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公开(公告)号：US4487768A
公开(公告)日：1984-12-11
申请号：US452301
申请日：1982-12-22
申请人： Takao Takaya , Takashi Masugi , Hisashi Takasugi , Kenzi Miyai
发明人： Takao Takaya , Takashi Masugi , Hisashi Takasugi , Kenzi Miyai
IPC分类号： A61K31/545 , A61K31/546 , A61K31/655 , A61P31/04 , C07D501/46
CPC分类号： C07D501/46
摘要： The invention relates to novel compounds of high antimicrobial activity of the formula: ##STR1## wherein R.sup.1 is amino or protected amino,R.sup.2 is carboxy(lower)alkyl or protected carboxy(lower)alkyl, andR.sup.3 is carboxy or protected carboxy,and a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明涉及具有下式的高抗微生物活性的新化合物：其中R 1是氨基或被保护的氨基，R 2是羧基（低级）烷基或被保护的羧基（低级）烷基，R 3是羧基或受保护的羧基， 其药学上可接受的盐。
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2.发明授权7-Substituted-3-vinyl-3-cephem compounds and processes for production of the same 失效7-取代的3-乙烯基-3-头孢烯化合物及其制备方法
公开(公告)号：US4559334A
公开(公告)日：1985-12-17
申请号：US543880
申请日：1983-10-20
IPC分类号： A61K31/545 , C07D20060101 , C07D501/22 , C07D501/24
CPC分类号： C07D501/22
摘要： The invention relates to novel compounds of high antimicrobial activity of the formula: ##STR1## in which R.sup.1 is amino or a protected amino group, andR.sup.2 is carboxy or a protected carboxy group, and a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明涉及具有下式的高抗微生物活性的新化合物：其中R1是氨基或被保护的氨基，R2是羧基或被保护的羧基，及其药学上可接受的盐。
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3.发明授权
公开(公告)号：US4423213A
公开(公告)日：1983-12-27
申请号：US261618
申请日：1981-05-07
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D209/48 , C07D213/75 , C07D239/42 , C07D257/06 , C07D271/06 , C07D271/07 , C07D277/20 , C07D277/46 , C07D277/48 , C07D277/56 , C07D285/08 , C07D417/12 , C07D501/06 , C07D501/18 , C07D501/20 , C07D501/22 , C07D501/24 , C07D501/36 , C07F9/6561
CPC分类号： C07D209/48 , C07D213/75 , C07D239/42 , C07D257/06 , C07D271/06 , C07D271/07 , C07D277/20 , C07D277/46 , C07D277/48 , C07D277/56 , C07D277/587 , C07D285/08 , C07D417/12
摘要： The invention relates to novel 7-acylamino-3-vinylcephalosporanic acid derivatives of antimicrobial activity, and to methods of preparation thereof from novel intermediate compounds of the formula: ##STR1## in which R.sub.C is amino or a group of the formula: ##STR2## wherein R.sup.8 is aryl,A.sup.12 is lower alkylene having a group of the formula: .dbd.N.about.OR.sup.4, wherein R.sup.4 is hydrogen, cyclo(lower) alkenyl, lower alkynyl, lower alkenyl, lower alkenyl substituted by carboxy or a protected carboxy group, lower alkyl, or lower alkyl substituted by one or more substituent(s) selected from carboxy, a protected carboxy group, amino, a protected amino group, cyano, phosphono, a protected phosphono group and a heterocyclic group which may have suitable substituent(s),R.sup.a is a protected amino group,R.sup.b is a protected carboxy group,R.sup.c and R.sup.d are combined to form oxo or a protected oxo group, and X.sup.1 is halogen, andR.sup.2 is carboxy or a protected carboxy group, provided that, when R.sub.C is amino, then R.sup.2 is carboxy, or a salt thereof.
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公开(公告)号：US4379922A
公开(公告)日：1983-04-12
申请号：US213217
申请日：1980-12-05
申请人： Ikuo Ueda , Takao Takaya , Masakazu Kobayashi , Takashi Masugi , Hisashi Takasugi , Hiromu Kochi , Tadashi Kitaguchi
发明人： Ikuo Ueda , Takao Takaya , Masakazu Kobayashi , Takashi Masugi , Hisashi Takasugi , Hiromu Kochi , Tadashi Kitaguchi
IPC分类号： C07D317/30 , C07D319/06 , C07D501/04 , C07D501/14
CPC分类号： C07D317/30 , C07D319/06
摘要： This invention relates to new compounds comprising alkoxyimino dioxy butyric acid cepham derivatives, useful as intermediates in the production of antimicrobial agents.
摘要翻译： 本发明涉及包含烷氧基亚氨基二氧基丁酸头孢类衍生物的新化合物，其可用作生产抗微生物剂的中间体。
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5.发明授权Syn isomer of 7-[2-cyclo(lower) alkoxyimino-2-(2-amino-or substituted aminothiazol-4-yl)acetamido]-3-lower alkanoyloxymethyl or heterocyclicthiomethyl-3-cephem-4-carboxylic acid compounds 失效7- [2-环（低级）烷氧基亚氨基-2-（2-氨基或取代的氨基噻唑-4-基）乙酰氨基] -3-低级烷酰氧基甲基或杂环硫代甲基-3-头孢烯-4-羧酸化合物的同分异构体
公开(公告)号：US4331664A
公开(公告)日：1982-05-25
申请号：US123164
申请日：1980-02-20
申请人： Takao Takaya , Takashi Masugi , Hisashi Takasugi , Hiromu Kochi
发明人： Takao Takaya , Takashi Masugi , Hisashi Takasugi , Hiromu Kochi
IPC分类号： C07D277/20 , C07D277/48 , C07D333/16 , C07D501/36 , A61K31/545 , C07D501/56
CPC分类号： C07D277/20 , C07D277/48 , C07D277/587 , C07D333/16
摘要： Syn isomers of 3-substituted 7-[2-substituted imino-2-substituted acetamido]-3-cephem-4-carboxylic acid and salt bacteriostatic-compounds and pharmaceutical compositions thereof and processes for preparing same.
摘要翻译： 3-取代的7- [2-取代的亚氨基-2-取代的乙酰氨基] -3-头孢烯-4-羧酸和盐抑菌化合物的Syn异构体及其药物组合物及其制备方法。
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6.发明授权7-acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof 失效7-酰氨基-3-乙烯基头孢烷酸衍生物及其制备方法
公开(公告)号：US4960889A
公开(公告)日：1990-10-02
申请号：US462347
申请日：1990-01-03
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D209/48 , C07D213/75 , C07D239/42 , C07D257/06 , C07D271/06 , C07D271/07 , C07D277/20 , C07D277/46 , C07D277/48 , C07D277/56 , C07D285/08 , C07D417/12 , C07D501/06 , C07D501/18 , C07D501/20 , C07D501/22 , C07D501/24 , C07D501/36 , C07F9/6561
CPC分类号： C07D209/48 , C07D213/75 , C07D239/42 , C07D257/06 , C07D271/06 , C07D271/07 , C07D277/20 , C07D277/46 , C07D277/48 , C07D277/56 , C07D277/587 , C07D285/08 , C07D417/12
摘要： Amino-pyridinyl and pyrimidinyl intermediates have been synthesized.
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公开(公告)号：US4904652A
公开(公告)日：1990-02-27
申请号：US785048
申请日：1985-10-09
IPC分类号： C07D501/32 , A61K31/545 , A61K31/546 , A61P31/04 , C07D209/48 , C07D213/75 , C07D239/42 , C07D257/06 , C07D271/06 , C07D271/07 , C07D277/20 , C07D277/46 , C07D277/48 , C07D277/56 , C07D285/08 , C07D417/12 , C07D501/18 , C07D501/22 , C07D501/24 , C07D501/34 , C07D501/36
CPC分类号： C07D209/48 , C07D213/75 , C07D239/42 , C07D257/06 , C07D271/06 , C07D271/07 , C07D277/20 , C07D277/46 , C07D277/48 , C07D277/56 , C07D277/587 , C07D285/08 , C07D417/12
摘要： The compound 7[2-(aminothiazol-4-yl)-2-methyoxyiminoacetamido]-methylthiomethyl-3-cephem-4-carboxylic acid or carboxylic ester thereof, or a pharmaceutically acceptable salt thereof is disclosed as an antimicrobial agent.
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公开(公告)号：US4731443A
公开(公告)日：1988-03-15
申请号：US889189
申请日：1986-07-24
IPC分类号： C07D209/48 , C07D213/75 , C07D239/42 , C07D257/06 , C07D271/06 , C07D271/07 , C07D277/20 , C07D277/46 , C07D277/48 , C07D277/56 , C07D285/08 , C07D417/12 , C07D501/06 , C07D501/22 , C07D501/04 , A61K31/545
CPC分类号： C07D209/48 , C07D213/75 , C07D239/42 , C07D257/06 , C07D271/06 , C07D271/07 , C07D277/20 , C07D277/46 , C07D277/48 , C07D277/56 , C07D277/587 , C07D285/08 , C07D417/12
摘要： The invention relates to novel intermediates for the preparation of antimicrobial compounds, the intermediate being a compound of the formula: ##STR1## in which R.sup.2 is carboxy or a protected carboxy group,R.sup.8 is 2-hydroxyphenyl andZ is a group of the formula:--CH.dbd.CH.sub.2, --CH.sub.2 --X.sup.2, --CH.sub.2 P.sup.+ (R.sup.7).sub.3.X.sup.3-,--CH.dbd.P(R.sup.7).sub.3 OR--CH.sub.2 OH,wherein X.sup.2 and X.sup.3 are each halogen and R.sup.7 is selected from the group consisting of phenyl, tolyl, xylyl and naphthyl, or a salt thereof.
摘要翻译： 本发明涉及用于制备抗微生物化合物的新型中间体，其中间体为下式的化合物：其中R 2为羧基或被保护的羧基，R 8为2-羟基苯基，Z为下式基团： -CH = CH 2，-CH 2 -X 2，-CH 2 P +（R 7）3 X 3 - ， - CH = P（R 7）3 OR-CH 2 OH，其中X 2和X 3各自为卤素，R 7选自苯基， 甲苯基，二甲苯基和萘基，或其盐。
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公开(公告)号：US4719206A
公开(公告)日：1988-01-12
申请号：US824969
申请日：1986-01-31
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D213/20 , C07D401/06 , C07D501/18 , C07D501/24 , A61K31/54
CPC分类号： C07D213/20 , C07D401/06
摘要： The invention relates to novel cephem compounds, of high antimicrobial activity, of the formula: ##STR1## wherein R.sup.1 and R.sup.9 are amino or acylamino; andR.sup.9 is a group of the formula: ##STR2## where R.sup.2 is organic group,X is CH or N,Z is acid residueY is CH or N and n is O; orY is N.sup..sym. --R.sup.2 wherein R.sup.2 is as defined above and n is 1,or a group of the formula:--A--N.sup..sym. (R.sup.10).sub.3whereinR.sup.10 is lower alkyl andA is lower alkylene.
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公开(公告)号：US4594446A
公开(公告)日：1986-06-10
申请号：US690989
申请日：1985-01-14
申请人： Ikuo Ueda , Takao Takaya , Masakazu Kobayashi , Takashi Masugi , Hisashi Takasugi , Hiromu Kochi , Tadashi Kitaguchi
发明人： Ikuo Ueda , Takao Takaya , Masakazu Kobayashi , Takashi Masugi , Hisashi Takasugi , Hiromu Kochi , Tadashi Kitaguchi
IPC分类号： C07D317/30 , C07D319/06 , C07D501/04 , C07D501/14 , C07D501/20 , C07C131/00 , C07D317/14 , C07D321/00 , C07F7/04
CPC分类号： C07D317/30 , C07D319/06
摘要： The invention relates to new antimicrobially active 3-cephem compounds, processes for preparing such compounds, new intermediate compounds comprising alkoxyimino dioxy butyric acid derivatives useful in said processes, and processes for preparation of said intermediates.
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