘要翻译: 公开了一种在非常短的时间内使用商业上可接受的反应条件从N-苄氧羰基-L-天冬氨酸生产N-苄氧羰基-L-天冬氨酸高产率的方法。 该方法的特征在于N-烷氧羰基-L-天冬氨酸与乙酸酐在金属氧化物,金属氢氧化物,酸金属盐,有机碱化合物或解离常数为5×10 -2的酸的存在下反应,或 更多。