公开(公告)号：US20050181462A1

公开(公告)日：2005-08-18

申请号：US10516705

申请日：2003-06-02

申请人： Takahito Hara ,  Masami Kusaka ,  Junichi Miyazaki

发明人： Takahito Hara ,  Masami Kusaka ,  Junichi Miyazaki

IPC分类号： A61K45/00 ,  A61P5/28 ,  A61P35/00 ,  A61P43/00 ,  C07K14/72 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/09 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/02 ,  C12Q1/68 ,  C12R1/91 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53 ,  G01N33/566 ,  G01N33/574 ,  G01N33/74 ,  C12N5/08

CPC分类号： C07K14/721 ,  C12N5/0693 ,  G01N33/5011 ,  G01N33/574 ,  G01N33/57434 ,  G01N33/74

摘要： The present invention provides a mutant androgen receptor (AR) useful for screening an agent for the prophylaxis/treatment of androgen-independent cancer and the like, DNA encoding the AR and the like. It also provides a method of producing a mutant AR expressing cancer cell line in vitro, a method of screening for an anti-antiandrogen drug using the mutant AR expressing cancer cell line obtained by this method, a method of classifying anti-androgen drugs, a cocktail therapy agent comprising a combination of anti-androgen drugs classified by this method and the like.

摘要翻译： 本发明提供了可用于筛选用于预防/治疗雄激素非依赖性癌症等的试剂的突变型雄激素受体（AR），编码AR等的DNA。 本发明还提供了一种在体外产生突变型AR表达癌细胞系的方法，使用通过该方法获得的表达突变型AR的癌细胞系筛选抗雄激素药物的方法，抗雄激素药物分类方法 包含通过该方法分类的抗雄激素药物的组合的鸡尾酒治疗剂等。

公开(公告)号：US4011298A

公开(公告)日：1977-03-08

申请号：US533294

申请日：1974-12-16

申请人： Suguru Fukui ,  Haruo Nishino ,  Yohji Kameoka ,  Junichi Miyazaki ,  Toshio Kuroda ,  Shinichi Konishi

发明人： Suguru Fukui ,  Haruo Nishino ,  Yohji Kameoka ,  Junichi Miyazaki ,  Toshio Kuroda ,  Shinichi Konishi

IPC分类号： B01D53/60 ,  B01D53/34 ,  B01D53/77 ,  C01B21/00

CPC分类号： B01D53/34

摘要： Waste gas containing sulfur oxide (SO.sub.x) and nitrogen oxide (NO.sub.x) is mixed with an ozone-containing gas to have the value x of NO.sub.x fall in the range of 1.2 to 2.5 and thereafter brought into contact with an aqueous solution containing sulfuric acid, nitric acid and an iron compound to be deprived of SO.sub.x and NO.sub.x. To the solution with which the waste gas has been brought into contact, air or oxygen is added to effect oxidation of the part of said oxides still remaining therein in an unoxidized state and regenerate the activity of the iron compound functioning as a catalyst. Part of the solution to which the addition of air or oxygen has been made is recycled as the solution for the purpose of contact with waste gas.

公开(公告)号：US20080021069A1

公开(公告)日：2008-01-24

申请号：US11664728

申请日：2005-10-07

申请人： Fumio Itoh ,  Satoshi Sasaka ,  Junichi Miyazaki ,  Nobuhiro Suzuki

发明人： Fumio Itoh ,  Satoshi Sasaka ,  Junichi Miyazaki ,  Nobuhiro Suzuki

IPC分类号： A61K31/4439 ,  A61K31/4168 ,  A61P25/00 ,  A61P29/00 ,  A61P37/00 ,  A61P5/00 ,  C07D235/04 ,  C07D401/04 ,  C07D235/28 ,  A61P9/00 ,  A61P39/00 ,  A61P35/00 ,  A61P27/00 ,  A61K31/4184

CPC分类号： C07D401/04 ,  C07D235/28 ,  C07D235/30 ,  C07D401/12 ,  C07D405/10 ,  C07D413/10

摘要： The present invention relates to a GPR40 receptor function regulator comprising a fused imidazole compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof or a prodrug thereof. The GPR40 receptor function regulator is useful as an agent for the prophylaxis or treatment of obesity, hyperinsulinemia, type 2 diabetes and the like.

摘要翻译： 本发明涉及包含由下式表示的稠合咪唑化合物的GPR40受体功能调节剂：其中每个符号如说明书中所定义，或其盐或其前药。 GPR40受体功能调节剂可用作预防或治疗肥胖，高胰岛素血症，2型糖尿病等的药剂。

公开(公告)号：US5811260A

公开(公告)日：1998-09-22

申请号：US373143

申请日：1989-06-23

申请人： Junichi Miyazaki ,  Ken-ichi Yamamura ,  Masatake Araki ,  Hiroshi Yonemura ,  Chikateru Nozaki

发明人： Junichi Miyazaki ,  Ken-ichi Yamamura ,  Masatake Araki ,  Hiroshi Yonemura ,  Chikateru Nozaki

IPC分类号： C07K14/02 ,  C12N9/38 ,  C12N15/85 ,  C12P21/02

CPC分类号： C07K14/005 ,  C12N15/85 ,  C12N9/2471 ,  C12Y302/01023 ,  C12N2730/10122 ,  C12N2800/108 ,  C12N2830/00 ,  C12N2830/005 ,  C12N2830/15 ,  C12N2830/60 ,  C12N2830/90 ,  C12N2840/44

摘要： An expression vector for the expression of an exogenous gene in an animal cell, which contains a chick .beta.-actin gene promoter and a restriction enzyme site for incorporating an exogenous gene at the downstream of said promoter and a process for expressing an exogenous gene, which comprises incorporating said exogenous gene into the expression vector at the restriction enzyme site for incorporating the exogenous gene, introducing said vector into an animal cell and culturing the obtained transformed animal cell. The expression system of the present invention can be applied to an expression of any exogenous gene and has an extremely high expression efficiency and is applicable to a wide range of host cells, and hence can sufficiently be utilized for industrial-scale production of a useful material.

摘要翻译： 用于在动物细胞中表达外源基因的表达载体，其含有小鸡β-肌动蛋白基因启动子和用于在所述启动子的下游并入外源基因的限制酶位点和表达外源基因的方法，其中 包括将所述外源基因并入限制酶位点的表达载体中，用于掺入外源基因，将所述载体导入动物细胞并培养获得的转化的动物细胞。 本发明的表达系统可以应用于任何外源基因的表达，具有极高的表达效率，适用于广泛的宿主细胞，因此可充分利用于有用材料的工业规模生产 。

公开(公告)号：US07721215B2

公开(公告)日：2010-05-18

申请号：US10067310

申请日：2002-02-07

申请人： Katsushi Fujii ,  Shinichi Kanai ,  Takao Yoshimine ,  Shigehiko Nishizawa ,  Junichi Miyazaki ,  Yousuke Noumi

发明人： Katsushi Fujii ,  Shinichi Kanai ,  Takao Yoshimine ,  Shigehiko Nishizawa ,  Junichi Miyazaki ,  Yousuke Noumi

IPC分类号： G06F3/00

CPC分类号： G06Q10/107 ,  G06Q10/02 ,  G06Q30/02

摘要： In a service providing system, a live-distribution service for live-distributing contents supplied according to a reservation, and a chat service for providing the use of a chat space corresponding to the reservation for live distribution are provided. After the live distribution finishes, a communication server sends the whole or a part of the contents of chatting performed in the chat space corresponding to the reservation for the live distribution, to a personal computer. With this, even if the user of the personal computer, who supplies the contents, could not participate in a chat with a user of another personal computer while capturing the contents, for example, the user of the personal computer can check the contents of the chat later.

摘要翻译： 在服务提供系统中，提供根据预约提供的实时分发内容的实时分配服务，以及用于提供对应于用于实时分配的预约的聊天空间的聊天服务。 在实时分配完成之后，通信服务器将与在线分配的预约相对应的聊天空间中执行的聊天内容的全部或一部分发送到个人计算机。 这样，即使提供内容的个人计算机的用户在捕获内容时也不能参与与另一个人计算机的用户的聊天，例如，个人计算机的用户可以检查个人计算机的内容 以后再谈。

公开(公告)号：US20080312226A1

公开(公告)日：2008-12-18

申请号：US11667821

申请日：2005-11-17

申请人： Takahiro Matsumoto ,  Masakuni Kori ,  Junichi Miyazaki ,  Yoshihiro Kiyota

发明人： Takahiro Matsumoto ,  Masakuni Kori ,  Junichi Miyazaki ,  Yoshihiro Kiyota

IPC分类号： A61K31/5377 ,  C07D417/14 ,  C12Q1/34 ,  A61P35/00 ,  A61P25/28 ,  A61K31/496

CPC分类号： C12Q1/34 ,  A61K31/495 ,  C07D261/20 ,  C07D285/08 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  G01N33/6896 ,  G01N2333/978 ,  G01N2500/00 ,  G01N2800/28

摘要： There is provided a FAAH inhibitor and a prophylactic or therapeutic agent for cerebrovascular disorders or sleep disorders comprising it. The prophylactic or therapeutic agent comprises a compound of the formula (I0): R1—C—R2—R3—R4 (I0)wherein Z is oxygen or sulfur; R1 is aryl which may be substituted, or a heterocyclic group which may be substituted; R1a is a hydrogen atom, a hydrocarbon group which may be substituted, hydroxyl, etc.; R2 is piperidin-1,4-diyl which may be substituted, or piperazin-1,4-diyl which may be substituted; R3 is a group formed by eliminating two hydrogen atoms from a 5-membered aromatic heterocyclic group having 1 to 3 heteroatoms selected from nitrogen, oxygen and sulfur, which may be further substituted, —CO—, etc.; and R4 is a hydrocarbon group which may be substituted, or a heterocyclic group which may be substituted; or a salt thereof.

摘要翻译： 提供了FAAH抑制剂和包含其的脑血管障碍或睡眠障碍的预防或治疗剂。 预防或治疗剂包含式（I0）的化合物：其中Z是氧或硫的R1-C-R2-R3-R4（I0）; R1可以被取代的芳基，或可被取代的杂环基; R1a为氢原子，可被取代的烃基，羟基等; R2是可被取代的哌啶-1,4-二基，或可被取代的哌嗪-1,4-二基; R3是通过从具有1至3个选自氮，氧和硫的杂原子的5元芳族杂环基中除去两个氢原子而形成的基团，其可进一步被-CO-等取代; R 4为可被取代的烃基，或可被取代的杂环基; 或其盐。

公开(公告)号：US5171677A

公开(公告)日：1992-12-15

申请号：US404500

申请日：1989-09-08

申请人： Masashi Sakaguchi ,  Hiroaki Maeda ,  Michitaka Yamamoto ,  Junichi Miyazaki

发明人： Masashi Sakaguchi ,  Hiroaki Maeda ,  Michitaka Yamamoto ,  Junichi Miyazaki

IPC分类号： C12N15/09 ,  A61K39/255 ,  C07K14/055 ,  C12N7/00 ,  C12N15/869 ,  C12R1/92

CPC分类号： C12N15/86 ,  A61K39/12 ,  A61K39/255 ,  C07K14/005 ,  C12N2710/16322 ,  C12N2710/16334 ,  C12N2710/16343

摘要： A recombinant Marek's disease virus which comprises a Marek's disease virus genom and a DNA fragment incorporated therein, said DNA fragment being constructed by incorporating a promoter derived from an animal cell or an animal virus and a structural gene coding for an exogenous protein into a gene fragment derived from a Marek's disease virus, a process for preparing the same which comprises preparing a gene fragment wherein a structural gene coding for an exogenous gene is linked to the downstream of a promoter derived from an animal cell or an animal virus, incorporating said gene fragment into a BamHI - H fragment of a gene of a Marek's disease virus type I, and incorporating said fragment into a Marek's disease virus type I genome, and a multivalent live vaccine for birds comprising the same.

公开(公告)号：US07739610B2

公开(公告)日：2010-06-15

申请号：US10067350

申请日：2002-02-07

申请人： Katsushi Fujii ,  Shinichi Kanai ,  Takao Yoshimine ,  Shigehiko Nishizawa ,  Junichi Miyazaki ,  Yousuke Noumi

发明人： Katsushi Fujii ,  Shinichi Kanai ,  Takao Yoshimine ,  Shigehiko Nishizawa ,  Junichi Miyazaki ,  Yousuke Noumi

IPC分类号： G06F3/00

CPC分类号： H04N21/4143 ,  H04N7/15 ,  H04N21/2187 ,  H04N21/47214 ,  H04N21/4753 ,  H04N21/4788

摘要： In a service providing system, a live-distribution service for live-distributing contents supplied according to a reservation, and a chat service for providing the use of a chat space corresponding to the reservation for the live distribution are provided. When a personal computer and another personal computer use the live-distribution service and the chat service, they need to be authenticated by a streaming server and a communication server. For authentication, both the streaming server and the communication server use a shared password registered in a reservation data base when the live distribution is reserved.

摘要翻译： 在服务提供系统中，提供根据预约提供的实时分发内容的实时分配服务，以及用于提供对应于用于实时分配的预约的聊天空间的聊天服务的聊天服务。 当个人计算机和另一个个人计算机使用实时分发服务和聊天服务时，需要由流服务器和通信服务器进行认证。 对于认证，流媒体服务器和通信服务器在保留实况分发时使用注册在预约数据库中的共享密码。

公开(公告)号：US06194634B1

公开(公告)日：2001-02-27

申请号：US09213864

申请日：1998-12-17

申请人： Susumu Seino ,  Takashi Miki ,  Junichi Miyazaki

发明人： Susumu Seino ,  Takashi Miki ,  Junichi Miyazaki

IPC分类号： A01K67027

CPC分类号： C12N15/8509 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0306 ,  A01K2267/0362 ,  C07K14/705 ,  C12N2517/02

摘要： A Kir6.2 gene-defective, non-human mammal, a mouse in particular, its tissues and cells are provided, wherein the ATP-sensitive potassium channel Kir6.2 gene, one of the subunits of KATP channels essential for insulin secretion by pancreatic &bgr;-cells, is lost from one or both of the allelic loci.

摘要翻译： 提供了一种Kir6.2基因缺陷型非人类哺乳动物，特别是小鼠，其组织和细胞，其中ATP敏感性钾通道Kir6.2基因，胰岛素分泌所必需的KATP通道亚基之一 β细胞从一个或两个等位基因座丢失。

公开(公告)号：US5281531A

公开(公告)日：1994-01-25

申请号：US844295

申请日：1992-02-28

申请人： Kenichiro Miyagawa ,  Naoyuki Kanzaki ,  Junichi Miyazaki

发明人： Kenichiro Miyagawa ,  Naoyuki Kanzaki ,  Junichi Miyazaki

IPC分类号： C12N1/21 ,  C12N9/12 ,  C12N15/09 ,  C12N15/52 ,  C12N15/54 ,  C12N15/75 ,  C12P19/02 ,  C12R1/125 ,  C12N15/74

CPC分类号： C12N15/52 ,  C12N15/75 ,  C12N9/12 ,  C12P19/02

摘要： Disclosed are (1) a method of producing D-ribose which comprises cultivating a microorganism belonging to the genus Bacillus having D-ribose producing ability in a medium, the microorganism belonging to the genus Bacillus containing a DNA sequence participating in expression of a gluconate operon which is partly or wholly modified so as to highly express the gluconate operon in the microorganism belonging to the genus Bacillus, accumulating D-ribose, and collecting D-ribose thus obtained; (2) a novel microorganism belonging to the genus Bacillus having D-ribose producing ability transformed with DNA which contains a DNA sequence participating in expression of a gluconate operon which is partly or wholly modified so as to highly express the gluconate operon in the microorganism belonging to the genus Bacillus; (3) novel DNA in which a promoter of a gluconate operon of a microorganism belonging to the genus Bacillus is modified so as to highly express said gluconate operon in the microorganism belonging to the genus Bacillus; and (4) a novel vector into which DNA is introduced in which a promoter of a gluconate operon of a microorganism belonging to the genus Bacillus is modified so as to highly express the gluconate operon in the microorganism belonging to the genus Bacillus, whereby D-ribose can be produced in stable form in large amounts.

摘要翻译： 公开的是（1）D-核糖的制造方法，其包括在培养基中培养属于具有D-核糖产生能力的芽孢杆菌属的微生物，所述微生物属于含有参与葡萄糖酸盐操纵子表达的DNA序列的芽孢杆菌属 其部分或完全修饰以高度表达属于芽孢杆菌属的微生物中的葡萄糖酸盐操纵子，积聚D-核糖，并收集由此获得的D-核糖; （2）属于芽孢杆菌属的具有D-核糖产生能力的新型微生物，其用DNA转化，所述DNA含有参与表达葡萄糖酸盐操纵子的DNA序列，所述葡萄糖酸盐操纵子部分或全部被修饰以高度表达所属微生物中的葡萄糖酸盐操纵子 对芽孢杆菌属; （3）对属于芽孢杆菌属的微生物的葡萄糖酸盐操纵子的启动子进行了修饰以在属于芽孢杆菌属的微生物中高度表达葡萄糖酸盐操纵子的新型DNA; 和（4）引入DNA的新载体，其中修饰属于芽孢杆菌属的微生物的葡萄糖酸盐操纵子的启动子被修饰以高度表达属于芽孢杆菌属的微生物中的葡萄糖酸盐操纵子，由此D- 核糖可以大量稳定的形式生产。