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    Sulfoquinovosylacylglycerol derivative, and use thereof as medicaments
    5.
    发明授权
    Sulfoquinovosylacylglycerol derivative, and use thereof as medicaments 失效
    磺基喹诺酮酰基甘油衍生物及其作为药物的用途

    公开(公告)号：US06518410B2

    公开(公告)日：2003-02-11

    申请号：US09949907

    申请日：2001-09-10

    申请人： Takayuki Yamazaki ,  Fumio Sugawara ,  Keisuke Ohta ,  Kazuyoshi Masaki ,  Kotaro Nakayama ,  Kengo Sakaguchi ,  Noriyuki Sato ,  Hiroeki Sahara ,  Tatsuya Fujita

    发明人： Takayuki Yamazaki ,  Fumio Sugawara ,  Keisuke Ohta ,  Kazuyoshi Masaki ,  Kotaro Nakayama ,  Kengo Sakaguchi ,  Noriyuki Sato ,  Hiroeki Sahara ,  Tatsuya Fujita

    IPC分类号： A61K3170

    CPC分类号： C07H15/04 ,  A61K31/7032 ,  C07H13/00

    摘要： A method for immunosuppression in a subject comprising administering to the subject in need thereof, a pharmaceutically effective amount of at least one sulfoquinovosylacylglycerol derivative represented by General formula (1-1): wherein R101 represents an acyl residue of a higher fatty acid, and R102 represents a hydrogen atom or an acyl residue of a higher fatty acid; and a pharmaceutically acceptable salt thereof. Of the sulfoquinovosylacylglycerol derivatives, &bgr;-sulfoquinovosylacylglycerols are novel compounds. The present invention also relates to pharmaceutical composition comprising a pharmaceutically effective amount of the &bgr;-sulfoquinovosylacylglycerols and/or its pharmaceutically acceptable salt; and a pharmaceutically acceptable excipient. The pharmaceutical composition may be used as an immunosuppressive agent, anticancer agent and DNA polymerase &agr; inhibitor.

    摘要翻译： 一种受试者的免疫抑制方法，包括向有需要的受试者施用药学上有效量的通式（1-1）表示的至少一种磺基秋水仙酰基甘油衍生物：其中，R 101表示高级脂肪酸的酰基残基，R 102 表示氢原子或高级脂肪酸的酰基残基; 及其药学上可接受的盐。 在磺基奎诺糖基酰基甘油衍生物中，β-磺基奎诺乙酰基酰基甘油是新化合物。 本发明还涉及药物组合物，其包含药学上有效量的β-磺基奎诺乙酰基酰基甘油和/或其药学上可接受的盐; 和药学上可接受的赋形剂。 药物组合物可以用作免疫抑制剂，抗癌剂和DNA聚合酶α抑制剂。