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公开(公告)号：US20100240685A1
公开(公告)日：2010-09-23
申请号：US12679893
申请日：2008-09-24
IPC分类号： A61K31/505 , C07D239/38 , A61P27/14 , A61P29/00 , A61P35/02 , A61P19/02 , A61P1/00 , A61P11/06
CPC分类号： C07D239/47
摘要： Provided herein are 2-S-benzyl pyrimidine compounds having CRTH2 (G-protein-coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity, useful for the prophylaxis and treatment of diseases associated with CRTH2 activity, including the treatment of allergic diseases, eosinophil-related diseases and basophil-related diseases.
摘要翻译： 本文提供了具有CRTH2（G蛋白偶联化学引诱物受体，Th2细胞表达）拮抗活性的2-S-苄基嘧啶化合物，可用于预防和治疗与CRTH2活性相关的疾病，包括治疗过敏性疾病，嗜酸性粒细胞 相关疾病和嗜碱性粒细胞相关疾病。
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公开(公告)号：US08324229B2
公开(公告)日：2012-12-04
申请号：US12679895
申请日：2008-09-24
IPC分类号： C07D239/38 , C07D239/47 , A61K31/505
CPC分类号： C07D239/38 , C07D239/47 , C07D239/58 , C07D403/12
摘要： Provided herein are alkylthio substituted pyrimidine compounds having CRTH2 (G-protein-coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity, useful for the treatment or prophylaxis of diseases associated with CRTH2 activity, including the treatment of allergic diseases, eosinophil-related diseases and basophil-related diseases.
摘要翻译： 本文提供了具有CRTH2（在Th2细胞上表达的G蛋白偶联化学引诱物受体）拮抗活性的烷硫基取代的嘧啶化合物，其可用于治疗或预防与CRTH2活性相关的疾病，包括治疗过敏性疾病，嗜酸性粒细胞相关疾病 和嗜碱性粒细胞相关疾病。
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公开(公告)号：US20100273782A1
公开(公告)日：2010-10-28
申请号：US12764900
申请日：2010-04-21
IPC分类号： A61K31/445 , C07D211/58 , C07D295/14 , C07D243/08 , C07D401/04 , C07D487/04 , A61K31/495 , A61K31/551 , A61K31/5375 , A61K31/4468 , A61K31/454 , A61K31/277 , A61K31/54 , A61P11/06 , A61P29/00 , A61P11/00 , A61P19/02 , A61P9/00
CPC分类号： C07D487/04 , C07C311/29 , C07C323/67 , C07D211/96 , C07D241/04 , C07D243/08 , C07D295/26 , C07D403/04
摘要： Provided herein are 2,5-disubstituted arylsulfonamides that are useful for modulating CCR3 activity, and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a CCR3-mediated disorder, disease, or condition.
摘要翻译： 本文提供了可用于调节CCR3活性的2,5-二取代的芳基磺酰胺及其药物组合物。 本文还提供其用于治疗，预防或改善CCR3介导的病症，疾病或病症的一种或多种症状的方法。
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公开(公告)号：US08669247B2
公开(公告)日：2014-03-11
申请号：US13846222
申请日：2013-03-18
IPC分类号： A61K31/551 , A61K31/445 , A61K31/497 , A61K31/4965
CPC分类号： C07D487/04 , C07C311/29 , C07C323/67 , C07D211/96 , C07D241/04 , C07D243/08 , C07D295/26 , C07D403/04
摘要： Provided herein are 2,5-disubstituted arylsulfonamides that are useful for modulating CCR3 activity, and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a CCR3-mediated disorder, disease, or condition.
摘要翻译： 本文提供了可用于调节CCR3活性的2,5-二取代的芳基磺酰胺及其药物组合物。 本文还提供其用于治疗，预防或改善CCR3介导的病症，疾病或病症的一种或多种症状的方法。
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公开(公告)号：US08399456B2
公开(公告)日：2013-03-19
申请号：US12764900
申请日：2010-04-21
IPC分类号： A61K31/551 , A61K31/445 , A61K31/495 , A61K31/5375 , A61K31/4468 , A61K31/454 , A61K31/277 , C07D211/58 , C07D295/14 , C07D243/08 , C07D401/04 , C07D487/04
CPC分类号： C07D487/04 , C07C311/29 , C07C323/67 , C07D211/96 , C07D241/04 , C07D243/08 , C07D295/26 , C07D403/04
摘要： Provided herein are 2,5-disubstituted arylsulfonamides that are useful for modulating CCR3 activity, and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a CCR3-mediated disorder, disease, or condition.
摘要翻译： 本文提供了可用于调节CCR3活性的2,5-二取代的芳基磺酰胺及其药物组合物。 本文还提供其用于治疗，预防或改善CCR3介导的病症，疾病或病症的一种或多种症状的方法。
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公开(公告)号：US08314116B2
公开(公告)日：2012-11-20
申请号：US12679893
申请日：2008-09-24
IPC分类号： C07D239/47 , A61K31/505
CPC分类号： C07D239/47
摘要： Provided herein are 2-S-benzyl pyrimidine compounds having CRTH2 (G-protein-coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity, useful for the prophylaxis and treatment of diseases associated with CRTH2 activity, including the treatment of allergic diseases, eosinophil-related diseases and basophil-related diseases.
摘要翻译： 本文提供了具有CRTH2（G蛋白偶联化学引诱物受体，Th2细胞表达）拮抗活性的2-S-苄基嘧啶化合物，可用于预防和治疗与CRTH2活性相关的疾病，包括治疗过敏性疾病，嗜酸性粒细胞 相关疾病和嗜碱性粒细胞相关疾病。
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