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公开(公告)号:US09480678B2
公开(公告)日:2016-11-01
申请号:US12676331
申请日:2008-09-05
IPC分类号: A61K31/385 , A61K31/4164 , A61K31/4178 , A61K9/00 , A61K47/10 , A61K47/38
CPC分类号: A61K31/4178 , A61K9/0014 , A61K9/08 , A61K31/385 , A61K31/4164 , A61K47/10 , A61K47/38
摘要: Disclosed is an antifungal agent for external use, which is characterized by containing a compound represented by the general formula (1), 50 to 95 mass % of an alcohol such as ethanol, 0.1 to 35 mass % of water or the like, and 0.01 to 5 mass % of a cellulose thickening agent. X is a halogen or H.
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公开(公告)号:US08513296B2
公开(公告)日:2013-08-20
申请号:US13603220
申请日:2012-09-04
IPC分类号: A61K31/4178 , A61P31/10
CPC分类号: A61K9/0014 , A61K31/4178
摘要: Disclosed is an antifungal agent for external use, which is characterized by containing a compound represented by the general formula (1) below, 50-95% by mass of an alcohol, and 0.1-35% by mass of water and/or an anionic surfactant.
摘要翻译: 公开了一种外用抗真菌剂,其特征在于,含有下述通式(1)表示的化合物,50-95质量%的醇和0.1-35质量%的水和/或阴离子 表面活性剂。
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公开(公告)号:US20120329845A1
公开(公告)日:2012-12-27
申请号:US13603220
申请日:2012-09-04
IPC分类号: A61K31/4178 , A61P31/10
CPC分类号: A61K9/0014 , A61K31/4178
摘要: Disclosed is an antifungal agent for external use, which is characterized by containing a compound represented by the general formula (1) below, 50-95% by mass of an alcohol, and 0.1-35% by mass of water and/or an anionic surfactant.
摘要翻译: 公开了一种外用抗真菌剂,其特征在于含有下述通式(1)表示的化合物,50-95质量%的醇和0.1-35质量%的水和/或阴离子 表面活性剂。
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公开(公告)号:US20100204293A1
公开(公告)日:2010-08-12
申请号:US12676346
申请日:2008-09-05
IPC分类号: A61K31/4178 , A61P31/10
CPC分类号: A61K9/0014 , A61K31/4178
摘要: Disclosed is an antifungal agent for external use, which is characterized by containing a compound represented by the general formula (1) below, 50-95% by mass of an alcohol, and 0.1-35% by mass of water and/or an anionic surfactant.
摘要翻译: 公开了一种外用抗真菌剂,其特征在于,含有下述通式(1)表示的化合物,50-95质量%的醇和0.1-35质量%的水和/或阴离子 表面活性剂。
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公开(公告)号:US20100173965A1
公开(公告)日:2010-07-08
申请号:US12676345
申请日:2008-09-05
CPC分类号: A61K31/4178 , A61K9/0014 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/22 , A61K47/26 , A61K47/32 , A61K47/34
摘要: Disclosed is a pharmaceutical composition for antifungal use, comprising: 1) one or more compounds selected from compounds represented by the general formula (1) below and physiologically acceptable salts thereof; 2) one or more compounds selected from polypropylene glycol, diesters of dibasic acids, triacetin, 2-ethyl-1,3-hexanediol, lauromacrogol, and polyoxyethylene-polyoxypropylene glycol; and 3) one or more compounds selected from glucono-δ-lactone, propylene glycol, glycerin, and lactic acid. General formula (1) (In the formula, X represents a halogen or hydrogen). wherein X represents a halogen or hydrogen.
摘要翻译: 公开了一种用于抗真菌用途的药物组合物,包括:1)一种或多种选自下述通式(1)的化合物及其生理学可接受的盐; 2)一种或多种选自聚丙二醇,二元酸二酯,三醋精,2-乙基-1,3-己二醇,月桂醇和聚氧乙烯 - 聚氧丙烯二醇的化合物; 和3)一种或多种选自葡萄糖酸-δ-内酯,丙二醇,甘油和乳酸的化合物。 通式(1)(式中,X表示卤素或氢)。 其中X表示卤素或氢。
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公开(公告)号:US20100168200A1
公开(公告)日:2010-07-01
申请号:US12676331
申请日:2008-09-05
CPC分类号: A61K31/4178 , A61K9/0014 , A61K9/08 , A61K31/385 , A61K31/4164 , A61K47/10 , A61K47/38
摘要: Disclosed is an antifungal agent for external use, which is characterized by containing a compound represented by the general formula (1), 50 to 95 mass % of an alcohol such as ethanol, 0.1 to 35 mass % of water or the like, and 0.01 to 5 mass % of a cellulose thickening agent. X is a halogen or H.
摘要翻译: 公开了一种外用抗真菌剂,其特征在于,含有通式(1)表示的化合物,50〜95质量%的醇如乙醇,0.1〜35质量%的水等,0.01 至5质量%的纤维素增稠剂。 X是卤素或H.
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公开(公告)号:US20050232879A1
公开(公告)日:2005-10-20
申请号:US10518776
申请日:2003-06-10
申请人: Hideaki Sasagawa , Madoka Ito , Takuji Nakashima , Akira Nozawa
发明人: Hideaki Sasagawa , Madoka Ito , Takuji Nakashima , Akira Nozawa
CPC分类号: A61K47/10 , A61K9/7015 , A61K31/4178 , A61K47/38
摘要: An object of the present invention is to provide a medicinal composition useful for external application in the treatment of a fungal infection reaching the lower part of a thick keratin layer. Provided is an antifungal medicinal composition, comprising: (1) a film-forming agent; (2) a water-soluble plasticizer in a form of a solid or a paste at 20° C. at 1 atm; and (3) an antifungal compound represented by a general formula (1) and/or a physiologically acceptable salt thereof.
摘要翻译: 本发明的目的是提供一种可用于外用于治疗到达厚角蛋白层下部的真菌感染的药物组合物。 提供一种抗真菌药用组合物,其包含:(1)成膜剂; (2)在20℃,1atm下固体或糊状形式的水溶性增塑剂; 和(3)由通式(1)表示的抗真菌化合物和/或其生理学上可接受的盐。
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公开(公告)号:US08741941B2
公开(公告)日:2014-06-03
申请号:US13240833
申请日:2011-09-22
申请人: Hideaki Sasagawa , Madoka Ito , Takuji Nakashima , Akira Nozawa
发明人: Hideaki Sasagawa , Madoka Ito , Takuji Nakashima , Akira Nozawa
IPC分类号: A01N43/50 , A61K31/415 , A01N43/26 , A61K31/385 , A61F13/00 , A61K9/70
CPC分类号: A61K47/10 , A61K9/7015 , A61K31/4178 , A61K47/38
摘要: An object of the present invention is to provide a medicinal composition useful for external application in the treatment of a fungal infection reaching the lower part of a thick keratin layer. Provided is an antifungal medicinal composition, comprising: (1) a film-forming agent; (2) a water-soluble plasticizer in a form of a solid or a paste at 20° C. at 1 atm; and (3) an antifungal compound represented by a general formula (1) and/or a physiologically acceptable salt thereof.
摘要翻译: 本发明的目的是提供一种可用于外用于治疗到达厚角蛋白层下部的真菌感染的药物组合物。 提供一种抗真菌药用组合物,其包含:(1)成膜剂; (2)在20℃,1atm下固体或糊状形式的水溶性增塑剂; 和(3)由通式(1)表示的抗真菌化合物和/或其生理学上可接受的盐。
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公开(公告)号:US20120015996A1
公开(公告)日:2012-01-19
申请号:US13240833
申请日:2011-09-22
申请人: Hideaki Sasagawa , Madoka Ito , Takuji Nakashima , Akira Nozawa
发明人: Hideaki Sasagawa , Madoka Ito , Takuji Nakashima , Akira Nozawa
IPC分类号: A61K31/4178 , A61P17/00 , A61P31/10
CPC分类号: A61K47/10 , A61K9/7015 , A61K31/4178 , A61K47/38
摘要: An object of the present invention is to provide a medicinal composition useful for external application in the treatment of a fungal infection reaching the lower part of a thick keratin layer. Provided is an antifungal medicinal composition, comprising: (1) a film-forming agent; (2) a water-soluble plasticizer in a form of a solid or a paste at 20° C. at 1 atm; and (3) an antifungal compound represented by a general formula (1) and/or a physiologically acceptable salt thereof.
摘要翻译: 本发明的目的是提供一种可用于外用于治疗到达厚角蛋白层下部的真菌感染的药物组合物。 提供一种抗真菌药用组合物,其包含:(1)成膜剂; (2)在20℃,1atm下固体或糊状形式的水溶性增塑剂; 和(3)由通式(1)表示的抗真菌化合物和/或其生理学上可接受的盐。
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公开(公告)号:US08039452B2
公开(公告)日:2011-10-18
申请号:US10518776
申请日:2003-06-10
申请人: Hideaki Sasagawa , Madoka Ito , Takuji Nakashima , Akira Nozawa
发明人: Hideaki Sasagawa , Madoka Ito , Takuji Nakashima , Akira Nozawa
IPC分类号: A61K31/4164 , A61K47/06
CPC分类号: A61K47/10 , A61K9/7015 , A61K31/4178 , A61K47/38
摘要: An object of the present invention is to provide a medicinal composition useful for external application in the treatment of a fungal infection reaching the lower part of a thick keratin layer. Provided is an antifungal medicinal composition, comprising: (1) a film-forming agent; (2) a water-soluble plasticizer in a form of a solid or a paste at 20° C. at 1 atm; and (3) an antifungal compound represented by a general formula (1) and/or a physiologically acceptable salt thereof.
摘要翻译: 本发明的目的是提供一种可用于外用于治疗到达厚角蛋白层下部的真菌感染的药物组合物。 提供一种抗真菌药用组合物,其包含:(1)成膜剂; (2)在20℃,1atm下固体或糊状形式的水溶性增塑剂; 和(3)由通式(1)表示的抗真菌化合物和/或其生理学上可接受的盐。
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