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    Amide compound
    1.
    发明授权
    Amide compound 失效
    酰胺化合物

    公开(公告)号：US07851473B2

    公开(公告)日：2010-12-14

    申请号：US11667821

    申请日：2005-11-17

    申请人： Takahiro Matsumoto ,  Masakuni Kori ,  Junichi Miyazaki ,  Yoshihiro Kiyota

    发明人： Takahiro Matsumoto ,  Masakuni Kori ,  Junichi Miyazaki ,  Yoshihiro Kiyota

    IPC分类号： A61K31/501 ,  A61K31/497 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12

    CPC分类号： C12Q1/34 ,  A61K31/495 ,  C07D261/20 ,  C07D285/08 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  G01N33/6896 ,  G01N2333/978 ,  G01N2500/00 ,  G01N2800/28

    摘要： There is provided a FAAH inhibitor and a prophylactic or therapeutic agent for cerebrovascular disorders or sleep disorders comprising it. The prophylactic or therapeutic agent comprises a compound of the formula (I0): wherein Z is oxygen or sulfur; R1 is aryl which may be substituted, or a heterocyclic group which may be substituted; R1a is a hydrogen atom, a hydrocarbon group which may be substituted, hydroxyl, etc.; R2 is piperidin-1,4-diyl which may be substituted, or piperazin-1,4-diyl which may be substituted; R3 is a group formed by eliminating two hydrogen atoms from a 5-membered aromatic heterocyclic group having 1 to 3 heteroatoms selected from nitrogen, oxygen and sulfur, which may be further substituted, —CO—, etc.; and R4 is a hydrocarbon group which may be substituted, or a heterocyclic group which may be substituted; or a salt thereof.

    摘要翻译： 提供了FAAH抑制剂和包含其的脑血管障碍或睡眠障碍的预防或治疗剂。 预防或治疗剂包括式（I0）化合物：其中Z是氧或硫; R1可以被取代的芳基，或可被取代的杂环基; R1a为氢原子，可被取代的烃基，羟基等; R2是可被取代的哌啶-1,4-二基，或可被取代的哌嗪-1,4-二基; R3是通过从具有1至3个选自氮，氧和硫的杂原子的5元芳族杂环基中除去两个氢原子而形成的基团，其可进一步被-CO-等取代; R 4为可被取代的烃基，或可被取代的杂环基; 或其盐。

    Amide Compound
    2.
    发明申请
    Amide Compound 失效
    酰胺化合物

    公开(公告)号：US20080312226A1

    公开(公告)日：2008-12-18

    申请号：US11667821

    申请日：2005-11-17

    申请人： Takahiro Matsumoto ,  Masakuni Kori ,  Junichi Miyazaki ,  Yoshihiro Kiyota

    发明人： Takahiro Matsumoto ,  Masakuni Kori ,  Junichi Miyazaki ,  Yoshihiro Kiyota

    IPC分类号： A61K31/5377 ,  C07D417/14 ,  C12Q1/34 ,  A61P35/00 ,  A61P25/28 ,  A61K31/496

    CPC分类号： C12Q1/34 ,  A61K31/495 ,  C07D261/20 ,  C07D285/08 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  G01N33/6896 ,  G01N2333/978 ,  G01N2500/00 ,  G01N2800/28

    摘要： There is provided a FAAH inhibitor and a prophylactic or therapeutic agent for cerebrovascular disorders or sleep disorders comprising it. The prophylactic or therapeutic agent comprises a compound of the formula (I0): R1—C—R2—R3—R4 (I0)wherein Z is oxygen or sulfur; R1 is aryl which may be substituted, or a heterocyclic group which may be substituted; R1a is a hydrogen atom, a hydrocarbon group which may be substituted, hydroxyl, etc.; R2 is piperidin-1,4-diyl which may be substituted, or piperazin-1,4-diyl which may be substituted; R3 is a group formed by eliminating two hydrogen atoms from a 5-membered aromatic heterocyclic group having 1 to 3 heteroatoms selected from nitrogen, oxygen and sulfur, which may be further substituted, —CO—, etc.; and R4 is a hydrocarbon group which may be substituted, or a heterocyclic group which may be substituted; or a salt thereof.

    摘要翻译： 提供了FAAH抑制剂和包含其的脑血管障碍或睡眠障碍的预防或治疗剂。 预防或治疗剂包含式（I0）的化合物：其中Z是氧或硫的R1-C-R2-R3-R4（I0）; R1可以被取代的芳基，或可被取代的杂环基; R1a为氢原子，可被取代的烃基，羟基等; R2是可被取代的哌啶-1,4-二基，或可被取代的哌嗪-1,4-二基; R3是通过从具有1至3个选自氮，氧和硫的杂原子的5元芳族杂环基中除去两个氢原子而形成的基团，其可进一步被-CO-等取代; R 4为可被取代的烃基，或可被取代的杂环基; 或其盐。

    Agent for preventing or treating organ functional disorders and organ dysfunction
    6.
    发明申请
    Agent for preventing or treating organ functional disorders and organ dysfunction 审中-公开
    用于预防或治疗器官功能障碍和器官功能障碍的药剂

    公开(公告)号：US20060241096A1

    公开(公告)日：2006-10-26

    申请号：US11473560

    申请日：2006-06-23

    申请人： Yasuo Sugiyama ,  Tomoyuki Nishimoto ,  Yoshihiro Kiyota

    发明人： Yasuo Sugiyama ,  Tomoyuki Nishimoto ,  Yoshihiro Kiyota

    IPC分类号： A61K31/553

    CPC分类号： C07D413/04 ,  A61K31/553 ,  C07D267/14 ,  C07D281/10 ,  C07D413/06 ,  C07D413/12 ,  C07D417/04

    摘要： The present invention provides an agent for preventing or treating organ functional disorders, an agent for preventing or treating organ dysfunction and an agent for preventing or treating obesity and deuteropathy thereof, each of which comprises a compound having an effect of increasing ubiquinone or a salt thereof or a prodrug thereof; as well as a ubiquinone increasing agent comprising a compound having a squalene synthase inhibitory effect or a salt thereof or a prodrug thereof.

    摘要翻译： 本发明提供了用于预防或治疗器官功能障碍的药剂，用于预防或治疗器官功能障碍的药剂和用于预防或治疗肥胖症及其脱发病的药剂，其各自包括具有增加泛醌或其盐的作用的化合物 或其前药; 以及含有具有角鲨烯合酶抑制作用的化合物或其前体药物的泛醌增加剂。