公开(公告)号：US09468919B2

公开(公告)日：2016-10-18

申请号：US14940643

申请日：2015-11-13

申请人： Takasago International Corporation

发明人： Taichiro Touge ,  Hideki Nara ,  Tomohiko Hakamada

IPC分类号： C07F15/00 ,  C07C303/40 ,  C07C311/20 ,  C07C311/07 ,  C07C311/08 ,  C07C29/145 ,  B01J31/18 ,  C07C29/143 ,  C07C209/52 ,  C07C253/30 ,  C07D307/42 ,  C07D311/22 ,  C07F19/00 ,  B01J31/22

CPC分类号： B01J31/1805 ,  B01J31/2295 ,  B01J2231/326 ,  B01J2231/643 ,  B01J2231/646 ,  B01J2531/0208 ,  B01J2531/821 ,  B01J2540/32 ,  C07C29/143 ,  C07C209/52 ,  C07C253/30 ,  C07D307/42 ,  C07D311/22 ,  C07F15/0046 ,  C07F19/00 ,  H01L2924/0002 ,  H01L2924/00

摘要： Provided is a catalyst for asymmetric reduction, which can be produced by a convenient and safe production method, has a strong catalytic activity, and has excellent stereoselectivity. The present invention relates to a ruthenium complex represented by the following formula (1): wherein R1 represents an alkyl group or the like; Y represents a hydrogen atom; X represents a halogen atom or the like; j and k each represent 0 or 1; R2 and R3 each represent an alkyl group or the like; R11 to R19 each represent a hydrogen atom, an alkyl group or the like; Z represents oxygen or sulfur; n1 represents 1 or 2; and n2 represents an integer from 1 to 3, a method for producing the ruthenium complex, a catalyst for asymmetric reduction formed from the ruthenium complex, and methods for selectively producing an optically active alcohol and an optically active amine using the catalyst for asymmetric reduction.

公开(公告)号：US20160067696A1

公开(公告)日：2016-03-10

申请号：US14940643

申请日：2015-11-13

申请人： Takasago International Corporation

发明人： Taichiro Touge ,  Hideki Nara ,  Tomohiko Hakamada

IPC分类号： B01J31/18 ,  C07C29/143 ,  C07C209/52 ,  C07C253/30 ,  C07D311/22 ,  C07F15/00 ,  C07D307/42

CPC分类号： B01J31/1805 ,  B01J31/2295 ,  B01J2231/326 ,  B01J2231/643 ,  B01J2231/646 ,  B01J2531/0208 ,  B01J2531/821 ,  B01J2540/32 ,  C07C29/143 ,  C07C209/52 ,  C07C253/30 ,  C07D307/42 ,  C07D311/22 ,  C07F15/0046 ,  C07F19/00 ,  H01L2924/0002 ,  H01L2924/00

摘要： Provided is a catalyst for asymmetric reduction, which can be produced by a convenient and safe production method, has a strong catalytic activity, and has excellent stereoselectivity. The present invention relates to a ruthenium complex represented by the following formula (1): wherein R1 represents an alkyl group or the like; Y represents a hydrogen atom; X represents a halogen atom or the like; j and k each represent 0 or 1; R2 and R3 each represent an alkyl group or the like; R11 to R19 each represent a hydrogen atom, an alkyl group or the like; Z represents oxygen or sulfur; n1 represents 1 or 2; and n2 represents an integer from 1 to 3, a method for producing the ruthenium complex, a catalyst for asymmetric reduction formed from the ruthenium complex, and methods for selectively producing an optically active alcohol and an optically active amine using the catalyst for asymmetric reduction.

公开(公告)号：US08987492B2

公开(公告)日：2015-03-24

申请号：US14528053

申请日：2014-10-30

申请人： Takasago International Corporation

发明人： Taichiro Touge ,  Tomohiko Hakamata ,  Hideki Nara

IPC分类号： C07F15/00

CPC分类号： C07F15/0046 ,  B01J31/1805 ,  B01J31/2282 ,  B01J2231/643 ,  B01J2531/0205 ,  B01J2531/0216 ,  B01J2531/821 ,  C07B53/00 ,  C07B2200/07 ,  C07C29/143 ,  C07C41/26 ,  C07C209/52 ,  C07C2602/12 ,  C07D311/22 ,  C07C43/23 ,  C07C33/20 ,  C07C33/18 ,  C07C33/34 ,  C07C33/22 ,  C07C33/46 ,  C07C35/23

摘要： Provided is a ruthenium complex that is represented by general formula (1*) and is useful as an asymmetric reduction catalyst. (In the formula, * is an asymmetric carbon atom; R1 is an arenesulfonyl group, and the like; R2 and R3 are a phenyl group, and the like; R10 through R14 are selected from a hydrogen atom, C1-10 alkyl group, and the like, but R10 through R14 are not simultaneously hydrogen atoms; X is a halogen atom and the like; j and k are each either 0 or 1; and j+k is 0 or 2.)

公开(公告)号：US20140296562A1

公开(公告)日：2014-10-02

申请号：US14352920

申请日：2012-10-31

申请人： TAKASAGO INTERNATIONAL CORPORATION

发明人： Shigeru Tanaka ,  Taichiro Touge ,  Hideki Nara ,  Kenya Ishida

IPC分类号： C07C67/31

CPC分类号： C07C67/31 ,  C07B53/00 ,  C07C231/12 ,  C07C231/18 ,  C07F15/0046 ,  C07C233/47

摘要： The present invention relates to a novel method for producing an optically active β-hydroxy-α-aminocarboxylic acid ester, the method comprising performing an asymmetric reduction reaction of a β-keto-α-aminocarboxylic acid ester by use of a ruthenium complex as a catalyst.

摘要翻译： 本发明涉及一种制备光学活性的α-羟基-α-氨基羧酸酯的新方法，该方法包括使用钌络合物进行α-酮-α-氨基羧酸酯的不对称还原反应 作为催化剂。

公开(公告)号：US09745229B2

公开(公告)日：2017-08-29

申请号：US15117333

申请日：2015-02-13

申请人： TAKASAGO INTERNATIONAL CORPORATION

发明人： Taichiro Touge ,  Hideki Nara

IPC分类号： C07F15/00 ,  C07B53/00 ,  C07D215/06 ,  C07C213/02 ,  C07C217/84 ,  C07D241/42 ,  C07D265/36 ,  C07D209/08 ,  C07D209/80 ,  C07C303/40 ,  C07C311/18 ,  B01J31/18 ,  C07B31/00 ,  C07D209/86 ,  C07D209/94

CPC分类号： C07B53/00 ,  B01J31/1805 ,  B01J2231/641 ,  B01J2531/821 ,  B01J2531/827 ,  C07B31/00 ,  C07C213/02 ,  C07C217/84 ,  C07C303/40 ,  C07C311/18 ,  C07D209/08 ,  C07D209/80 ,  C07D209/86 ,  C07D209/94 ,  C07D215/06 ,  C07D241/42 ,  C07D265/36 ,  C07F15/0033 ,  C07F15/0046

摘要： The present invention pertains to a method for producing an optically active compound which includes a step for reducing an imino group of an imine compound or a step for reducing an unsaturated bond of a heterocyclic compound, while in the presence of hydrogen gas as a hydrogen donor and one or more types of complexes selected from a group consisting of a complex represented by general formula (1), a complex represented by general formula (2), a complex represented by general formula (3), and a complex represented by general formula (4) (the general formulas (1)-(4) are as stipulated by claim 1).

公开(公告)号：US09382280B2

公开(公告)日：2016-07-05

申请号：US14497732

申请日：2014-09-26

申请人： TAKASAGO INTERNATIONAL CORPORATION

发明人： Taichiro Touge

IPC分类号： C07D209/08 ,  C07D215/06 ,  C07D241/42 ,  C07F15/00 ,  B01J31/22 ,  B01J31/18 ,  C07F9/38 ,  C07F17/00

CPC分类号： C07F15/0046 ,  B01J31/1805 ,  B01J31/2295 ,  B01J2231/646 ,  B01J2531/821 ,  B01J2531/827 ,  C07D209/08 ,  C07D215/06 ,  C07D241/42 ,  C07F9/3808 ,  C07F15/0033 ,  C07F17/00

摘要： The present invention relates to a diamine compound represented by the general formula (1), a ruthenium-diamine complex, an iridium-diamine complex, and a rhodium-diamine complex having the diamine compound as a ligand. Furthermore, the present invention relates to methods for selectively producing optically active compounds by using any of these complexes as a catalyst. wherein R1, R2, R3, X, Y, and Z are as defined in claim 1.

摘要翻译： 本发明涉及由通式（1）表示的二胺化合物，钌二胺络合物，铱二胺络合物和具有二胺化合物作为配体的铑 - 二胺络合物。 此外，本发明涉及通过使用这些配合物中的任一种作为催化剂选择性地制备光学活性化合物的方法。 其中R1，R2，R3，X，Y和Z如权利要求1所定义。

公开(公告)号：US08969609B1

公开(公告)日：2015-03-03

申请号：US14528093

申请日：2014-10-30

申请人： Takasago International Corporation

发明人： Taichiro Touge ,  Tomohiko Hakamata ,  Hideki Nara

IPC分类号： C07F15/00

CPC分类号： C07F15/0046 ,  B01J31/1805 ,  B01J31/2282 ,  B01J2231/643 ,  B01J2531/0205 ,  B01J2531/0216 ,  B01J2531/821 ,  C07B53/00 ,  C07B2200/07 ,  C07C29/143 ,  C07C41/26 ,  C07C209/52 ,  C07C2602/12 ,  C07D311/22 ,  C07C43/23 ,  C07C33/20 ,  C07C33/18 ,  C07C33/34 ,  C07C33/22 ,  C07C33/46 ,  C07C35/23

摘要： Provided is a ruthenium complex that is represented by general formula (1*) and is useful as an asymmetric reduction catalyst. (In the formula, * is an asymmetric carbon atom; R1 is an arenesulfonyl group, and the like; R2 and R3 are a phenyl group, and the like; R10 through R14 are selected from a hydrogen atom, C1-10 alkyl group, and the like, but R10 through R14 are not simultaneously hydrogen atoms; X is a halogen atom and the like; j and k are each either 0 or 1; and j+k is 0 or 2.)

摘要翻译： 提供由通式（1 *）表示的钌络合物，可用作不对称还原催化剂。 （式中，*为不对称碳原子，R1为芳烯磺酰基等，R2，R3为苯基等; R10〜R14选自氢原子，C1-10烷基， 但R10至R14不同时为氢原子; X为卤素原子等; j和k各自为0或1; j + k为0或2.）