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公开(公告)号：US08058303B2
公开(公告)日：2011-11-15
申请号：US12281973
申请日：2006-10-02
IPC分类号： A61K31/4178
CPC分类号： C07D409/06 , A61K9/0014 , A61K31/4178 , A61K47/30
摘要： Provided is a pharmaceutical composition for external use which includes the following components: 1) luliconazole and/or a salt thereof; 2) N-methyl-2-pyrollidone; and 3) benzyl alcohol and/or diester of a dibasic acid. The diester of the dibasic acid is a diethyl ester or a diisopropyl ester of a dibasic acid having 6-10 carbon atoms. The pharmaceutical composition is useful for the treatment of a mycotic disease such as foot trichophytosis, trichophytosis corporis, trichophytosis on a hard keratin or hyperkeratotic portion, onychomycosis, particularly on a nail, or dermatomycosis.
摘要翻译： 本发明提供一种外用药物组合物，其含有以下成分：1）柳氮唑醇和/或其盐; 2）N-甲基-2-吡咯烷酮; 和3）二元酸的苄醇和/或二酯。 二元酸的二酯是具有6-10个碳原子的二元酸的二酯或二异丙酯。 药物组合物可用于治疗真菌病，例如脚毛虫病，头毛虫病，硬角蛋白或角化过度部分的毛发症，甲癣，特别是指甲或皮肤真皮病。
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公开(公告)号：US07660308B2
公开(公告)日：2010-02-09
申请号：US11583117
申请日：2006-10-19
申请人： Kenichi Hasegawa , Akira Nozawa , Minoru Tateno , Kenichi Miyama
发明人： Kenichi Hasegawa , Akira Nozawa , Minoru Tateno , Kenichi Miyama
IPC分类号： H04L12/46
CPC分类号： H04L49/102 , H04L49/3009 , H04L49/357 , H04L49/552 , H04L49/557
摘要： A transmission apparatus that does not include a plurality of switches, that cross-connects a signal, and that can handle various redundancy settings determined by a user. An address information generation section generates address information indicative of the destination of a signal, from redundancy setting information and cross connect setting information. An activation information setting section activates and deactivates activation information included in the address information when failure occurs. An address information insertion section inserts the address information stored in an address information storage section into the signal and outputs the signal to a bus. A signal output section receives the signal having the address information that is the same as own address information and outputs the signal to a next stage in the case of the activation information indicating activation.
摘要翻译： 不包括多个开关的传输装置，其交叉连接信号，并且可以处理由用户确定的各种冗余设置。 地址信息生成部从冗余设定信息和交叉连接设定信息生成表示信号的目的地的地址信息。 当发生故障时，激活信息设置部分激活和停用包括在地址信息中的激活信息。 地址信息插入部将存储在地址信息存储部中的地址信息插入到信号中，并将该信号输出到总线。 信号输出部分接收具有与自身地址信息相同的地址信息的信号，并且在激活信息指示激活的情况下将信号输出到下一级。
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公开(公告)号：US20090030059A1
公开(公告)日：2009-01-29
申请号：US12281969
申请日：2006-10-02
IPC分类号： A61K31/4178
CPC分类号： A61K31/4178 , A61K31/19 , A61K2300/00
摘要： Provided is a pharmaceutical composition for external use, including: (i) luliconazole represented by the following structural formula (1) and/or a salt thereof; and (ii) α-hydroxycarboxylic acid and/or a salt thereof.
摘要翻译： 本发明提供一种外用药物组合物，其包括：（i）由以下结构式（1）表示的联利康唑和/或其盐; 和（ii）α-羟基羧酸和/或其盐。
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公开(公告)号：US20080002706A1
公开(公告)日：2008-01-03
申请号：US11583117
申请日：2006-10-19
申请人： Kenichi Hasegawa , Akira Nozawa , Minoru Tateno , Kenichi Miyama
发明人： Kenichi Hasegawa , Akira Nozawa , Minoru Tateno , Kenichi Miyama
IPC分类号： H04L12/56
CPC分类号： H04L49/102 , H04L49/3009 , H04L49/357 , H04L49/552 , H04L49/557
摘要： A transmission apparatus that does not include a plurality of switches, that cross-connects a signal, and that can handle various redundancy settings determined by a user. An address information generation section generates address information indicative of the destination of a signal, from redundancy setting information and cross connect setting information. An activation information setting section activates and deactivates activation information included in the address information when failure occurs. An address information insertion section inserts the address information stored in an address information storage section into the signal and outputs the signal to a bus. A signal output section receives the signal having the address information that is the same as own address information and outputs the signal to a next stage in the case of the activation information indicating activation.
摘要翻译： 不包括多个开关的传输装置，其交叉连接信号，并且可以处理由用户确定的各种冗余设置。 地址信息生成部从冗余设定信息和交叉连接设定信息生成表示信号的目的地的地址信息。 当发生故障时，激活信息设置部分激活和停用包括在地址信息中的激活信息。 地址信息插入部将存储在地址信息存储部中的地址信息插入到信号中，并将该信号输出到总线。 信号输出部分接收具有与自身地址信息相同的地址信息的信号，并且在激活信息指示激活的情况下将信号输出到下一级。
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公开(公告)号：US20050250174A1
公开(公告)日：2005-11-10
申请号：US11153181
申请日：2005-06-15
申请人： Takuji Nakashima , Akira Nozawa , Takao Ito
发明人： Takuji Nakashima , Akira Nozawa , Takao Ito
CPC分类号： C12Q1/18 , C12Q1/06 , G01N33/5088
摘要： A correct viable cell number of a microorganism in a biological tissue is measured by cultivating a fragment of the biological tissue such as skin infected with the microorganism and administered with an antimicrobial agent, in a medium containing a phospholipid, a nonionic surfactant, or both of the phospholipid and the nonionic surfactant.
摘要翻译： 通过在含有磷脂，非离子表面活性剂或两者的培养基中培养生物组织的片段，例如感染微生物的皮肤并施用抗微生物剂来测量生物组织中微生物的正确的活细胞数 磷脂和非离子表面活性剂。
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公开(公告)号：US5593540A
公开(公告)日：1997-01-14
申请号：US429648
申请日：1995-04-27
申请人： Kazushi Tomita , Yoshikazu Ito , Motohiro Hirano , Akira Nozawa , Hiromitsu Matsuo , Shunichi Iimuro , Shigeki Tozawa , Yutaka Miura
发明人： Kazushi Tomita , Yoshikazu Ito , Motohiro Hirano , Akira Nozawa , Hiromitsu Matsuo , Shunichi Iimuro , Shigeki Tozawa , Yutaka Miura
CPC分类号： H01J37/32449 , H01J37/3244 , H01J37/32532 , H01J37/32724 , H01J2237/3347
摘要： The present invention provides a plasma etching system, comprising a process chamber enclosing a plasma, means for evacuating said process chamber, a chuck electrode for supporting a substrate, a shower electrode positioned to face said chuck electrode and provided with a large number of small holes, a power source for applying a plasma voltage between the chuck electrode and said shower electrode, gas supply means communicating with said small holes of the shower electrode for supplying a plasma-forming gas into the process chamber through the small holes, and means for controlling said gas supply means such that said plasma-forming gas flows through said small holes at a mass flow rate of at least 620 kg/m.sup.2 /hr.
摘要翻译： 本发明提供了一种等离子体蚀刻系统，其包括封装等离子体的处理室，用于抽出处理室的装置，用于支撑基板的卡盘电极，与所述卡盘电极相对设置并设有大量小孔的喷淋电极 用于在所述卡盘电极和所述淋浴电极之间施加等离子体电压的电源，与所述淋浴电极的所述小孔连通的气体供给装置，用于通过所述小孔将等离子体形成气体供给到所述处理室，以及用于控制 所述气体供给装置使得所述等离子体形成气体以至少620kg / m 2 / hr的质量流量流过所述小孔。
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公开(公告)号：US08741941B2
公开(公告)日：2014-06-03
申请号：US13240833
申请日：2011-09-22
申请人： Hideaki Sasagawa , Madoka Ito , Takuji Nakashima , Akira Nozawa
发明人： Hideaki Sasagawa , Madoka Ito , Takuji Nakashima , Akira Nozawa
IPC分类号： A01N43/50 , A61K31/415 , A01N43/26 , A61K31/385 , A61F13/00 , A61K9/70
CPC分类号： A61K47/10 , A61K9/7015 , A61K31/4178 , A61K47/38
摘要： An object of the present invention is to provide a medicinal composition useful for external application in the treatment of a fungal infection reaching the lower part of a thick keratin layer. Provided is an antifungal medicinal composition, comprising: (1) a film-forming agent; (2) a water-soluble plasticizer in a form of a solid or a paste at 20° C. at 1 atm; and (3) an antifungal compound represented by a general formula (1) and/or a physiologically acceptable salt thereof.
摘要翻译： 本发明的目的是提供一种可用于外用于治疗到达厚角蛋白层下部的真菌感染的药物组合物。 提供一种抗真菌药用组合物，其包含：（1）成膜剂; （2）在20℃，1atm下固体或糊状形式的水溶性增塑剂; 和（3）由通式（1）表示的抗真菌化合物和/或其生理学上可接受的盐。
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公开(公告)号：US20120015996A1
公开(公告)日：2012-01-19
申请号：US13240833
申请日：2011-09-22
申请人： Hideaki Sasagawa , Madoka Ito , Takuji Nakashima , Akira Nozawa
发明人： Hideaki Sasagawa , Madoka Ito , Takuji Nakashima , Akira Nozawa
IPC分类号： A61K31/4178 , A61P17/00 , A61P31/10
CPC分类号： A61K47/10 , A61K9/7015 , A61K31/4178 , A61K47/38
摘要： An object of the present invention is to provide a medicinal composition useful for external application in the treatment of a fungal infection reaching the lower part of a thick keratin layer. Provided is an antifungal medicinal composition, comprising: (1) a film-forming agent; (2) a water-soluble plasticizer in a form of a solid or a paste at 20° C. at 1 atm; and (3) an antifungal compound represented by a general formula (1) and/or a physiologically acceptable salt thereof.
摘要翻译： 本发明的目的是提供一种可用于外用于治疗到达厚角蛋白层下部的真菌感染的药物组合物。 提供一种抗真菌药用组合物，其包含：（1）成膜剂; （2）在20℃，1atm下固体或糊状形式的水溶性增塑剂; 和（3）由通式（1）表示的抗真菌化合物和/或其生理学上可接受的盐。
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公开(公告)号：US08039452B2
公开(公告)日：2011-10-18
申请号：US10518776
申请日：2003-06-10
申请人： Hideaki Sasagawa , Madoka Ito , Takuji Nakashima , Akira Nozawa
发明人： Hideaki Sasagawa , Madoka Ito , Takuji Nakashima , Akira Nozawa
IPC分类号： A61K31/4164 , A61K47/06
CPC分类号： A61K47/10 , A61K9/7015 , A61K31/4178 , A61K47/38
摘要： An object of the present invention is to provide a medicinal composition useful for external application in the treatment of a fungal infection reaching the lower part of a thick keratin layer. Provided is an antifungal medicinal composition, comprising: (1) a film-forming agent; (2) a water-soluble plasticizer in a form of a solid or a paste at 20° C. at 1 atm; and (3) an antifungal compound represented by a general formula (1) and/or a physiologically acceptable salt thereof.
摘要翻译： 本发明的目的是提供一种可用于外用于治疗到达厚角蛋白层下部的真菌感染的药物组合物。 提供一种抗真菌药用组合物，其包含：（1）成膜剂; （2）在20℃，1atm下固体或糊状形式的水溶性增塑剂; 和（3）由通式（1）表示的抗真菌化合物和/或其生理学上可接受的盐。
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公开(公告)号：US06586633B1
公开(公告)日：2003-07-01
申请号：US09762678
申请日：2001-04-05
申请人： Masayuki Yuasa , Yukio Kawazu , Toshimitsu Suzuki , Toshiro Majima , Takao Itoh , Takuji Nakashima , Akira Nozawa , Hiroyuki Takimoto , Kouji Yokoyama
发明人： Masayuki Yuasa , Yukio Kawazu , Toshimitsu Suzuki , Toshiro Majima , Takao Itoh , Takuji Nakashima , Akira Nozawa , Hiroyuki Takimoto , Kouji Yokoyama
IPC分类号： C07C21121
CPC分类号： C07C215/28 , C07C17/14 , C07C17/16 , C07C45/004 , C07C45/565 , C07C45/63 , C07C211/21 , C07C211/27 , C07C211/28 , C07C211/29 , C07C211/35 , C07C215/30 , C07C223/02 , C07C225/16 , C07C225/26 , C07C2601/02 , C07C25/02 , C07C49/76 , C07C47/546 , C07C49/80
摘要： The present invention relates to amine derivatives represented by formula (1) or salts thereof. R3 represents C1-C3 alkyl, hydroxylated C1-C5 alkyl, C1-C5 acyl; C2-C5 alkenyl, or a halogen atom; and k, l, and m are each an integer of 1 to 4.) Exhibiting excellent antifungal effect, these compounds are highly useful as antifungal agents, antifungal compositions, drugs, etc.
摘要翻译： 本发明涉及由式（1）表示的胺衍生物或其盐.R 3表示C 1 -C 3烷基，羟基化的C 1 -C 5烷基，C 1 -C 5酰基; C 2 -C 5烯基或卤素原子; 并且k，l和m各自为1〜4的整数。）具有优异的抗真菌效果，这些化合物作为抗真菌剂，抗真菌剂，药物等是非常有用的。
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