-
1.发明授权Proline ester and preparation containing the same for percutaneous administration 失效脯氨酸酯和含有相同用于经皮给药的制剂公开(公告)号：US07323489B2
公开(公告)日：2008-01-29
申请号：US10527062
申请日：2003-09-08
IPC分类号： A61K31/40 , C07D207/00
CPC分类号： A61K9/7053 , A61K9/0014 , A61K9/7076 , A61K38/00 , C07K5/0222 , C07K5/06026
摘要： A proline ester represented by the following formula (I): wherein R1 represents a hydroxy-lower alkyl group, a lower alkoxy-lower alkyl group, or a lower alkoxy-lower alkoxy-lower alkyl group or a pharmaceutically acceptable salt thereof. The proline ester (I) of the present invention and a pharmaceutically acceptable salt thereof are useful as a prodrug of enalaprilat, which is a medicine useful for preventing or treating circulatory diseases such as hypertension, cardiac diseases (e.g., cardiac hypertrophy, cardiac failure, and myocardial infarct), nephritis, and apoplexy. Thus, a drug containing the ester or a salt thereof is preferably formulated to a percutaneous preparation, particularly a patch, from the viewpoint of medicinal activity and use.
摘要翻译： 由下式（I）表示的脯氨酸酯：其中R 1表示羟基 - 低级烷基，低级烷氧基 - 低级烷基或低级烷氧基 - 低级烷氧基 - 低级烷基，或 其药学上可接受的盐。 本发明的脯氨酸酯（I）及其药学上可接受的盐可用作依那普利的前药，它是可用于预防或治疗诸如高血压，心脏疾病（例如心脏肥大，心脏衰竭， 和心肌梗塞），肾炎和中风。 因此，从药物活性和用途的观点出发，优选将含有酯或其盐的药剂配制成经皮制剂，特别是贴剂。
-
公开(公告)号：US20070024044A1
公开(公告)日：2007-02-01
申请号：US10574856
申请日：2005-03-29
申请人： Tsutomu Ogawa , Haruyuki Iwasaki , Izuru Hori , Yuichi Nagai , Hiroshi Akiyama , Kunihiko Kimura
发明人： Tsutomu Ogawa , Haruyuki Iwasaki , Izuru Hori , Yuichi Nagai , Hiroshi Akiyama , Kunihiko Kimura
CPC分类号： B60G7/02 , B60G3/20 , B60G2200/144 , B60G2200/4622 , B60G2204/143 , B60G2204/15 , B60G2204/19 , B60G2204/41 , B60G2204/4302 , B60G2206/604 , B60K5/04 , B60K5/12 , B60K17/34 , B62D21/11 , B62D25/082
摘要： A front cross member 202 of a rear subframe 53 has a recessed portion 221 which is recessed continuously over a longitudinal direction thereof. The recessed portion 221 is formed at a lower portion of the cross member 202 and is recessed upwardly, and an elastic bush 240 is fitted in a resulting recess. The elastic bush 240 has an elastic element 243 which connects together an inner tube 241 and an outer tube 242 which surrounds the inner tube 231 and is mounted on the rear subframe 53 at the recessed portion 221 as a bracket. The bracket 221 has bracket plate portions 263a, 263b which each have a plane which is brought into contact with an end face of the inner tube and folded-back portions 235, 235. The bracket 221 is disposed in such a manner as to hold therein both ends of the inner tube 241 and is configured such that the elastic bush 240 is mounted thereon by passing a bolt 224 through the inner tube 241.
摘要翻译： 后副车架53的前横梁202具有在其纵向方向上连续凹陷的凹部221。 凹部221形成在横构件202的下部并向上凹入，并且弹性衬套240装配在所得到的凹部中。 弹性衬套240具有弹性元件243，该弹性元件243将内管241和围绕内管231的外管242连接在一起，并且作为支架在作为凹部221安装在后副框53上。 支架221具有托架板部263a，263b，每个托架板部分具有与内管的端面和折回部分235,235接触的平面。 支架221设置成保持在内管241的两端，并且通过使螺栓224穿过内管241而使弹性衬套240安装在其上。
-
公开(公告)号：US20100163446A1
公开(公告)日：2010-07-01
申请号：US12303759
申请日：2007-06-26
申请人： Toyoaki Suzuki , Koichi Miura , Akemi Kishimoto , Kunihiko Kimura , Yoshikazu Kato , Yukie Ito
发明人： Toyoaki Suzuki , Koichi Miura , Akemi Kishimoto , Kunihiko Kimura , Yoshikazu Kato , Yukie Ito
CPC分类号： B65D31/02 , A61J1/10 , B32B27/32 , B32B27/325 , B32B2439/00 , Y10T428/1341
摘要： To provide a liquid container, which exhibits excellent storage stability and impact resistance and which can be used for producing a soft bag pharmaceutical product of an injection liquid containing nitroglycerin, a protein, hyaluronic acid, a vitamin, a trace element, a radical scavenger, and the like.The liquid container of the invention formed of a multilayer film and/or multilayer sheet, characterized in that the multilayer film and/or multilayer sheet has a barrier layer containing, as a predominant component, a polycycloolefin-based resin having a glass transition temperature higher by 5° C. or more than the temperature at which the container is subjected to thermal treatment or high-pressure steam sterilization, and a seal layer containing, as a predominant component, a polyethylene-based resin or a polypropylene-based resin, and the barrier layer being provided adjacent to the seal layer.
摘要翻译： 本发明提供一种储存稳定性和耐冲击性优异的液体容器，其能够用于生产含有硝酸甘油，蛋白质，透明质酸，维生素，微量元素，自由基清除剂的注射液的软袋药物， 等等。 本发明的液体容器由多层薄膜和/或多层薄片形成，其特征在于，多层薄膜和/或多层薄片具有阻挡层，该阻挡层含有玻璃化转变温度较高的聚环烯烃系树脂作为主要成分 比容器进行热处理或高压蒸汽灭菌的温度高5℃或以上，以及包含聚乙烯类树脂或聚丙烯类树脂作为主要成分的密封层，以及 所述阻挡层邻近所述密封层设置。
-
公开(公告)号：US20090322050A1
公开(公告)日：2009-12-31
申请号：US12491862
申请日：2009-06-25
申请人： Tsutomu Ogawa , Haruyuki Iwasaki , Izuru Hori , Yuichi Nagai , Hiroshi Akiyama , Kunihiko Kimura
发明人： Tsutomu Ogawa , Haruyuki Iwasaki , Izuru Hori , Yuichi Nagai , Hiroshi Akiyama , Kunihiko Kimura
IPC分类号： B62D21/11
CPC分类号： B60G7/02 , B60G3/20 , B60G2200/144 , B60G2200/4622 , B60G2204/143 , B60G2204/15 , B60G2204/19 , B60G2204/41 , B60G2204/4302 , B60G2206/604 , B60K5/04 , B60K5/12 , B60K17/34 , B62D21/11 , B62D25/082
摘要： A front cross member 202 of a rear subframe 53 has a recessed portion 221 which is recessed continuously over a longitudinal direction thereof. The recessed portion 221 is formed at a lower portion of the cross member 202 and is recessed upwardly, and an elastic bush 240 is fitted in a resulting recess. The elastic bush 240 has an elastic element 243 which connects together an inner tube 241 and an outer tube 242 which surrounds the inner tube 231 and is mounted on the rear subframe 53 at the recessed portion 221 as a bracket. The bracket 221 has bracket plate portions 263a, 263b which each have a plane which is brought into contact with an end face of the inner tube and folded-back portions 235, 235. The bracket 221 is disposed in such a manner as to hold therein both ends of the inner tube 241 and is configured such that the elastic bush 240 is mounted thereon by passing a bolt 224 through the inner tube 241.
摘要翻译： 后副车架53的前横梁202具有在其纵向方向上连续凹陷的凹部221。 凹部221形成在横构件202的下部并向上凹入，并且弹性衬套240装配在所得到的凹部中。 弹性衬套240具有弹性元件243，该弹性元件243将内管241和围绕内管231的外管242连接在一起，并且作为支架在作为凹部221安装在后副框53上。 支架221具有支架板部分263a，263b，每个支架板部分具有与内管的端面和折回部分235,235接触的平面。托架221以保持在其中的方式设置 内管241的两端，通过使螺栓224穿过内管241，使弹性衬套240安装在其上。
-
公开(公告)号：US07584815B2
公开(公告)日：2009-09-08
申请号：US10574856
申请日：2005-03-29
申请人： Tsutomu Ogawa , Haruyuki Iwasaki , Izuru Hori , Yuichi Nagai , Hiroshi Akiyama , Kunihiko Kimura
发明人： Tsutomu Ogawa , Haruyuki Iwasaki , Izuru Hori , Yuichi Nagai , Hiroshi Akiyama , Kunihiko Kimura
IPC分类号： B62D21/12
CPC分类号： B60G7/02 , B60G3/20 , B60G2200/144 , B60G2200/4622 , B60G2204/143 , B60G2204/15 , B60G2204/19 , B60G2204/41 , B60G2204/4302 , B60G2206/604 , B60K5/04 , B60K5/12 , B60K17/34 , B62D21/11 , B62D25/082
摘要： A front cross member 202 of a rear subframe 53 has a recessed portion 221 which is recessed continuously over a longitudinal direction thereof. The recessed portion 221 is formed at a lower portion of the cross member 202 and is recessed upwardly, and an elastic bush 240 is fitted in a resulting recess. The elastic bush 240 has an elastic element 243 which connects together an inner tube 241 and an outer tube 242 which surrounds the inner tube 231 and is mounted on the rear subframe 53 at the recessed portion 221 as a bracket. The bracket 221 has bracket plate portions 263a, 263b which each have a plane which is brought into contact with an end face of the inner tube and folded-back portions 235, 235. The bracket 221 is disposed in such a manner as to hold therein both ends of the inner tube 241 and is configured such that the elastic bush 240 is mounted thereon by passing a bolt 224 through the inner tube 241.
摘要翻译： 后副车架53的前横梁202具有在其纵向方向上连续凹陷的凹部221。 凹部221形成在横构件202的下部并向上凹入，并且弹性衬套240装配在所得到的凹部中。 弹性衬套240具有弹性元件243，该弹性元件243将内管241和围绕内管231的外管242连接在一起，并且作为支架在作为凹部221安装在后副框53上。 支架221具有支架板部分263a，263b，每个支架板部分具有与内管的端面和折回部分235,235接触的平面。托架221以保持在其中的方式设置 内管241的两端，通过使螺栓224穿过内管241，使弹性衬套240安装在其上。
-
公开(公告)号：US07845662B2
公开(公告)日：2010-12-07
申请号：US12491862
申请日：2009-06-25
申请人： Tsutomu Ogawa , Haruyuki Iwasaki , Izuru Hori , Yuichi Nagai , Hiroshi Akiyama , Kunihiko Kimura
发明人： Tsutomu Ogawa , Haruyuki Iwasaki , Izuru Hori , Yuichi Nagai , Hiroshi Akiyama , Kunihiko Kimura
IPC分类号： B62D21/11
CPC分类号： B60G7/02 , B60G3/20 , B60G2200/144 , B60G2200/4622 , B60G2204/143 , B60G2204/15 , B60G2204/19 , B60G2204/41 , B60G2204/4302 , B60G2206/604 , B60K5/04 , B60K5/12 , B60K17/34 , B62D21/11 , B62D25/082
摘要： A front cross member 202 of a rear subframe 53 has a recessed portion 221 which is recessed continuously over a longitudinal direction thereof. The recessed portion 221 is formed at a lower portion of the cross member 202 and is recessed upwardly, and an elastic bush 240 is fitted in a resulting recess. The elastic bush 240 has an elastic element 243 which connects together an inner tube 241 and an outer tube 242 which surrounds the inner tube 231 and is mounted on the rear subframe 53 at the recessed portion 221 as a bracket. The bracket 221 has bracket plate portions 263a, 263b which each have a plane which is brought into contact with an end face of the inner tube and folded-back portions 235, 235. The bracket 221 is disposed in such a manner as to hold therein both ends of the inner tube 241 and is configured such that the elastic bush 240 is mounted thereon by passing a bolt 224 through the inner tube 241.
摘要翻译： 后副车架53的前横梁202具有在其纵向方向上连续凹陷的凹部221。 凹部221形成在横构件202的下部并向上凹入，并且弹性衬套240装配在所得到的凹部中。 弹性衬套240具有弹性元件243，该弹性元件243将内管241和围绕内管231的外管242连接在一起，并且作为支架在作为凹部221安装在后副框53上。 支架221具有支架板部分263a，263b，每个支架板部分具有与内管的端面和折回部分235,235接触的平面。托架221以保持在其中的方式设置 内管241的两端，通过使螺栓224穿过内管241，使弹性衬套240安装在其上。
-
公开(公告)号：US07513491B2
公开(公告)日：2009-04-07
申请号：US11199788
申请日：2005-08-09
申请人： Tsutomu Ogawa , Kunihiko Kimura , Shuichi Ono , Eiji Yamada
发明人： Tsutomu Ogawa , Kunihiko Kimura , Shuichi Ono , Eiji Yamada
IPC分类号： F16F15/00
CPC分类号： F16F13/149
摘要： An engine mount system includes multiple liquid-filled engine mounts switchable to provide different mount characteristics by selectively introducing negative pressure or atmospheric pressure. On one of pipelines connected to the respective engine mounts for introducing the negative or atmospheric pressure into the respective engine mounts, a check valve and an orifice portion are provided in parallel. The orifice portion restricts an amount of air flowing therethrough, so that the mount characteristic of the engine mount connected to the one pipeline equipped with the check valve and the orifice portion does not undergo an abrupt change when the pressure introduced in the engine mount is switched from the negative pressure to the atmospheric pressure.
摘要翻译： 发动机安装系统包括多个充满液体的发动机支架，其可通过选择性地引入负压或大气压来切换以提供不同的安装特性。 在连接到相应的发动机支架的管道之一中，用于将负压或大气压力引入相应的发动机支架中，并联设置止回阀和孔口部分。 孔口部分限制了流过其中的空气量，使得当连接到配备有止回阀和孔口部分的一个管道的发动机支架的安装特性在被引入发动机支架中的压力被切换时不会发生突然变化 从负压到大气压。
-
公开(公告)号：US20070169982A1
公开(公告)日：2007-07-26
申请号：US10588002
申请日：2005-03-29
申请人： Tsutomu Ogawa , Kunihiko Kimura , Fumiaki Fukuchi , Shuichi Ono , Shuji Otake , Yasunori Oku , Hideki Koga
发明人： Tsutomu Ogawa , Kunihiko Kimura , Fumiaki Fukuchi , Shuichi Ono , Shuji Otake , Yasunori Oku , Hideki Koga
CPC分类号： B60G3/20 , B60G2200/144 , B60G2204/143 , B60G2204/15 , B62D21/11 , B62D25/082
摘要： A front subframe 42 is formed of an aluminum alloy into a frame that is formed substantially into a shape of parallel crosses or into a rectangular shape and is made up of left and right front joint portions 64, 64 and left and right rear joint portions 71, 71 which are disposed at corners of the frame that is formed substantially into the shape of parallel crosses or the rectangular shape, and left and right longitudinal members 61, 61, and front and rear cross members 62, 67 which connect the joint portions 64, 64, 71, 71 together. The left and right front joint portions 64, 64 and the left and right rear joint portions 71, 71 are formed of an aluminum alloy die-cast product, whereas the left and right longitudinal members 61, 61 are formed of an aluminum alloy wrought product. In addition, connecting locations 76 . . . of a camber angle adjusting mechanism 157 are formed of an aluminum alloy die-cast product. Additionally, a rear cross member compound 63 is formed of an aluminum alloy die-cast product.
摘要翻译： 前副车架42由铝合金形成为基本上形成为平行十字形或矩形形状的框架，并且由左右前连接部64,64以及左右前连接部71 71，其设置在基本上形成为平行十字形或矩形形状的框架的角部;以及左右纵向构件61,61以及连接接合部64的前后横向构件62,67 ，64,71,71。 左右前侧接合部64,64以及左右后侧接合部71,71由铝合金压铸体形成，左右纵向构件61,61由铝合金锻造品 。 另外，连接位置76。 。 。 外倾角调节机构157由铝合金压铸产品形成。 此外，后横向构件化合物63由铝合金压铸产品形成。
-
公开(公告)号：US07520514B2
公开(公告)日：2009-04-21
申请号：US10588002
申请日：2005-03-29
申请人： Tsutomu Ogawa , Kunihiko Kimura , Fumiaki Fukuchi , Shuichi Ono , Shuji Otake , Yasunori Oku , Hideki Koga
发明人： Tsutomu Ogawa , Kunihiko Kimura , Fumiaki Fukuchi , Shuichi Ono , Shuji Otake , Yasunori Oku , Hideki Koga
IPC分类号： B62D21/11
CPC分类号： B60G3/20 , B60G2200/144 , B60G2204/143 , B60G2204/15 , B62D21/11 , B62D25/082
摘要： A front subframe 42 is formed of an aluminum alloy into a frame that is formed substantially into a shape of parallel crosses or into a rectangular shape and is made up of left and right front joint portions 64, 64 and left and right rear joint portions 71, 71 which are disposed at corners of the frame that is formed substantially into the shape of parallel crosses or the rectangular shape, and left and right longitudinal members 61, 61, and front and rear cross members 62, 67 which connect the joint portions 64, 64, 71, 71 together. The left and right front joint portions 64, 64 and the left and right rear joint portions 71, 71 are formed of an aluminum alloy die-cast product, whereas the left and right longitudinal members 61, 61 are formed of an aluminum alloy wrought product. In addition, connecting locations 76 . . . of a camber angle adjusting mechanism 157 are formed of an aluminum alloy die-cast product. Additionally, a rear cross member compound 63 is formed of an aluminum alloy die-cast product.
摘要翻译： 前副车架42由铝合金形成为基本上形成为平行十字形或矩形形状的框架，并且由左右前连接部64,64以及左右前连接部71 71，其设置在基本上形成为平行十字形或矩形形状的框架的角部;以及左右纵向构件61,61以及连接接合部64的前后横向构件62,67 ，64,71,71。 左右前侧接合部64,64以及左右后侧接合部71,71由铝合金压铸体形成，左右纵向构件61,61由铝合金锻造品 。 另外，连接位置76。 。 。 外倾角调节机构157由铝合金压铸产品形成。 此外，后横向构件化合物63由铝合金压铸产品形成。
-
公开(公告)号：US20060038331A1
公开(公告)日：2006-02-23
申请号：US11199788
申请日：2005-08-09
申请人： Tsutomu Ogawa , Kunihiko Kimura , Shuichi Ono , Eiji Yamada
发明人： Tsutomu Ogawa , Kunihiko Kimura , Shuichi Ono , Eiji Yamada
IPC分类号： F16F15/00
CPC分类号： F16F13/149
摘要： An engine mount system includes multiple liquid-filled engine mounts switchable to provide different mount characteristics by selectively introducing negative pressure or atmospheric pressure. On one of pipelines connected to the respective engine mounts for introducing the negative or atmospheric pressure into the respective engine mounts, a check valve and an orifice portion are provided in parallel. The orifice portion restricts an amount of air flowing therethrough, so that the mount characteristic of the engine mount connected to the one pipeline equipped with the check valve and the orifice portion does not undergo an abrupt change when the pressure introduced in the engine mount is switched from the negative pressure to the atmospheric pressure.
-
-
-
-
-
-
-
-
-
搜索结果
10 条记录 (耗时 0.024 秒)
