-
公开(公告)号：US08513296B2
公开(公告)日：2013-08-20
申请号：US13603220
申请日：2012-09-04
IPC分类号： A61K31/4178 , A61P31/10
CPC分类号： A61K9/0014 , A61K31/4178
摘要： Disclosed is an antifungal agent for external use, which is characterized by containing a compound represented by the general formula (1) below, 50-95% by mass of an alcohol, and 0.1-35% by mass of water and/or an anionic surfactant.
摘要翻译： 公开了一种外用抗真菌剂，其特征在于，含有下述通式（1）表示的化合物，50-95质量％的醇和0.1-35质量％的水和/或阴离子 表面活性剂。
-
公开(公告)号：US20120329845A1
公开(公告)日：2012-12-27
申请号：US13603220
申请日：2012-09-04
IPC分类号： A61K31/4178 , A61P31/10
CPC分类号： A61K9/0014 , A61K31/4178
摘要： Disclosed is an antifungal agent for external use, which is characterized by containing a compound represented by the general formula (1) below, 50-95% by mass of an alcohol, and 0.1-35% by mass of water and/or an anionic surfactant.
摘要翻译： 公开了一种外用抗真菌剂，其特征在于含有下述通式（1）表示的化合物，50-95质量％的醇和0.1-35质量％的水和/或阴离子 表面活性剂。
-
公开(公告)号：US08258166B2
公开(公告)日：2012-09-04
申请号：US13365723
申请日：2012-02-03
申请人： Yasushi Murakami , Naoko Kobayashi , Azuma Nishio , Nobuo Kubota
发明人： Yasushi Murakami , Naoko Kobayashi , Azuma Nishio , Nobuo Kubota
IPC分类号： A01N43/52 , A61K31/415 , C07D233/28 , C07D233/91
CPC分类号： A61K9/08 , A61K9/0019 , A61K31/4168 , A61K41/0038 , C07D233/91
摘要： A Cancer radiotherapeutic method using 1-(1-hydroxymethyl-2,3-dihydroxypropyl)oxymethyl-2-nitroimidazole (compound (i), and creatinine in an amount of 0.001 to part by mass with respect to 1 part by mass of compound (1); and irradiation.
摘要翻译： 相对于1质量份化合物，使用1-（1-羟甲基-2,3-二羟丙基）氧甲基-2-硝基咪唑（化合物（i））和肌酸酐0.001〜质量份的癌症放射治疗法 1）和照射。
-
公开(公告)号：US20100204293A1
公开(公告)日：2010-08-12
申请号：US12676346
申请日：2008-09-05
IPC分类号： A61K31/4178 , A61P31/10
CPC分类号： A61K9/0014 , A61K31/4178
摘要： Disclosed is an antifungal agent for external use, which is characterized by containing a compound represented by the general formula (1) below, 50-95% by mass of an alcohol, and 0.1-35% by mass of water and/or an anionic surfactant.
摘要翻译： 公开了一种外用抗真菌剂，其特征在于，含有下述通式（1）表示的化合物，50-95质量％的醇和0.1-35质量％的水和/或阴离子 表面活性剂。
-
公开(公告)号：US20100173965A1
公开(公告)日：2010-07-08
申请号：US12676345
申请日：2008-09-05
CPC分类号： A61K31/4178 , A61K9/0014 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/22 , A61K47/26 , A61K47/32 , A61K47/34
摘要： Disclosed is a pharmaceutical composition for antifungal use, comprising: 1) one or more compounds selected from compounds represented by the general formula (1) below and physiologically acceptable salts thereof; 2) one or more compounds selected from polypropylene glycol, diesters of dibasic acids, triacetin, 2-ethyl-1,3-hexanediol, lauromacrogol, and polyoxyethylene-polyoxypropylene glycol; and 3) one or more compounds selected from glucono-δ-lactone, propylene glycol, glycerin, and lactic acid. General formula (1) (In the formula, X represents a halogen or hydrogen). wherein X represents a halogen or hydrogen.
摘要翻译： 公开了一种用于抗真菌用途的药物组合物，包括：1）一种或多种选自下述通式（1）的化合物及其生理学可接受的盐; 2）一种或多种选自聚丙二醇，二元酸二酯，三醋精，2-乙基-1,3-己二醇，月桂醇和聚氧乙烯 - 聚氧丙烯二醇的化合物; 和3）一种或多种选自葡萄糖酸-δ-内酯，丙二醇，甘油和乳酸的化合物。 通式（1）（式中，X表示卤素或氢）。 其中X表示卤素或氢。
-
公开(公告)号：US20100168200A1
公开(公告)日：2010-07-01
申请号：US12676331
申请日：2008-09-05
CPC分类号： A61K31/4178 , A61K9/0014 , A61K9/08 , A61K31/385 , A61K31/4164 , A61K47/10 , A61K47/38
摘要： Disclosed is an antifungal agent for external use, which is characterized by containing a compound represented by the general formula (1), 50 to 95 mass % of an alcohol such as ethanol, 0.1 to 35 mass % of water or the like, and 0.01 to 5 mass % of a cellulose thickening agent. X is a halogen or H.
摘要翻译： 公开了一种外用抗真菌剂，其特征在于，含有通式（1）表示的化合物，50〜95质量％的醇如乙醇，0.1〜35质量％的水等，0.01 至5质量％的纤维素增稠剂。 X是卤素或H.
-
公开(公告)号：US09480678B2
公开(公告)日：2016-11-01
申请号：US12676331
申请日：2008-09-05
IPC分类号： A61K31/385 , A61K31/4164 , A61K31/4178 , A61K9/00 , A61K47/10 , A61K47/38
CPC分类号： A61K31/4178 , A61K9/0014 , A61K9/08 , A61K31/385 , A61K31/4164 , A61K47/10 , A61K47/38
摘要： Disclosed is an antifungal agent for external use, which is characterized by containing a compound represented by the general formula (1), 50 to 95 mass % of an alcohol such as ethanol, 0.1 to 35 mass % of water or the like, and 0.01 to 5 mass % of a cellulose thickening agent. X is a halogen or H.
-
公开(公告)号：US08258165B2
公开(公告)日：2012-09-04
申请号：US12598044
申请日：2008-04-16
申请人： Yasushi Murakami , Naoko Kobayashi , Azuma Nishio , Nobuo Kubota
发明人： Yasushi Murakami , Naoko Kobayashi , Azuma Nishio , Nobuo Kubota
IPC分类号： A01N43/52 , A61K31/415 , C07D233/28 , C07D233/91
CPC分类号： A61K9/08 , A61K9/0019 , A61K31/4168 , A61K41/0038 , C07D233/91
摘要： To provide a pharmaceutical composition containing a 2-nitroimidazole derivative, which has high solubility in an aqueous carrier and high stability.The pharmaceutical composition is characterized by containing 1-(1-hydroxymethyl-2,3-dihydroxypropyl)oxymethyl-2-nitroimidazole and creatinine, and containing creatinine of 0.001 to 1 part by mass with respect to 1 part by mass of 1-(1-hydroxymethyl-2,3-dihydroxypropyl)oxymethyl-2-nitroimidazole.
-
公开(公告)号：US20120136295A1
公开(公告)日：2012-05-31
申请号：US13365723
申请日：2012-02-03
申请人： Yasushi MURAKAMI , Naoko Kobayashi , Azuma Nishio , Nobuo Kubota
发明人： Yasushi MURAKAMI , Naoko Kobayashi , Azuma Nishio , Nobuo Kubota
IPC分类号： A61M37/00
CPC分类号： A61K9/08 , A61K9/0019 , A61K31/4168 , A61K41/0038 , C07D233/91
摘要： To provide a pharmaceutical composition containing a 2-nitroimidazole derivative, which has high solubility in an aqueous carrier and high stability.The pharmaceutical composition is characterized by containing 1-(1-hydroxymethyl-2,3-dihydroxypropyl)oxymethyl-2-nitroimidazole and creatinine, and containing creatinine of 0.001 to 1 part by mass with respect to 1 part by mass of 1-(1-hydroxymethyl-2,3-dihydroxypropyl)oxymethyl-2-nitroimidazole.
摘要翻译： 提供含有在水性载体中具有高溶解度和高稳定性的2-硝基咪唑衍生物的药物组合物。 该药物组合物的特征在于含有1-（1-羟甲基-2,3-二羟丙基）氧甲基-2-硝基咪唑和肌酸酐，相对于1质量份的1-（1 - 羟基甲基-2,3-二羟丙基）氧基甲基-2-硝基咪唑。
-
公开(公告)号：US20120130148A1
公开(公告)日：2012-05-24
申请号：US13362545
申请日：2012-01-31
申请人： Yasushi Murakami , Naoko Kobayashi , Azuma Nishio , Nobuo Kubota
发明人： Yasushi Murakami , Naoko Kobayashi , Azuma Nishio , Nobuo Kubota
IPC分类号： A61N5/00
CPC分类号： A61K31/4168 , A61K9/0019 , A61K47/12 , A61K47/18 , A61K47/22
摘要： To provide a pharmaceutical composition which can enhance the storage stability of 1-(1-hydroxymethyl-2,3-dihydroxypropyloxymethyl)-2-nitroimidazole without impairing the effect of the compound.The pharmaceutical composition includes 1-(1-hydroxymethyl-2,3-dihydroxypropyloxymethyl)-2-nitroimidazole, which is represented by formula (1): and a compound having chelating ability.
-
-
-
-
-
-
-
-
-
搜索结果
18 条记录 (耗时 0.014 秒)