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公开(公告)号：US07361744B2
公开(公告)日：2008-04-22
申请号：US11193655
申请日：2005-07-28
申请人： Takeshi Honda , Akira Okuno , Masanori Izumi , Xiaoliu Li
发明人： Takeshi Honda , Akira Okuno , Masanori Izumi , Xiaoliu Li
CPC分类号： C07H15/203 , C07H17/02
摘要： Compounds having the formula (I): wherein A represents a group such as a cyclic group, R1 and R2 represent groups such as alkyl groups or hydroxymethyl groups, and n represents 1 or 2, or pharmacologically acceptable salts thereof or pharmacologically acceptable esters thereof have superior activity and stability, and are useful for the treatment and/or prevention of diabetes mellitus, or the like.
摘要翻译： 具有式（I）的化合物：其中A表示诸如环状基团的基团，R 1和R 2表示例如烷基或羟甲基的基团，n 代表1或2，或其药学上可接受的盐或其药理学上可接受的酯具有优异的活性和稳定性，并且可用于治疗和/或预防糖尿病等。
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公开(公告)号：US20060025350A1
公开(公告)日：2006-02-02
申请号：US11193655
申请日：2005-07-28
申请人： Takeshi Honda , Akira Okuno , Masanori Izumi , Xiaoliu Li
发明人： Takeshi Honda , Akira Okuno , Masanori Izumi , Xiaoliu Li
IPC分类号： C07H15/02 , A61K31/7052
CPC分类号： C07H15/203 , C07H17/02
摘要： Compounds having the formula (I): wherein A represents a group such as a cyclic group, R1 and R2 represent groups such as alkyl groups or hydroxymethyl groups, and n represents 1 or 2, or pharmacologically acceptable salts thereof or pharmacologically acceptable esters thereof have superior activity and stability, and are useful for the treatment and/or prevention of diabetes mellitus, or the like.
摘要翻译： 具有式（I）的化合物：其中A表示诸如环状基团的基团，R 1和R 2表示例如烷基或羟甲基的基团，n 代表1或2，或其药学上可接受的盐或其药理学上可接受的酯具有优异的活性和稳定性，并且可用于治疗和/或预防糖尿病等。
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公开(公告)号：US07632930B2
公开(公告)日：2009-12-15
申请号：US12029337
申请日：2008-02-11
申请人： Takeshi Honda , Akira Okuno , Masanori Izumi , Xiaoliu Li
发明人： Takeshi Honda , Akira Okuno , Masanori Izumi , Xiaoliu Li
CPC分类号： C07H15/203 , C07H17/02
摘要： Compounds having the formula (I): wherein A represents a group such as a cyclic group, R1 and R2 represent groups such as alkyl groups or hydroxymethyl groups, and n represents 1 or 2, or pharmacologically acceptable salts thereof or pharmacologically acceptable esters thereof have superior activity and stability, and are useful for the treatment and/or prevention of diabetes mellitus, or the like.
摘要翻译： 具有式（I）的化合物：其中A表示诸如环状基团的基团，R 1和R 2表示诸如烷基或羟甲基的基团，n表示1或2，或其药学上可接受的盐或其药理学上可接受的酯具有 优异的活性和稳定性，并且可用于治疗和/或预防糖尿病等。
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公开(公告)号：US20080194495A1
公开(公告)日：2008-08-14
申请号：US12029337
申请日：2008-02-11
申请人： Takeshi Honda , Akira Okuno , Masanori Izumi , Xiaoliu Li
发明人： Takeshi Honda , Akira Okuno , Masanori Izumi , Xiaoliu Li
IPC分类号： A61K31/702 , C07H15/02 , A61P3/10
CPC分类号： C07H15/203 , C07H17/02
摘要： Compounds having the formula (I): wherein A represents a group such as a cyclic group, R1 and R2 represent groups such as alkyl groups or hydroxymethyl groups, and n represents 1 or 2, or pharmacologically acceptable salts thereof or pharmacologically acceptable esters thereof have superior activity and stability, and are useful for the treatment and/or prevention of diabetes mellitus, or the like.
摘要翻译： 具有式（I）的化合物：其中A表示诸如环状基团的基团，R 1和R 2表示例如烷基或羟甲基的基团，n 代表1或2，或其药学上可接受的盐或其药理学上可接受的酯具有优异的活性和稳定性，并且可用于治疗和/或预防糖尿病等。
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公开(公告)号：US07943584B2
公开(公告)日：2011-05-17
申请号：US11572752
申请日：2005-07-29
申请人： Masanori Izumi , Akira Okuno , Keiko Matsumura
发明人： Masanori Izumi , Akira Okuno , Keiko Matsumura
CPC分类号： A61K31/198 , A61K31/155 , A61K31/427 , A61K31/4439 , A61K31/52 , A61K31/7056 , A61K38/28 , A61K45/06 , A61K2300/00
摘要： A pharmaceutical composition effective for the prophylaxis and treatment of diabetes is provided. This pharmaceutical composition comprises the combination of an α-amylase inhibitor selected from a compound represented by the following general formula (I): [wherein A represents, for example, a cyclic group, etc. R1 and R2 represent an alkyl group, hydroxymethyl group, etc., and n represents 1 or 2], or a pharmacologically acceptable salt or ester thereof, and at least one type of drug selected from an insulin sensitizer, an insulin secretagogue, a biguanide drug, an insulin preparation and a DPP-IV inhibitor.
摘要翻译： 提供了有效预防和治疗糖尿病的药物组合物。 该药物组合物包含选自下述通式（I）表示的化合物的α-淀粉酶抑制剂的组合：[式中，A表示例如环状基团等，R 1，R 2表示烷基，羟甲基 ，等等，n表示1或2]或其药理学上可接受的盐或酯，以及至少一种选自胰岛素敏化剂，胰岛素促分泌素，双胍类药物，胰岛素制剂和DPP-IV 抑制剂。
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公开(公告)号：US20080039367A1
公开(公告)日：2008-02-14
申请号：US11572752
申请日：2005-07-29
申请人： Masanori Izumi , Akira Okuno , Keiko Matsumura
发明人： Masanori Izumi , Akira Okuno , Keiko Matsumura
IPC分类号： A61K31/7056 , A61K31/7016 , A61K38/28 , A61P3/00 , A61P3/10 , A61P9/00
CPC分类号： A61K31/198 , A61K31/155 , A61K31/427 , A61K31/4439 , A61K31/52 , A61K31/7056 , A61K38/28 , A61K45/06 , A61K2300/00
摘要： A pharmaceutical composition effective for the prophylaxis and treatment of diabetes is provided. This pharmaceutical composition comprises the combination of an α-amylase inhibitor selected from a compound represented by the following general formula (I): [wherein A represents, for example, a cyclic group, etc. R1 and R2 represent an alkyl group, hydroxymethyl group, etc., and n represents 1 or 2], or a pharmacologically acceptable salt or ester thereof, and at least one type of drug selected from an insulin sensitizer, an insulin secretagogue, a biguanide drug, an insulin preparation and a DPP-IV inhibitor.
摘要翻译： 提供了有效预防和治疗糖尿病的药物组合物。 该药物组合物包含选自下述通式（I）表示的化合物的α-淀粉酶抑制剂的组合：[式中，A表示例如环状基团等，R 1， R 2表示烷基，羟甲基等，n表示1或2]或其药理学上可接受的盐或酯，以及至少一种选自胰岛素敏化剂， 胰岛素促分泌素，双胍药，胰岛素制剂和DPP-IV抑制剂。
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公开(公告)号：US20090137499A1
公开(公告)日：2009-05-28
申请号：US12280510
申请日：2007-08-03
申请人： Takeshi Honda , Minoru Oguchi , Masao Yoshida , Ryo Okuyama , Tsuneaki Ogata , Manabu Abe , Kenjiro Ueda , Jun Ohsumi , Masanori Izumi
发明人： Takeshi Honda , Minoru Oguchi , Masao Yoshida , Ryo Okuyama , Tsuneaki Ogata , Manabu Abe , Kenjiro Ueda , Jun Ohsumi , Masanori Izumi
IPC分类号： A61K31/706 , C07G3/00 , A61K31/7004 , C07H17/02
CPC分类号： C07H15/203 , A61K9/2018 , C07H17/02
摘要： The present invention relates to a benzylphenyl glucopyranoside derivative having an excellent inhibitory effect on human SGLT1 and/or SGLT2 activity. There is provided a compound or a pharmacologically acceptable salt thereof represented by the following general formula (I): wherein R1 represents a hydrogen atom, an amino group, a hydroxy C1-C6 alkyl group, etc.; R2 represents a hydrogen atom, etc.; R3 represents a C1-C6 alkyl group, a hydroxy C1-C6 alkyl group, etc.; R4 represents a hydrogen atom, a C2-C7 acyl group, etc.; R5, R6, R7, and R8 are the same or different and each represents a hydrogen atom or a C1-C6 alkyl group, provided that R5, R6, R7 and R8 are not hydrogen atoms at the same time; n is 0 to 4; and X is CH or N.
摘要翻译： 本发明涉及对人SGLT1和/或SGLT2活性具有优异抑制作用的苄基苯基吡喃葡萄糖苷衍生物。 提供由以下通式（I）表示的化合物或其药理学上可接受的盐：其中R1表示氢原子，氨基，羟基C1-C6烷基等; R2表示氢原子等; R3表示C1-C6烷基，羟基C1-C6烷基等; R4表示氢原子，C2-C7酰基等; R5，R6，R7和R8相同或不同，各自表示氢原子或C1-C6烷基，条件是R5，R6，R7和R8不同时为氢原子; n为0〜4; X为CH或N.
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公开(公告)号：US06581817B2
公开(公告)日：2003-06-24
申请号：US10048048
申请日：2002-01-23
IPC分类号： B23K3102
CPC分类号： H01L21/67144 , H01L21/67121 , Y10T156/17
摘要： A die bonding device for installing electronic components S on a metal stem, comprising a bonding nozzle for suctioning an electronic component S and positioning the electronic component S on a component mounting face of the stem, a stem carrying head for carrying the stem, a heater section for heating the electronic component S while it is positioned on the component mounting face of the stem, and an imaging camera having a light axis L extending through the component mounting face of the stem when positioned inside the heater section, which performs reciprocating motion in the direction of the light axis L.
摘要翻译： 一种用于将电子部件S安装在金属杆上的芯片接合装置，包括用于吸引电子部件S并将电子部件S定位在杆的部件安装面上的接合喷嘴，用于承载杆的杆承载头，加热器 用于在电子部件S位于杆的部件安装面上时加热电子部件S的部分，以及成像摄像机，其具有在位于加热部内部时延伸穿过杆的部件安装面的光轴L，其进行往复运动 光轴的方向L.
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公开(公告)号：US5035308A
公开(公告)日：1991-07-30
申请号：US250603
申请日：1988-09-29
申请人： Fumiaki Baba , Masanori Izumi , Kenji Sawa , Susumu Kurumida
发明人： Fumiaki Baba , Masanori Izumi , Kenji Sawa , Susumu Kurumida
IPC分类号： F16H61/14
CPC分类号： F16H61/143 , F16H2045/0294 , F16H2061/145 , Y10T477/635
摘要： A lock-up control system for an automatic transmission including a torque converter having an input member and an output member, a multiple stage gear transmission gear mechanism connected with the output member of the torque converter and having a plurality of gear stages and a lock-up clutch for connecting the input member and the output member bypassing the torque converter wherein an engaging force in the lock-up clutch is controllable so as to change the amount of torque transmitted through the lock-up clutch. The system comprises shift detecting device for detecting a shift operation in the transmission mechanism and control device for controlling the engaging force of the torque converter to be maintained at a predetermined value smaller than a fully engaged condition of the lock-up clutch and larger than an entirely released condition of the lock-up clutch when the shift operation is detected by the shift detecting device.
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