利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

25 条记录 (耗时 0.039 秒)

    Sulfoquinovosylacylglycerol derivative, and use thereof as medicaments
    4.
    发明授权
    Sulfoquinovosylacylglycerol derivative, and use thereof as medicaments 失效
    磺基喹诺酮酰基甘油衍生物及其作为药物的用途

    公开(公告)号：US06518410B2

    公开(公告)日：2003-02-11

    申请号：US09949907

    申请日：2001-09-10

    申请人： Takayuki Yamazaki ,  Fumio Sugawara ,  Keisuke Ohta ,  Kazuyoshi Masaki ,  Kotaro Nakayama ,  Kengo Sakaguchi ,  Noriyuki Sato ,  Hiroeki Sahara ,  Tatsuya Fujita

    发明人： Takayuki Yamazaki ,  Fumio Sugawara ,  Keisuke Ohta ,  Kazuyoshi Masaki ,  Kotaro Nakayama ,  Kengo Sakaguchi ,  Noriyuki Sato ,  Hiroeki Sahara ,  Tatsuya Fujita

    IPC分类号： A61K3170

    CPC分类号： C07H15/04 ,  A61K31/7032 ,  C07H13/00

    摘要： A method for immunosuppression in a subject comprising administering to the subject in need thereof, a pharmaceutically effective amount of at least one sulfoquinovosylacylglycerol derivative represented by General formula (1-1): wherein R101 represents an acyl residue of a higher fatty acid, and R102 represents a hydrogen atom or an acyl residue of a higher fatty acid; and a pharmaceutically acceptable salt thereof. Of the sulfoquinovosylacylglycerol derivatives, &bgr;-sulfoquinovosylacylglycerols are novel compounds. The present invention also relates to pharmaceutical composition comprising a pharmaceutically effective amount of the &bgr;-sulfoquinovosylacylglycerols and/or its pharmaceutically acceptable salt; and a pharmaceutically acceptable excipient. The pharmaceutical composition may be used as an immunosuppressive agent, anticancer agent and DNA polymerase &agr; inhibitor.

    摘要翻译： 一种受试者的免疫抑制方法，包括向有需要的受试者施用药学上有效量的通式（1-1）表示的至少一种磺基秋水仙酰基甘油衍生物：其中，R 101表示高级脂肪酸的酰基残基，R 102 表示氢原子或高级脂肪酸的酰基残基; 及其药学上可接受的盐。 在磺基奎诺糖基酰基甘油衍生物中，β-磺基奎诺乙酰基酰基甘油是新化合物。 本发明还涉及药物组合物，其包含药学上有效量的β-磺基奎诺乙酰基酰基甘油和/或其药学上可接受的盐; 和药学上可接受的赋形剂。 药物组合物可以用作免疫抑制剂，抗癌剂和DNA聚合酶α抑制剂。