公开(公告)号：US06678399B2

公开(公告)日：2004-01-13

申请号：US09990311

申请日：2001-11-23

申请人： Kunio Doi ,  Takayuki Ishida ,  Shigehiko Katsuragawa

发明人： Kunio Doi ,  Takayuki Ishida ,  Shigehiko Katsuragawa

IPC分类号： G06K900

CPC分类号： G06T5/30 ,  G06T5/50 ,  G06T7/11 ,  G06T2207/10081 ,  G06T2207/20224 ,  G06T2207/30064

摘要： A method, system, computer readable medium and apparatus for computerized detection of lung nodules in computer tomography images, by which mask images are created such that subtractions of the mask image from a targeted CT section image reveal or highlight small lung nodules in the target CT section. The mask image is created utilizing the targeted CT section image along with other CT section images generated from the same CT scan. Based on these other section CT images and the targeted CT section image, a mask image can be created that is very similar to the target CT section image, but without the presence of small lung nodules. When the mask image is subtracted from the targeted CT section image, the differences between the mask images and the CT section images reveal small lung nodules. The mask image may be created by linear interpolation or a morphological filtered image.

摘要翻译： 一种用于计算机化检测计算机断层摄影图像中的肺结节的方法，系统，计算机可读介质和装置，通过该方法创建掩模图像，使得来自目标CT部分图像的掩模图像的减法显示或突出显示目标CT中的小肺结节 部分。 使用目标CT部分图像以及从相同CT扫描生成的其他CT部分图像创建掩模图像。 基于这些其他部分CT图像和目标CT部分图像，可以创建与目标CT部分图像非常相似但不存在小肺结节的掩模图像。 当从目标CT部分图像中减去掩模图像时，掩模图像和CT部分图像之间的差异显示出小的肺结节。 掩模图像可以通过线性内插或形态滤波图像来创建。

公开(公告)号：US07043066B1

公开(公告)日：2006-05-09

申请号：US09830562

申请日：1999-11-05

申请人： Kunio Doi ,  Qiang Li ,  Shigehiko Katsuragawa ,  Takayuki Ishida

发明人： Kunio Doi ,  Qiang Li ,  Shigehiko Katsuragawa ,  Takayuki Ishida

IPC分类号： G06K9/00

CPC分类号： G06T5/50 ,  G06T7/0012 ,  G06T7/11 ,  G06T7/174 ,  G06T7/33 ,  G06T2207/10116 ,  G06T2207/20224 ,  G06T2207/30064

摘要： A method, system and computer readable medium for computerized processing of chest images including obtaining a digital first image of a chest (S100); producing a second image which is a mirror image (S300) of the first image; performing image warping on one of the first and second images to produce a warped image (S400) which is registered to the other of the first and second images; and subtracting the warped image from the other image to generate a subtraction image (S600). Another embodiment includes obtaining a digital first image of the chest of a subject; detecting ribcage edges on both sides of the lungs in the first chest image; determining average horizontal locations of the left and right ribcage edges at plural vertical locations; fitting the determined average horizontal locations to a straight line to derive a midline; rotating the chest image so that the midline is vertical; and shifting the rotated image to produce a lateral inclination corrected (S200) second image with the midline centered in the lateral inclination corrected image.

摘要翻译： 一种用于胸部图像的计算机化处理的方法，系统和计算机可读介质，包括获得胸部的数字第一图像（S100）; 产生作为第一图像的镜像（S 300）的第二图像; 在第一和第二图像之一上执行图像扭曲以产生被注册到第一和第二图像中的另一个的翘曲图像（S 400）; 以及从所述另一图像中减去所述翘曲图像以生成减法图像（S 600）。 另一实施例包括获得对象胸部的数字第一图像; 在第一胸部图像中检测肺两侧的肋骨边缘; 确定在多个垂直位置处的左和右胸腔边缘的平均水平位置; 将确定的平均水平位置拟合到直线以导出中线; 旋转胸部图像，使中线垂直; 并且移动旋转的图像以产生以横向倾斜校正图像为中心的中线的横向倾斜校正（S 200）第二图像。

公开(公告)号：US6067373A

公开(公告)日：2000-05-23

申请号：US53798

申请日：1998-04-02

申请人： Takayuki Ishida ,  Shigehiko Katsuragawa ,  Kunio Doi

发明人： Takayuki Ishida ,  Shigehiko Katsuragawa ,  Kunio Doi

IPC分类号： A61B6/00 ,  G01N20060101 ,  G06K9/00 ,  G06K9/80 ,  G06T1/00 ,  G06T3/00 ,  G06T5/40 ,  G06T7/00 ,  G06T7/20 ,  H04N5/325

CPC分类号： G06T7/2053 ,  G06T3/0068 ,  G06T7/0016 ,  G06T7/003 ,  G06T2207/30061

摘要： A method of computerized analysis of temporally sequential digital images, including (a) determining first shift values between pixels of a first digital image and corresponding pixels of a second digital image; (b) warping the second digital image based on the first shift values to obtain a first warped image in which spatial locations of pixels are varied in relation to the first shift values; (c) determining second shift values between pixels of the first digital image and pixels of the first warped image; and (d) warping the first warped image based on the second shift values to obtain a second warped image in which spatial locations of pixels of the first warped image are varied in relation to the second shift values. Additional iterations of image warping are possible to enhance image registration between the first digital image and the warped version of the second digital image, followed by image subtraction of the first digital image and the final warped image to produce a difference image from which diagnosis of temporal changes ensues. Temporal subtraction assists radiologists in the detection of interval changes on chest radiographs, and particularly to overcome severe misregistration errors in the temporally sequential images mainly due to differences in a subject's inclination and/or rotation. In the production of shift values used in image warping, initial shift values are obtained by cross-correlation techniques using a template and search regions of interest. Shift vectors and a histogram of shift vectors in each lung are obtained from initial shift values. The histograms of shift vectors are used in the selection of sets of shift values for smoothing, using two-dimensional fitting and subsequent use of fitted shift values in image warping.

摘要翻译： 一种对时间顺序数字图像进行计算机化分析的方法，包括：（a）确定第一数字图像的像素与第二数字图像的对应像素之间的第一移位值; （b）基于第一移位值对第二数字图像进行翘曲以获得其中像素的空间位置相对于第一移位值变化的第一翘曲图像; （c）确定第一数字图像的像素与第一翘曲图像的像素之间的第二移位值; 以及（d）基于第二偏移值对第一翘曲图像进行翘曲以获得其中第一翘曲图像的像素的空间位置相对于第二偏移值变化的第二扭曲图像。 图像翘曲的附加迭代可以增强第一数字图像和第二数字图像的翘曲版本之间的图像配准，随后是第一数字图像和最终的扭曲图像的图像相减，以产生从其中诊断时间的差分图像 发生变化。 时间减法协助放射科医生检测胸片间期变化，特别是克服主要由于受试者的倾斜度和/或旋转方面的差异而导致的时间顺序图像中的严重重合错误。 在图像变形中使用的位移值的生成中，通过使用模板和感兴趣的搜索区域的互相关技术来获得初始偏移值。 从初始位移值获得每个肺中的移位向量和移位向量的直方图。 移位矢量的直方图用于选择用于平滑的移位值集合，使用二维拟合和随后在图像扭曲中使用拟合的移位值。

公开(公告)号：US5982915A

公开(公告)日：1999-11-09

申请号：US900362

申请日：1997-07-25

申请人： Kunio Doi ,  Takayuki Ishida ,  Shigehiko Katsuragawa

发明人： Kunio Doi ,  Takayuki Ishida ,  Shigehiko Katsuragawa

IPC分类号： A61B6/00 ,  G06T1/00 ,  G06T3/00 ,  G06T5/50 ,  G06T7/00 ,  G06T7/60 ,  G06K9/00

CPC分类号： G06T7/003 ,  G06T3/0081 ,  G06T5/50 ,  G06T7/0016 ,  G06T7/2053 ,  G06T2207/10116 ,  G06T2207/30061

摘要： A method and computerized automated initial image matching technique for enhancing detection of interval changes between temporally subsequent radiographic images via image subtraction. The method includes the steps of digitizing images, normalizing density and contrast in the digital images, correcting for lateral inclination in the digital images, detecting edges of a same feature in each image, converting the images into low resolution matrices, blurring the low resolution images, segmenting portions of the blurred low resolution matrices based on the detected edges, matching the digital images based on a cross-correlation match between the segmented portions, performing non-linear warping to further match Regions of Interest (ROI), and performing image subtraction between the matched digital images. The low resolution matrices are greater than 64.times.64 in size and are produced by averaging. Blurring of the low resolution matrices is performed via a Gaussian filter that removes fine structures in each image such as small vessels, bronchia, etc. The method may be performed by a computer system according to instructions stored on a computer readable medium.

摘要翻译： 一种方法和计算机化的自动初始图像匹配技术，用于通过图像减法增强时间上随后的放射照相图像之间的间隔变化的检测。 该方法包括数字化图像数字化，标准化数字图像中的浓度和对比度，校正数字图像中的横向倾斜，检测每个图像中相同特征的边缘，将图像转换成低分辨率矩阵，模糊低分辨率图像 基于检测到的边缘对模糊的低分辨率矩阵的部分进行分割，基于分段部分之间的互相关匹配匹配数字图像，执行非线性翘曲以进一步匹配感兴趣区域（ROI），并执行图像相减 在匹配的数字图像之间。 低分辨率矩阵大小大于64x64，并通过平均生成。 通过高斯滤波器执行低分辨率矩阵的模糊，其去除每个图像中的精细结构，例如小血管，支气管等。该方法可以由计算机系统根据存储在计算机可读介质上的指令来执行。

公开(公告)号：US5873824A

公开(公告)日：1999-02-23

申请号：US758438

申请日：1996-11-29

申请人： Kunio Doi ,  Takayuki Ishida ,  Shigehiki Katsuragwa

发明人： Kunio Doi ,  Takayuki Ishida ,  Shigehiki Katsuragwa

IPC分类号： A61B5/00 ,  G06F15/18 ,  G06N3/00 ,  G06Q50/00 ,  G06T1/00 ,  G06T7/00

CPC分类号： G06K9/00 ,  G06T7/0012 ,  G06K2209/05 ,  Y10S128/925

摘要： An automated computer-aided diagnosis (CAD) method and system using artificial neural networks (ANNs) for the quantitative analysis of image data. Three separate ANNs were applied for detection of interstitial disease on digitized two-dimensional chest images. The first ANN was trained with horizontal profiles in regions of interest (ROIs) selected from normal and abnormal chest radiographs. The second ANN was trained using vertical output patterns obtained from the 1.sup.st ANN for each ROI. The output value of the 2.sup.nd ANN was used to distinguish between normal and abnormal ROIS with interstitial infiltrates. If the ratio of the number of abnormal ROIs to the total number of all ROIs in a chest image was greater than a certain threshold level, the chest image was considered abnormal. In addition, the third ANN was applied to distinguish between normal and abnormal chest images where the chest image was not clearly normal or abnormal. The ANN trained with image data learns some statistical properties associated with interstitial infiltrates in chest radiographs. In addition, the same technique can be applied to higher-dimensional data (e.g., three-dimensional data and four-dimensional data including time-varying three-dimensional data).

摘要翻译： 一种使用人工神经网络（ANN）进行图像数据定量分析的自动化计算机辅助诊断（CAD）方法和系统。 应用三个独立的ANN来检测数字化二维胸部图像上的间质性疾病。 在正常和异常的胸片中选择感兴趣区域（ROI）中的第一个ANN进行了水平剖面的训练。 使用从每个投资回报率的第一ANN获得的垂直输出模式训练第二ANN。 第二ANN的输出值用于区分正常和异常的ROIS与间质浸润。 如果胸部图像中异常ROI的数量与所有ROI的总数之比大于某一阈值水平，则胸部图像被认为是异常的。 另外，第三个ANN应用于区分胸部图像不正常或异常的正常和异常胸部图像。 用图像数据训练的ANN学习了与胸部X光片中的间质浸润相关的一些统计特性。 此外，相同的技术可以应用于高维数据（例如，三维数据和包括时变三维数据的四维数据）。

公开(公告)号：US20140155442A1

公开(公告)日：2014-06-05

申请号：US14129890

申请日：2012-07-06

申请人： Takayuki Ishida ,  Hiroyuki Kawano

发明人： Takayuki Ishida ,  Hiroyuki Kawano

IPC分类号： A61K31/232 ,  A61K45/06 ,  A61K31/202

CPC分类号： A61K31/232 ,  A61K31/167 ,  A61K31/202 ,  A61K31/421 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention provides an agent for preventing the increase in a body weight (or for decreasing a body weight) or an anti-obesity agent each comprising at least one component selected from the group consisting of EPA and pharmaceutically acceptable salts, esters and derivatives thereof as an active ingredient for obesity in which the increase in the formation of hepatic lipid or the occurrence of fatty liver is mild, preferably the increase in the formation of hepatic lipid or the occurrence of fatty liver is not observed.

摘要翻译： 本发明提供一种用于防止体重增加（或降低体重）的药剂或抗肥胖剂，其各自包含至少一种选自EPA及其药学上可接受的盐，酯和衍生物的组分 作为肥胖的活性成分，其中肝脏脂质形成的增加或脂肪肝的发生是轻度的，优选没有观察到肝脏脂质形成的增加或脂肪肝的发生。

公开(公告)号：US20100169782A1

公开(公告)日：2010-07-01

申请号：US12278830

申请日：2006-11-22

申请人： Masayuki Chatani ,  Hirotoshi Maegawa ,  Takayuki Ishida

发明人： Masayuki Chatani ,  Hirotoshi Maegawa ,  Takayuki Ishida

IPC分类号： G06F3/048 ,  G06F3/01

CPC分类号： G06F3/04815 ,  G11B27/34

摘要： To facilitate finding of content or a service suitable for a user from a large amount of content sets and services. An image of a virtual three dimensional space (16) where a plurality of display elements (14) associated with respective content sets and/or services are placed is shown, and the user moves a designated position (10) in the virtual three dimensional space (16). Then, one or more display elements (14) are selected, based on the designated position (10), and a degree of relevance between user information and attribute information about each content, and associated content and/or service is presented.

摘要翻译： 为了便于从大量内容集和服务中找到适合用户的内容或服务。 示出了其中放置与各个内容集合和/或服务相关联的多个显示元素（14）的虚拟三维空间（16）的图像，并且用户移动虚拟三维空间中的指定位置（10） （16）。 然后，基于所指定的位置（10）选择一个或多个显示元件（14），并且呈现用户信息与关于每个内容的属性信息以及相关联的内容和/或服务之间的相关程度。

公开(公告)号：US07552188B2

公开(公告)日：2009-06-23

申请号：US11356934

申请日：2006-02-21

申请人： Hiroki Kato ,  Hirotoshi Maegawa ,  Takayuki Ishida

发明人： Hiroki Kato ,  Hirotoshi Maegawa ,  Takayuki Ishida

IPC分类号： G06F15/167

CPC分类号： H04L67/38 ,  A63F13/12 ,  A63F13/335 ,  A63F2300/407 ,  A63F2300/5513 ,  A63F2300/5526 ,  H04L12/1813

摘要： On at least one of computers constituting a plurality of nodes on a network N, a management information file representing links between nodes is stored. The computer of each node stores, into a predetermined memory area on the network, digital information pieces generated on the computer. The computer sends the stored digital information pieces to the network N, in response to a request from another computer. The computer which issued the request obtains, from the network N, the sent digital information pieces and the management information file and visualizes the obtained digital information pieces in a view particular thereto; the visualization is carried out on the basis of relations between the request-issuing computer node and the computer node storing the obtained digital information pieces, wherein the relations are identified by the use of the management information file.

摘要翻译： 在构成网络N上的多个节点的计算机的至少一个上，存储表示节点之间的链路的管理信息文件。 每个节点的计算机将在计算机上生成的数字信息存储在网络上的预定存储区域中。 计算机响应于来自另一计算机的请求将存储的数字信息片段发送到网络N。 发出请求的计算机从网络N获得所发送的数字信息和管理信息文件，并且在特定的视图中可视化获得的数字信息片; 基于请求发行计算机节点和存储所获得的数字信息的计算机节点之间的关系进行可视化，其中通过使用管理信息文件来识别关系。

公开(公告)号：US20070097131A1

公开(公告)日：2007-05-03

申请号：US11265112

申请日：2005-11-03

申请人： Takayuki Ishida

发明人： Takayuki Ishida

IPC分类号： G06T1/00

CPC分类号： G06F3/14 ,  G09G3/2092

摘要： In an inventive display and operation device, unit data to be transferred at a time for data transmission from the main body (2) to the display and operation portion (3) differs in size from unit data to be transferred at a time for data transmission from the display and operation portion (3) to the main body (2). More specifically, the unit data for the data transmission from the main body (2) to the display and operation portion (3) has a size of, for example, 16 bytes, while the unit data for the data transmission from the display and operation portion (3) to the main body (2) has a size of, for example, 1 byte. Thus, the size of the unit data for the data transmission from the main body (2) to the display and operation portion (3) is set suitably for transmission of image data, and the size of the unit data for the data transmission from the display and operation portion (3) to the main body (2) is set suitably for transmission of a key input signal.

摘要翻译： 在本发明的显示和操作装置中，要从主体（2）到显示和操作部分（3）的数据传输一次要传送的单元数据在数据传输时与尺寸不同，要传送的单位数据 从显示和操作部分（3）到主体（2）。 更具体地，用于从主体（2）到显示和操作部分（3）的数据传输的单位数据具有例如16字节的大小，而用于从显示和操作的数据传输的单位数据 主体（2）的部分（3）具有例如1字节的大小。 因此，用于从主体（2）到显示和操作部分（3）的数据传输的单位数据的大小被适当地设置用于图像数据的传输，并且用于从 显示和操作部分（3）到主体（2）被适当地设置用于传送键输入信号。

公开(公告)号：US06965725B1

公开(公告)日：2005-11-15

申请号：US09712589

申请日：2000-11-14

申请人： Takahiro Ichikawa ,  Takayuki Ishida ,  Yoshinori Shimizu

发明人： Takahiro Ichikawa ,  Takayuki Ishida ,  Yoshinori Shimizu

IPC分类号： H04N5/76 ,  G11B20/10 ,  H04N5/783 ,  H04N5/85 ,  H04N5/92 ,  H04N5/93 ,  H04N9/804 ,  H04N9/877 ,  H04N9/888 ,  H04N5/91

CPC分类号： H04N5/783 ,  H04N5/85 ,  H04N9/8042 ,  H04N9/877 ,  H04N9/888

摘要： The objectives of the present invention are to reduce the throughput required for a rapid reproduction or other special types of reproduction and to improve also the data access speed at the time of a rapid reproduction. In order to achieve these objectives, the system controller 19 controls so that the address information of the MPEG data reproduced by a pickup 2 may be used to create the first reproduction control information at a sector detection circuit 4, that the second reproduction control information corresponding to the starting point of pictures contained in the MPEG data destined to be reproduction signals by the first reproduction control signal and subjected to an error correction in an error correction circuit 7 may be created in a stream detection circuit 9, and that some MPEG data out of the entire MPEG data may be outputted for a rapid reproduction by referring to the second reproduction control information, and through these steps, the interval of reproducing I pictures in a rapid reproduction by using for example only I pictures is reduced and a smooth reproduction is achieved.

摘要翻译： 本发明的目的是降低快速再现或其他特殊类型的再现所需的吞吐量，并且还可以在快速再现时提高数据访问速度。 为了实现这些目的，系统控制器19控制，使得由拾取器2再现的MPEG数据的地址信息可以用于在扇区检测电路4创建第一再现控制信息，第二再现控制信息对应 可以在流检测电路9中创建包含在由第一再现控制信号指定为再现信号并在纠错电路7中进行纠错的MPEG数据的起始点，并且可以在流检测电路9中创建一些MPEG数据输出 可以通过参考第二再现控制信息输出整个MPEG数据以进行快速再现，并且通过这些步骤，通过仅使用I图像而在快速再现中再现I图像的间隔减少，并且平滑再现是 实现了